PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HLA-G	0	HLA-B	0	affinity chromatography technology	Huttlin EL (2017)	1
PTPRC	1	CD8A	0	fluorescent resonance energy transfe	Mittler RS (1991)	1
HLA-B	0	CD8A	0	pull down	Gao GF (2000)	1
HLA-B	0	HLA-C	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HLA-G	0	CD8A	0	pull down, pull down	Gao GF (2000), Sanders SK (1991)	2
CD8A	0	CD8A	0	imaging technique, x-ray crystallography	Sun J (1997), Giblin PA (1994)	2
HLA-C	1	CD8A	0	pull down	Gao GF (2000)	1
HLA-C	1	HLA-A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LNX1	7	LNX2	2	two hybrid	Guo Z (2012)	1
CD8A	0	CD8B	0	imaging technique	Sun J (1997)	1
HLA-A	0	CD8A	0	x-ray crystallography, pull down	Gao GF (1997), Gao GF (2000)	2
HLA-C	1	HLA-G	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CACYBP	0	CD8A	0	two hybrid	Wang J (2011)	1
CD8A	0	LNX2	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Dagostino M (2011), Dagostino M (2011), Dagostino M (2011), Dagostino M (2011), Dagostino M (2011)	5
CD3D	0	CD8A	0	fluorescent resonance energy transfe, affinity chromatography technology	Doucey MA (2003), Doucey MA (2003)	2
CD8A	0	LNX1	7	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Dagostino M (2011), Dagostino M (2011), Dagostino M (2011), Dagostino M (2011)	4
CD8A	0	CDK1	0	two hybrid	Wang J (2011)	1
HLA-B	0	HLA-A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HLA-G	0	HLA-A	0	affinity chromatography technology	Huttlin EL (2017)	1
CD8A	0	COPA	6	affinity chromatography technology	Watkin LB (2015)	1
CD8A	0	CD59	2	pull down	Ninomiya H (1992)	1
LNX1	7	COPA	6	affinity chromatography technology	Lenihan JA (2017)	1