Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CD14 929 IC14 CHEMBL2109330 inhibitor TdgClinicalTrial, ChemblInteractions
CD14 929 LOVASTATIN CHEMBL503 NCI 7506029
CD14 929 FLUTICASONE PROPIONATE CHEMBL1473 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CD14 rs2569190 AA + AG Tumor necrosis factor alpha efficacy yes Cohort with inflammatory bowel disease (IBD). Subcohorts with Crohn's disease (CD) and ulcerative colitis (UC) were also analyzed. Significant results for this genotype seen for the UC cohort. Treatment efficacy was defined using the three-step scale (failure, response, or remission) and reflected the maximum response within 22 weeks after treatment initiation. Genotypes AA + AG is associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Colitis, Ulcerative as compared to genotype GG. 24776844 1296666832