PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DVL2	5	TRAF2	1	two hybrid	Rual JF (2005)	1
TNFAIP8	0	TIFA	4	two hybrid	Rolland T (2014)	1
SDCBP	0	TNFAIP8	0	two hybrid	Rolland T (2014)	1
TIFA	4	TRAF6	0	affinity chromatography technology	Takatsuna H (2003)	1
GPR156	2	TIFA	4	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	LNX1	7	two hybrid	Rual JF (2005)	1
TIFA	4	ZCCHC11	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Minoda Y (2006), Minoda Y (2006), Minoda Y (2006)	3
TXN2	0	TIFA	4	two hybrid	Rolland T (2014)	1
SDCBP	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen F (2008), Chen F (2008)	2
ELAVL1	0	DVL2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
TIFA	4	TIFA	4	affinity chromatography technology, biochemical	Takatsuna H (2003), Takatsuna H (2003)	2
TRAF2	1	TIFA	4	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
SDCBP2	2	TIFA	4	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
ELAVL1	0	HIRA	5	affinity chromatography technology	Abdelmohsen K (2009)	1
NIF3L1	0	TIFA	4	two hybrid	Rual JF (2005)	1
ELAVL1	0	SDCBP	0	two hybrid	Rolland T (2014)	1
ARHGEF39	0	TIFA	4	two hybrid	Rolland T (2014)	1
LNX1	7	TIFA	4	two hybrid	Rual JF (2005)	1
NXF1	0	TIFA	4	two hybrid	Rolland T (2014)	1
TRAF2	1	NUDT18	0	two hybrid	Rual JF (2005)	1
DVL2	5	ARHGEF39	0	two hybrid	Rual JF (2005)	1
TIFA	4	IRAK1	1	affinity chromatography technology	Takatsuna H (2003)	1
TRAF2	1	NIF3L1	0	two hybrid	Rual JF (2005)	1
RPL9	1	TXN2	0	biochemical	Havugimana PC (2012)	1
NXF1	0	HIRA	5	affinity chromatography technology	Castello A (2012)	1
NXF1	0	IRAK1	1	affinity chromatography technology	Castello A (2012)	1
ELAVL1	0	ZCCHC11	1	affinity chromatography technology	Abdelmohsen K (2009)	1
NUDT18	0	TIFA	4	two hybrid	Rual JF (2005)	1
AP1M1	3	TIFA	4	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SDCBP	0	TIFA	4	two hybrid	Rolland T (2014)	1
DVL2	5	TIFA	4	two hybrid	Rual JF (2005)	1
RPL9	1	TIFA	4	two hybrid	Rolland T (2014)	1
ELAVL1	0	TIFA	4	affinity chromatography technology	Abdelmohsen K (2009)	1
DVL2	5	AP1M1	3	two hybrid	Rual JF (2005)	1
HIRA	5	TIFA	4	affinity chromatography technology	Lee JS (2016)	1