PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHMP4C	1	TRPC4AP	4	two hybrid	Tsang HT (2006)	1
XPO1	8	CHMP4C	1	affinity chromatography technology	Kirli K (2015)	1
USP54	5	CHMP1B	0	pull down	Rigden DJ (2009)	1
CHMP4C	1	128872	0	two hybrid	Rolland T (2014)	1
CCDC12	0	CHMP4C	1	biochemical	Wan C (2015)	1
USP54	5	CHMP4C	1	pull down	Rigden DJ (2009)	1
PDCD6IP	3	CHMP4B	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007), von Schwedler UK (2003), Zhou X (2010), Sette P (2013), Hein MY (2015), Dores MR (2015)	7
STAMBP	2	CHMP1B	0	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, two hybrid	Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Wang J (2011), Rolland T (2014)	10
CHMP4C	1	CC2D1A	1	two hybrid	Tsang HT (2006)	1
XPO1	8	CC2D1A	1	affinity chromatography technology	Kirli K (2015)	1
VPS4A	4	CHMP1B	0	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006), Tsang HT (2006)	3
PDCD6IP	3	CHMP4A	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rauch S (2011), von Schwedler UK (2003), Strack B (2003), Strack B (2003), Carlton JG (2008)	5
CHMP4A	1	VPS4A	4	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Strack B (2003), Tsang HT (2006)	3
CHMP4C	1	PDCD6IP	3	two hybrid, two hybrid	von Schwedler UK (2003), Wang J (2011)	2
CHMP4C	1	CHMP1B	0	biochemical	Wan C (2015)	1
USP8	7	CHMP1B	0	two hybrid, pull down, affinity chromatography technology, pull down	Row PE (2007), Row PE (2007), Row PE (2007), Rigden DJ (2009)	4
STAMBP	2	CHMP4A	1	two hybrid, two hybrid	Row PE (2007), Tsang HT (2006)	2
CHMP4C	1	CHMP4C	1	two hybrid	von Schwedler UK (2003)	1
CHMP4B	2	CHMP4A	1	two hybrid	Tsang HT (2006)	1
STAMBP	2	CHMP4B	2	two hybrid, two hybrid, two hybrid	Row PE (2007), Tsang HT (2006), Tsang HT (2006)	3
USP8	7	CHMP4C	1	pull down, pull down	Row PE (2007), Rigden DJ (2009)	2
CHMP4C	1	CHMP4A	1	two hybrid	von Schwedler UK (2003)	1
CHMP4A	1	CC2D1A	1	two hybrid	Tsang HT (2006)	1
CHMP4C	1	CHMP4B	2	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
CHMP4B	2	CC2D1A	1	affinity chromatography technology	Hein MY (2015)	1
VPS4A	4	CHMP4B	2	two hybrid, two hybrid	Tsang HT (2006), Tsang HT (2006)	2
STAMBP	2	CHMP4C	1	pull down	Row PE (2007)	1
CHMP4B	2	CHMP1B	0	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
CHMP4C	1	VPS4A	4	two hybrid	von Schwedler UK (2003)	1