PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAFG	1	NFE2	0	pull down	Blank V (1997)	1
CREB3	1	HCFC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFE2L2	1	MAFG	1	imaging technique, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology	Ramani K (2012), Ramani K (2012), Reinke AW (2013), Reinke AW (2013), Wang J (2011), Wu T (2013), Okita Y (2013)	7
BACH2	6	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	4
NFE2L3	6	HCFC2	1	affinity chromatography technology	Huttlin EL (2017)	1
CREB3	1	HCFC1	4	pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu R (1998), Lu R (1998), Freiman RN (1997), Freiman RN (1997), Lu R (1997), Lu R (1997), Misra V (2005), DenBoer LM (2013), Huttlin EL (2015), Huttlin EL (2017)	10
NFE2L2	1	NFE2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
GSK3B	1	NFE2L1	4	affinity chromatography technology, enzymatic study	Biswas M (2013), Biswas M (2013)	2
HCFC1	4	HCFC2	1	biochemical, affinity chromatography technology	Yokoyama A (2004), Huttlin EL (2017)	2
MAFF	0	NFE2L1	4	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Johnsen O (1996), Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	5
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
NFE2L3	6	GSK3B	1	affinity chromatography technology, enzymatic study	Kannan MB (2015), Kannan MB (2015)	2
NFE2L3	6	NFE2L1	4	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFF	0	NFE2L2	1	pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marini MG (2002), Reinke AW (2013), Okita Y (2013), Huttlin EL (2015), Huttlin EL (2017)	5
NFE2L3	6	CREB3	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFE2L3	6	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFE2L3	6	HCFC1	4	affinity chromatography technology	Huttlin EL (2017)	1
NFE2L3	6	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	4
CREB3	1	NFE2L2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
BACH2	6	MAFG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
NFE2L3	6	MAFK	0	two hybrid, affinity chromatography technology	Kobayashi A (1999), Huttlin EL (2017)	2
MAFG	1	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
HCFC1	4	NFE2L1	4	two hybrid	Ravasi T (2010)	1
NFE2L3	6	MAFG	1	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
NFE2L1	4	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
PPARG	0	NFE2L3	6	unspecified method	Lee G (2002)	1
NFE2L3	6	NFE2L2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFK	0	NFE2L2	1	pull down, two hybrid, affinity chromatography technology	Nguyen T (2000), Wang J (2011), Okita Y (2013)	3
NFE2L1	4	FBXW7	2	affinity chromatography technology, affinity chromatography technology	Biswas M (2011), Biswas M (2013)	2
GSK3B	1	NFE2L2	1	enzymatic study	Rada P (2012)	1
NFE2L3	6	FBXW7	2	affinity chromatography technology	Kannan MB (2015)	1
NFE2L3	6	NFE2	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MAFG	1	NFE2L1	4	pull down, fluorescent resonance energy transfe	Johnsen O (1996), Reinke AW (2013)	2
PPARG	0	MAFF	0	two hybrid	Ravasi T (2010)	1
NFE2L3	6	NFE2L3	6	fluorescent resonance energy transfe	Reinke AW (2013)	1