PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZMYM2	5	RCOR1	0	affinity chromatography technology, pull down	Gocke CB (2008), Gocke CB (2008)	2
ARRDC1	4	OSBPL6	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VPS37A	4	TSG101	1	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid	Bache KG (2004), Bache KG (2004), Stuchell MD (2004), Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Rolland T (2014), Stefani F (2011), Albers M (2005)	9
ARRDC1	4	WWC1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	PBK	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
ADRB2	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Han SO (2012)	2
ADRB2	0	ARRDC1	4	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Patwari P (2011)	2
ARRDC1	4	YAP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITCH	1	PDCD6IP	3	affinity chromatography technology	OConnor HF (2015)	1
KCTD17	0	KCTD5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	NXN	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	TSG101	1	pull down, two hybrid, affinity chromatography technology, two hybrid	Rauch S (2011), Rauch S (2011), Nabhan JF (2012), Nabhan JF (2012)	4
ARRDC1	4	KCTD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP2	7	ABRAXAS2	1	affinity chromatography technology	Chaudhary N (2014)	1
XPO1	8	EPN1	4	affinity chromatography technology	Kirli K (2015)	1
ARRDC1	4	WWP1	3	pull down, two hybrid, affinity chromatography technology	Rauch S (2011), Rauch S (2011), Huttlin EL (2017)	3
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
KCTD17	0	KCTD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDCD6IP	3	TSG101	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid	Kim BY (2007), Ichioka F (2007), Ichioka F (2007), von Schwedler UK (2003), Schlundt A (2009), Schlundt A (2009), Schlundt A (2009), Okumura M (2009), Katoh K (2005), Strack B (2003), Strack B (2003), Zhou X (2010), Zhou X (2010), Carlton JG (2008)	14
ADRB2	0	TSG101	1	protein complementation assay	Kittanakom S (2014)	1
ARRDC1	4	ZMYM2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WDR45B	2	APP	1	pull down	Olah J (2011)	1
NEDD4L	3	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
RCOR3	0	APP	1	pull down	Olah J (2011)	1
XPO1	8	ABRAXAS2	1	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	NEDD4L	3	affinity chromatography technology	Kirli K (2015)	1
ARRDC1	4	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	ITCH	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rauch S (2011), Shea FF (2012), Puca L (2013), Huttlin EL (2015), Huttlin EL (2017)	5
TSG101	1	NEDD4	2	affinity chromatography technology	Medina G (2005)	1
KDM1A	2	RCOR3	0	affinity chromatography technology, two hybrid, biochemical	Bantscheff M (2011), Weimann M (2013), Wan C (2015)	3
XPO1	8	VPS37A	4	affinity chromatography technology	Kirli K (2015)	1
NCAPG	3	ARRDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRB1	2	NEDD4	2	affinity chromatography technology	Shenoy SK (2008)	1
ARRDC1	4	WWP2	7	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rauch S (2011), Nabhan JF (2012), Shea FF (2012), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
ADRB2	0	ITCH	1	affinity chromatography technology	Shea FF (2012)	1
XPO1	8	YAP1	0	affinity chromatography technology	Kirli K (2015)	1
KDM1A	2	XPO1	8	genetic interference	Horlbeck MA (2018)	1
TSG101	1	VPS28	2	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Stuchell MD (2004), Bishop N (2001), von Schwedler UK (2003), Martin-Serrano J (2003), Stefani F (2011), Venkatesan K (2009), Wunderley L (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
YAP1	0	ITCH	1	affinity chromatography technology	Levy D (2007)	1
PDCD6IP	3	ARRDC1	4	pull down, two hybrid, two hybrid	Rauch S (2011), Rauch S (2011), Rauch S (2011)	3
ARRB1	2	ARRDC1	4	affinity chromatography technology	Puca L (2013)	1
NEDD4	2	CUEDC1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
ARRDC1	4	ANKRD13A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	RCOR1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	KDM1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	GLMN	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	HECW2	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	WDR45B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	OSBPL3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	APP	1	pull down	Olah J (2011)	1
XPO1	8	VPS28	2	affinity chromatography technology	Kirli K (2015)	1
ARRDC1	4	KCTD5	0	affinity chromatography technology	Huttlin EL (2015)	1
ARRDC1	4	VPS37A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
ARRDC1	4	NEDD4	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rauch S (2011), Huttlin EL (2015), Huttlin EL (2017)	3
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
ARRDC1	4	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	KCTD17	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	ARRDC1	4	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	KCTD5	0	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	ANKRD13A	1	affinity chromatography technology	Kirli K (2015)	1
NEDD4	2	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology	Sette P (2010), Sette P (2010)	2
ARRB1	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Bhandari D (2007)	2
ARRDC1	4	EPN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KDM1A	2	ZMYM2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Gocke CB (2008), Shi YJ (2005), Lee MG (2005)	4
TSG101	1	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
VPS37A	4	VPS28	2	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bache KG (2004), Bache KG (2004), Bache KG (2004), Bache KG (2004), Stefani F (2011), Huttlin EL (2015), Huttlin EL (2017)	7
XPO1	8	WWC1	5	affinity chromatography technology	Kirli K (2015)	1
ARRDC1	4	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP2	7	PDCD6IP	3	affinity chromatography technology	Dores MR (2015)	1
VPS37A	4	KDM1A	2	two hybrid	Weimann M (2013)	1
VPS37A	4	APP	1	pull down	Olah J (2011)	1