PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PAXIP1	1	PIAS2	2	two hybrid	Woods NT (2012)	1
PIAS2	2	GTF2IRD1	6	pull down, two hybrid	Tussie-Luna MI (2002), Carmona-Mora P (2015)	2
JUN	0	SMAD4	9	affinity chromatography technology	Li X (2015)	1
AR	3	SIAH2	0	affinity chromatography technology, affinity chromatography technology	Qi J (2013), Tan G (2017)	2
PIAS2	2	RUFY1	4	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
PIAS2	2	ZBTB8A	0	two hybrid	Rolland T (2014)	1
NR3C1	2	PML	7	two hybrid	Ravasi T (2010)	1
UBE2I	0	TRIM63	0	two hybrid	McElhinny AS (2002)	1
NR3C1	2	JUN	0	pull down	Lerner L (2003)	1
TRIM27	2	CCHCR1	2	two hybrid	Rolland T (2014)	1
PAXIP1	1	ZBTB8A	0	two hybrid	Rual JF (2005)	1
TP53	0	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan J (2008), Fan J (2008), Kim SJ (2012)	3
PIAS2	2	NAV2	10	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PIAS4	5	SMAD3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003)	6
FLI1	2	SIAH1	2	two hybrid	Rolland T (2014)	1
AKT1	1	AR	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2001), Lin HK (2001), Deep G (2008), Deep G (2008), Steely AM (2017)	5
PIAS2	2	ESR1	0	pull down	Kotaja N (2000)	1
PARK7	0	SREBF2	5	affinity chromatography technology	Yamaguchi S (2012)	1
MBD1	1	PIAS2	2	two hybrid, pull down	Lyst MJ (2006), Lyst MJ (2006)	2
MBD1	1	MYC	2	affinity chromatography technology	Zhang B (2016)	1
TRIM63	0	SUMO2	0	two hybrid, pull down	Dai KS (2001), Dai KS (2001)	2
CTBP1	2	PIAS2	2	two hybrid	Corominas R (2014)	1
ARNT	1	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIAS2	2	HIC1	1	enzymatic study, imaging technique	Stankovic-Valentin N (2007), Sun L (2013)	2
MAPK8	3	TRAF2	1	affinity chromatography technology	Gravestein LA (1998)	1
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
PIAS2	2	CCNDBP1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZBTB8A	0	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology	Kim MK (2013), Kim MK (2013), Kim MK (2013)	3
LMNA	2	SIAH1	2	two hybrid	Dittmer TA (2014)	1
MYC	2	ARNT	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SIAH2	0	PIAS1	4	two hybrid, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Depaux A (2007), Depaux A (2007), Depaux A (2007), Depaux A (2007), Lee JH (2016)	5
TRIM63	0	PIAS2	2	two hybrid	Witt CC (2008)	1
AKT1	1	PIAS1	4	two hybrid	Depaux A (2007)	1
ESR1	0	PIAS1	4	two hybrid	Kobayashi S (2004)	1
FLI1	2	SMAD3	1	two hybrid	Ravasi T (2010)	1
JUN	0	MYC	2	affinity chromatography technology	Levy S (2010)	1
MBD1	1	PIAS1	4	affinity chromatography technology, two hybrid, pull down	McGough JM (2008), Lyst MJ (2006), Lyst MJ (2006)	3
UBE2I	0	PLAGL1	0	pull down, two hybrid	Chang YL (2007), Chang YL (2007)	2
SUMO1	0	391257	0	two hybrid	Rolland T (2014)	1
C1QA	0	PIAS2	2	two hybrid	Wang J (2011)	1
SUMO3	0	PIAS1	4	pull down	Hecker CM (2006)	1
CCNDBP1	0	JUN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	TRIM55	2	two hybrid, affinity chromatography technology	McElhinny AS (2002), Lange S (2005)	2
PIAS1	4	JUN	0	pull down, enzymatic study	Schmidt D (2002), Schmidt D (2002)	2
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
UBE2I	0	ZBED1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PIAS1	4	FLI1	2	enzymatic study	van den Akker E (2005)	1
CTBP1	2	UBE2I	0	affinity chromatography technology	Kuppuswamy M (2008)	1
TRIM27	2	PIAS2	2	affinity chromatography technology, two hybrid	Matsuura T (2005), Matsuura T (2005)	2
ZNF451	3	PIAS2	2	two hybrid	Karvonen U (2008)	1
MX2	5	PIAS2	2	two hybrid	Rolland T (2014)	1
GLUL	2	PIAS2	2	two hybrid	Bandyopadhyay S (2010)	1
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
UBE2I	0	CHMP4B	2	two hybrid, two hybrid	Rual JF (2005), Tsang HT (2006)	2
PAXIP1	1	CCNDBP1	0	two hybrid	Woods NT (2012)	1
SUMO1	0	PIAS2	2	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid	Lee BH (2003), Stehmeier P (2009), Wang J (2011), Hecker CM (2006), Hecker CM (2006), Rolland T (2014)	6
TRIM27	2	PIAS4	5	affinity chromatography technology, two hybrid	Matsuura T (2005), Matsuura T (2005)	2
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
SUMO2	0	PIAS4	5	pull down, two hybrid, two hybrid, pull down, pull down	Goehler H (2004), Goehler H (2004), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
CHMP4B	2	PIAS2	2	two hybrid	Tsang HT (2006)	1
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
PARK7	0	PIAS2	2	two hybrid, pull down, affinity chromatography technology	Takahashi K (2001), Takahashi K (2001), Takahashi K (2001)	3
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
ADA	0	PIAS2	2	two hybrid	Wang J (2011)	1
CDCA8	0	UBE2I	0	two hybrid, enzymatic study	Klein UR (2009), Klein UR (2009)	2
TRIM27	2	PIAS1	4	two hybrid, affinity chromatography technology	Matsuura T (2005), Matsuura T (2005)	2
UBE2I	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rizos H (2005), Wang S (2015), Ivanschitz L (2015), Ivanschitz L (2015), Ivanschitz L (2015)	5
TP53	0	GTF2I	1	affinity chromatography technology	Horikawa I (2014)	1
ESR1	0	MAPKAPK2	1	affinity chromatography technology	Tarallo R (2011)	1
PIAS2	2	SMAD4	9	pull down	Li X (2006)	1
SMAD4	9	AKT1	1	affinity chromatography technology	Song K (2006)	1
PIAS2	2	NR3C1	2	pull down	Kotaja N (2000)	1
PML	7	ARNT	1	pull down	Tojo M (2002)	1
SMAD3	1	NR3C1	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li G (2003), Li G (2003), Song CZ (1999), Song CZ (1999)	4
SIAH1	2	PIAS1	4	two hybrid, pull down, affinity chromatography technology	Depaux A (2007), Depaux A (2007), Lee JH (2016)	3
PIAS2	2	JUN	0	pull down, enzymatic study	Schmidt D (2002), Schmidt D (2002)	2
UBE2I	0	GTF2I	1	enzymatic study	Gocke CB (2005)	1
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
UBE2I	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
SIAH2	0	PIAS2	2	two hybrid	Depaux A (2007)	1
SMAD3	1	JUN	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Verrecchia F (2000), Liberati NT (1999), Liberati NT (2001), Lee SY (2011)	7
CDKN2A	1	PIAS2	2	affinity chromatography technology, affinity chromatography technology	Herkert B (2010), Herkert B (2010)	2
IFIH1	2	PIAS2	2	affinity chromatography technology, affinity chromatography technology	Fu J (2011), Fu J (2011)	2
MAPK8	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Ishitani T (2003), Nishitoh H (1998), Derijard B (1994), Derijard B (1994), Yazgan O (2002), Tada K (2001), Meyer CF (1996), Cano E (1995), Cano E (1995), Trivedi AK (2007), Zhu F (2006), Zuniga A (1999), Zuniga A (1999), Higashimoto T (2008), Garcia-Guzman M (2000), Singhirunnusorn P (2005), Hofmann TG (2005), Lewis J (2004), Jeon YJ (2009), Yamashita M (2008), Ryoo K (2004), Abell AN (2005), Burns K (1998), Hirano T (2002), Gravestein LA (1998), Dadgostar H (2003), Han YH (2006), Kolluri SK (2003), Chen LY (2003), Manna SK (2010), Gallagher ED (2002), Liu HP (2011), Xia Y (1998), Funakoshi-Tago M (2005), Ho DT (2006), Wang J (2000), Choi HK (2011), Chang TS (2003), Yao K (2009), Chang TS (2003), Dai R (2000), Gupta S (1996), Gupta S (1996), Sundarrajan M (2003), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Lee KH (2005), Kadoya T (2005), Katagiri C (2006), Yao K (2007), Wu X (2007), Kato T (2008), Cavigelli M (1995), Katagiri C (2006), Choi BY (2005), Choi BY (2005), Yuan ZQ (2003), Phelan DR (2001), Eliopoulos AG (2006), Hayashi T (2007), Zhang J (2013), Li X (2002), Kendrick TS (2004), Holzberg D (2003), Grau R (2004), Hernandez M (2000), Hwang SG (2014), Larsson H (1999), Rausch O (1997), Morley SJ (2000), Ho JM (2002), Shkoda A (2012), Pop M (2004), Chang HY (1999)	76
PIAS1	4	PML	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	3
PIAS2	2	PGR	1	pull down	Kotaja N (2000)	1
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
LMNB1	1	PIAS2	2	two hybrid	Yu H (2011)	1
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
TP53	0	PIAS2	2	pull down, pull down, two hybrid, enzymatic study, enzymatic study, imaging technique	Schmidt D (2002), Schmidt D (2002), Wang J (2008), Wu SY (2009), Schmidt D (2002), Chen TC (2014)	6
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
TRAF2	1	SIAH2	0	pull down	Habelhah H (2002)	1
TRAF2	1	391257	0	two hybrid	Rolland T (2014)	1
ZNF451	3	PML	7	enzymatic study	Koidl S (2016)	1
GTF2I	1	PIAS2	2	two hybrid	Corominas R (2014)	1
SUMO2	0	PIAS1	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Gocke CB (2008), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ullmann R (2012), Ouyang J (2009)	9
MYC	2	UBE2I	0	genetic interference	Toyoshima M (2012)	1
NR3C1	2	MSX2	1	two hybrid	Ravasi T (2010)	1
SMAD4	9	UBE2I	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Chang CC (2005), Lin X (2003), Colland F (2004), Wang J (2011), Wang J (2011)	6
UBE2I	0	NR3C1	2	enzymatic study	Ogawa H (2009)	1
PIAS2	2	ARNT	1	affinity chromatography technology	Aesoy R (2014)	1
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
CLDN2	0	PIAS2	2	two hybrid	Van Itallie CM (2012)	1
PHC1	1	391257	0	two hybrid	Rolland T (2014)	1
TP53	0	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Rolfo A (2012), Rolfo A (2012)	6
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
CLDN2	0	UBE2I	0	two hybrid	Van Itallie CM (2012)	1
AKT1	1	PIAS2	2	two hybrid, imaging technique	Depaux A (2007), Chen TC (2014)	2
SREBF2	5	UBE2I	0	affinity chromatography technology, two hybrid	Hirano Y (2003), Bandyopadhyay S (2010)	2
TRIM55	2	PIAS2	2	two hybrid	Witt CC (2008)	1
TP53	0	CTBP1	2	affinity chromatography technology, affinity chromatography technology	Jin W (2008), Jin W (2008)	2
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
DNMT3A	17	MYC	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brenner C (2005), Brenner C (2005), Brenner C (2005), Brenner C (2005), Hervouet E (2009)	5
MAPK8	3	PIAS2	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Liu J (2009), Liu J (2009), Liu J (2009), Liu J (2009)	4
TRAF2	1	CCHCR1	2	two hybrid	Rolland T (2014)	1
LMNA	2	LMNB1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, bioid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ostlund C (2001), Liu GH (2011), Ju WN (2009), Roux KJ (2012), Wang J (2011), Dittmer TA (2014), Depreux FF (2015), Dou Z (2015)	8
TRIM55	2	TRIM27	2	two hybrid	Woodsmith J (2012)	1
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
PML	7	PLAGL1	0	pull down	Ho CL (2010)	1
CDKN2A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PML	7	SIAH2	0	affinity chromatography technology, affinity chromatography technology, pull down	Fanelli M (2004), Fanelli M (2004), Fanelli M (2004)	3
TP53	0	LMNA	2	affinity chromatography technology	Horikawa I (2014)	1
AR	3	PIAS1	4	two hybrid, affinity chromatography technology	Kotaja N (2000), Toropainen S (2015)	2
PIAS2	2	PIAS2	2	two hybrid, enzymatic study	Rolland T (2014), Schmidt D (2002)	2
MITF	3	PIAS2	2	pull down, pull down	Murakami H (2005), Murakami H (2005)	2
PIAS4	5	HIC1	1	imaging technique	Sun L (2013)	1
TRIM23	3	SIAH1	2	two hybrid	Rolland T (2014)	1
PARK7	0	AR	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Tillman JE (2007), Tillman JE (2007), Tillman JE (2007)	3
PHC1	1	SIAH1	2	two hybrid	Rolland T (2014)	1
AKT1	1	GFAP	0	two hybrid	Arroyo R (2015)	1
MAPK8	3	AKT1	1	enzymatic study	Xiao L (2010)	1
SUMO2	0	ZBED1	0	pull down	Ouyang J (2009)	1
PHC1	1	UBE2I	0	two hybrid	Rual JF (2005)	1
NR3C1	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sengupta S (2000), Sengupta S (2001), Sengupta S (2001), Sengupta S (2001)	4
ZNF451	3	PIAS1	4	two hybrid, imaging technique	Karvonen U (2008), Karvonen U (2008)	2
PIAS1	4	PLAG1	2	pull down	Van Dyck F (2004)	1
UBE2I	0	391257	0	two hybrid	Rolland T (2014)	1
MAPKAPK2	1	PIAS2	2	enzymatic study	Heo KS (2013)	1
SUMO3	0	PIAS2	2	pull down, unspecified method	Hecker CM (2006), Banani SF (2016)	2
FLI1	2	UBE2I	0	two hybrid	van den Akker E (2005)	1
GOLGA2	2	UBE2I	0	two hybrid	Rolland T (2014)	1
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
NR3C1	2	SUMO1	0	affinity chromatography technology	Lin DY (2006)	1
PIAS1	4	HIC1	1	enzymatic study	Stankovic-Valentin N (2007)	1
PML	7	SIAH1	2	affinity chromatography technology	Kraemer OH (2008)	1
TRIM63	0	PIAS1	4	two hybrid	Witt CC (2008)	1
CDKN2B	0	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LMNA	2	PML	7	bioid	Roux KJ (2012)	1
PIAS2	2	TSR2	1	two hybrid	Rolland T (2014)	1
PIAS2	2	PLAGL1	0	pull down	Van Dyck F (2004)	1
SREBF2	5	PIAS1	4	two hybrid	Bandyopadhyay S (2010)	1
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
HUWE1	22	MYC	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Adhikary S (2005), Koch HB (2007), Fan L (2015), Zhao X (2008)	6
GFAP	0	PIAS2	2	two hybrid	Rolland T (2014)	1
ZNF451	3	AR	3	affinity chromatography technology, two hybrid	Karvonen U (2008), Karvonen U (2008)	2
JUN	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teyssier C (2001), Baron S (2007), Ruiz ML (2013), Ruiz ML (2013)	4
SMAD3	1	PLAGL1	0	two hybrid	Colland F (2004)	1
UBE2I	0	TRIM23	3	two hybrid, two hybrid, two hybrid	Markson G (2009), Rolland T (2014), Yu H (2011)	3
GTF2I	1	MYC	2	pull down, affinity chromatography technology, affinity chromatography technology	Roy AL (1993), Roy AL (1993), Koch HB (2007)	3
PIAS2	2	391257	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CDKN2A	1	MAPK8	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Choi BY (2005), Choi BY (2005), Choi BY (2005), Choi BY (2005)	4
PIAS2	2	PIAS4	5	two hybrid	Wang J (2011)	1
JUN	0	ARNT	1	affinity chromatography technology, affinity chromatography technology	Chang KY (2009), Chang KY (2009)	2
CDKN2A	1	PML	7	affinity chromatography technology, affinity chromatography technology, imaging technique	Ivanschitz L (2015), Ivanschitz L (2015), Ivanschitz L (2015)	3
PIAS2	2	PLAG1	2	pull down	Van Dyck F (2004)	1
ESR1	0	UBE2I	0	two hybrid, enzymatic study	Kobayashi S (2004), Sentis S (2005)	2
ESR1	0	GOLGA2	2	affinity chromatography technology	Tarallo R (2011)	1
DNMT3A	17	PIAS1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004), Liu B (2010), Liu B (2010)	6
MYC	2	PIAS2	2	affinity chromatography technology	Zhang Y (2007)	1
PIAS2	2	ESR2	1	pull down	Kotaja N (2000)	1
SUMO1	0	MITF	3	affinity chromatography technology	Murakami H (2005)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
GTF2IRD1	6	PIAS1	4	two hybrid	Carmona-Mora P (2015)	1
SREBF2	5	PIAS2	2	two hybrid	Bandyopadhyay S (2010)	1
CDKN2A	1	CCNDBP1	0	two hybrid	Daakour S (2016)	1
PAXIP1	1	PIAS1	4	two hybrid	Woods NT (2012)	1
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
TRIM27	2	PML	7	affinity chromatography technology	Cao T (1998)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
TP53	0	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SUMO2	0	ZNF451	3	pull down	Ouyang J (2009)	1
TP53	0	ARNT	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SUMO2	0	PIAS2	2	two hybrid, two hybrid, pull down, pull down, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
PML	7	PARK7	0	affinity chromatography technology	Kim SJ (2012)	1
SUMO3	0	PML	7	imaging technique	Cuchet-Lourenco D (2011)	1
JUN	0	SUMO1	0	protein complementation assay	Fang D (2004)	1
PRKAB2	0	PIAS2	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
SUMO1	0	ZNF451	3	pull down	Karvonen U (2008)	1
PARK7	0	UBE2I	0	two hybrid	Junn E (2005)	1
ADA	0	NR3C1	2	pull down	Henriksson A (1997)	1
MYC	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
MITF	3	PIAS1	4	pull down	Murakami H (2005)	1
ARNT	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDCA8	0	PIAS2	2	two hybrid	Klein UR (2009)	1
HUWE1	22	PIAS2	2	enzymatic study, affinity chromatography technology	Yang Y (2010), Yang Y (2010)	2
CTBP1	2	AKT1	1	affinity chromatography technology	Merrill JC (2010)	1
PGR	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Giulianelli S (2012), Giulianelli S (2012), Giulianelli S (2012)	3
MYC	2	PML	7	affinity chromatography technology, affinity chromatography technology, pull down	Cairo S (2005), Buschbeck M (2007), Buschbeck M (2007)	3
PIAS4	5	UBE2I	0	two hybrid, pull down, pull down, pull down	Wang J (2011), Yamamoto H (2003), Yin Y (2012), Ryu H (2010)	4
DNMT3A	17	HIC1	1	affinity chromatography technology, affinity chromatography technology	Zeng S (2016), Zeng S (2016)	2
PIAS2	2	CDKN2B	0	imaging technique	Chen TC (2014)	1
GLUL	2	PIAS1	4	two hybrid	Bandyopadhyay S (2010)	1
SMAD4	9	SUMO1	0	affinity chromatography technology	Lee PS (2003)	1
MAPK8	3	MYC	2	enzymatic study, pull down, affinity chromatography technology	Noguchi K (1999), Noguchi K (1999), Noguchi K (1999)	3
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
JUN	0	STAT4	3	affinity chromatography technology	Nakahira M (2002)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
PIAS2	2	ACY3	1	two hybrid	Rolland T (2014)	1
JUN	0	UBE2I	0	two hybrid, enzymatic study	Goettlicher M (1996), Muller S (2000)	2
PHC1	1	PIAS2	2	two hybrid	Rolland T (2014)	1
PARK7	0	SUMO1	0	two hybrid	Junn E (2005)	1
UBE2I	0	ZNF451	3	two hybrid, two hybrid, enzymatic study, two hybrid, two hybrid	Rual JF (2005), Bandyopadhyay S (2010), Karvonen U (2008), Karvonen U (2008), Yu H (2011)	5
MYC	2	SMAD3	1	affinity chromatography technology, pull down, two hybrid	Feng XH (2002), Feng XH (2002), Feng XH (2002)	3
PLAGL1	0	TP53	0	pull down, genetic interference	Huang SM (2001), Huang SM (2001)	2
TRIM23	3	391257	0	two hybrid	Rolland T (2014)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
TRIM27	2	TP53	0	affinity chromatography technology, pull down, enzymatic study	Chu Y (2011), Chu Y (2011), Chu Y (2011)	3
SMAD3	1	SREBF2	5	affinity chromatography technology, affinity chromatography technology	Grimsby S (2004), Grimsby S (2004)	2
TRIM23	3	PIAS2	2	two hybrid	Rolland T (2014)	1
MAPK8	3	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Hu MC (1997), Yin ZM (2004), Yin ZM (2004), Fuchs SY (1998), Topisirovic I (2009), Drago-Ferrante R (2008), Wang J (2000), Chang NS (2003), Fuchs SY (1998)	9
MYC	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	MAPKAPK2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, imaging technique	Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Wu R (2007), Wu R (2007), Chen TC (2014)	7
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
GOLGA2	2	PIAS2	2	two hybrid	Rolland T (2014)	1
TRAF2	1	JUN	0	enzymatic study	Park KJ (2003)	1
PML	7	JUN	0	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vallian S (1998), Yasuda S (1999), Salomoni P (2005), Salomoni P (2005), Seo SR (2006), Seo SR (2006), Seo SR (2006)	7
HIC1	1	CTBP1	2	two hybrid, affinity chromatography technology	Van Rechem C (2009), Stankovic-Valentin N (2006)	2
DNMT3A	17	PIAS2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004)	4
SIAH1	2	PIAS2	2	two hybrid	Depaux A (2007)	1
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
SMAD4	9	PIAS1	4	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
PIAS2	2	STAT4	3	affinity chromatography technology	Arora T (2003)	1
TP53	0	CHMP4B	2	affinity chromatography technology	Horikawa I (2014)	1
ARNT	1	ESR1	0	pull down	Beischlag TV (2005)	1
AR	3	PIAS4	5	pull down, pull down	Gross M (2001), Gross M (2004)	2
PIAS4	5	PLAG1	2	pull down	Van Dyck F (2004)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIAS2	2	PML	7	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Cuchet-Lourenco D (2011), Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	4
TP53	0	PIAS1	4	two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, imaging technique, pull down	Gallagher WM (1999), Kahyo T (2001), Kahyo T (2001), Schmidt D (2002), Pelisch F (2010), Schmidt D (2002), Chen TC (2014), Okubo S (2004)	8
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
AR	3	PIAS2	2	two hybrid, two hybrid, pull down, pull down	Kotaja N (2000), Moilanen AM (1999), Moilanen AM (1999), Kotaja N (2000)	4
AKT1	1	ARNT	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe	Li YM (2005), Li YM (2005), Li YM (2005), Ivanov AA (2017)	4
MYC	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PRKAB2	0	TRAF2	1	two hybrid, two hybrid, two hybrid	Corominas R (2014), Rolland T (2014), Yu H (2011)	3
PIAS2	2	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology	Liu J (2011), Liu J (2011), Liu J (2011)	3
UBE2I	0	TRIM27	2	two hybrid, affinity chromatography technology	Markson G (2009), Chu Y (2011)	2
LMNA	2	PIAS2	2	two hybrid	Dittmer TA (2014)	1
MSX2	1	PIAS2	2	two hybrid, pull down	Wu L (1997), Wu L (1997)	2
JUN	0	AR	3	affinity chromatography technology, affinity chromatography technology	Sato N (1997), Sato N (1997)	2
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
GFAP	0	TRIM27	2	two hybrid	Rolland T (2014)	1
PIAS2	2	SMAD3	1	pull down	Li X (2006)	1
UBE2I	0	HIC1	1	enzymatic study, affinity chromatography technology	Stankovic-Valentin N (2007), Dehennaut V (2013)	2
MITF	3	UBE2I	0	two hybrid, pull down, pull down	Xu W (2000), Xu W (2000), Murakami H (2005)	3
PIAS2	2	ZBED1	0	two hybrid	Rolland T (2014)	1
SUMO1	0	PIAS4	5	two hybrid	Hecker CM (2006)	1
TRIM55	2	PIAS1	4	two hybrid	Witt CC (2008)	1
SIAH2	0	UBE2I	0	two hybrid, two hybrid, two hybrid	Depaux A (2007), Hu G (1997), Wang J (2011)	3
GLUL	2	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
UBE2I	0	LMNA	2	two hybrid, affinity chromatography technology, enzymatic study	Zhong N (2005), Zhong N (2005), Matafora V (2009)	3
GOLGA2	2	CCHCR1	2	two hybrid	Rolland T (2014)	1
PRKAB2	0	GOLGA2	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
MAPK8	3	SMAD3	1	imaging technique	Chen TC (2014)	1
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
CDKN2B	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
DNMT3A	17	UBE2I	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Ling Y (2004), Ling Y (2004), Ling Y (2004), Ling Y (2004)	4
FLI1	2	PIAS2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	van den Akker E (2005), van den Akker E (2005), van den Akker E (2005), van den Akker E (2005), van den Akker E (2005)	5
PLAGL1	0	SUMO1	0	enzymatic study	Liu ST (2012)	1
PHC1	1	SUMO1	0	two hybrid	Rolland T (2014)	1
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
PIAS2	2	CCHCR1	2	two hybrid	Rolland T (2014)	1
SMAD3	1	PLAG1	2	two hybrid	Colland F (2004)	1
GFAP	0	GOLGA2	2	two hybrid	Rolland T (2014)	1
PIAS2	2	TICAM2	0	two hybrid	Wang J (2011)	1