PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
H2AFX	1	HIST2H2BE	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Du YC (2006), Lee HS (2010)	3
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
TRIM25	5	CHD4	22	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
HIST2H2AC	1	HIST2H2BE	1	pull down	Long L (2014)	1
MDC1	8	RAD50	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Xu X (2003), Goldberg M (2003), Goldberg M (2003), Stewart GS (2003), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008)	7
CHEK2	2	FOXM1	3	enzymatic study	Tan Y (2007)	1
SUMO2	0	TP53BP1	3	pull down	Ouyang J (2009)	1
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
TP53BP1	3	H2AFX	1	affinity chromatography technology, imaging technique, imaging technique, unspecified method, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Sengupta S (2004), Sengupta S (2004), Fernandez-Capetillo O (2002), Ward IM (2003), Walters DK (2011), Stewart GS (2003), Fraser M (2011), Rassoolzadeh H (2015)	8
HERC2	9	UBE2D1	0	pull down	Bai B (2016)	1
UBE2D1	0	NBN	1	pull down	Lu CS (2012)	1
XRCC5	5	BARD1	4	affinity chromatography technology, affinity chromatography technology	Wei L (2008), Woods NT (2012)	2
WRAP53	1	RNF8	2	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Henriksson S (2014), Henriksson S (2014), Rassoolzadeh H (2015), Rassoolzadeh H (2015)	4
BARD1	4	UBE2W	0	pull down, pull down	David Y (2011), Vittal V (2015)	2
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
BARD1	4	H2AFX	1	pull down	Mallery DL (2002)	1
RNF8	2	POLD4	0	enzymatic study	Zhang S (2013)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
RAD50	3	RNF8	2	affinity chromatography technology	Lu CS (2012)	1
MAGED1	0	BARD1	4	affinity chromatography technology, pull down, affinity chromatography technology	Yang Q (2016), Yang Q (2016), Yang Q (2016)	3
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
RXRA	1	RNF8	2	two hybrid, pull down, fluorescent resonance energy transfe	Takano Y (2004), Takano Y (2004), Takano Y (2004)	3
DYRK2	1	RNF8	2	affinity chromatography technology	Yamamoto T (2017)	1
RNF8	2	MDC1	8	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Huen MS (2007), Mailand N (2007), Mailand N (2007), Kolas NK (2007), Kolas NK (2007), Watanabe S (2013), Henriksson S (2014), Henriksson S (2014), Rassoolzadeh H (2015)	9
TRIM25	5	RXRA	1	affinity chromatography technology	Choudhury NR (2017)	1
MAGED1	0	PCNA	0	affinity chromatography technology, affinity chromatography technology	Yang Q (2014), Yang Q (2014)	2
TRIM25	5	VRK1	0	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	SUMO3	0	affinity chromatography technology	Sahin U (2014)	1
BARD1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down	Mallery DL (2002), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Nhukeaw T (2014), Thakar A (2010)	6
MDC1	8	MDM2	2	unspecified method, affinity chromatography technology	Rodriguez M (2003), Inoue K (2008)	2
BARD1	4	HIST2H2AC	1	enzymatic study	Thakar A (2010)	1
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
FOXM1	3	RNF8	2	affinity chromatography technology, affinity chromatography technology	Kongsema M (2016), Kongsema M (2016)	2
MDM2	2	UBE2N	1	pull down	David Y (2011)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
XRCC5	5	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matheos D (2002), Ohta S (2002), Balajee AS (2001)	3
BCL10	0	UBE2V2	0	pull down	Zhou H (2004)	1
RNF8	2	KDM4A	3	enzymatic study	Mallette FA (2012)	1
VCP	6	UBE2S	2	affinity chromatography technology	Yu CC (2013)	1
UBC	7	HERC2	9	affinity chromatography technology, pull down	Rendtlew Danielsen J (2012), Zhang X (2017)	2
RNF8	2	SEPT3	1	two hybrid	Rolland T (2014)	1
DYRK2	1	MDM2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Taira N (2010), Taira N (2010), Taira N (2010)	3
SUMO2	0	HOMEZ	2	two hybrid	Rolland T (2014)	1
MDC1	8	NBN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, pull down, affinity chromatography technology, imaging technique	Xu X (2003), Goldberg M (2003), Goldberg M (2003), Lukas C (2004), Cha H (2010), Stewart GS (2003), Stewart GS (2003), Stewart GS (2003), Lou Z (2004), Hari FJ (2010), Lu CS (2012), Wu L (2008), Wu L (2008), Wu L (2008), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008)	18
BARD1	4	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Wu W (2007), David Y (2011), Kentsis A (2002), Kleiman FE (2005), Wenzel DM (2011), Chen A (2002), Wu-Baer F (2010)	7
RNF8	2	UBE2D3	1	pull down, pull down, pull down, two hybrid	Mallette FA (2012), Zhang S (2008), Zhang S (2013), Schimmack G (2017)	4
POLD4	0	PCNA	0	pull down, far western blotting, pull down	Li H (2006), Li H (2006), Terai K (2013)	3
MDM2	2	MRE11	3	affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005)	2
RNF8	2	BARD1	4	affinity chromatography technology	Yang Q (2016)	1
UBE2E2	1	RNF8	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ito K (2001), Bekker-Jensen S (2010), Lok GT (2011), Lok GT (2011), Ito K (2001)	5
DYRK2	1	UBE2D1	0	pull down	Jung HY (2013)	1
RNF8	2	CEP44	2	two hybrid	Rual JF (2005)	1
NBN	1	RNF8	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Lu CS (2012), Lu CS (2012), Monsalve DM (2016)	3
RNF8	2	CHD4	22	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Luijsterburg MS (2012), Luijsterburg MS (2012), Luijsterburg MS (2012), Qi W (2016)	4
RNF8	2	TMEM79	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TNF	0	UBE2N	1	genetic interference, affinity chromatography technology	Deng L (2000), Fritsch J (2014)	2
XRCC5	5	NBN	1	affinity chromatography technology	Falck J (2005)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
MRE11	3	RNF8	2	affinity chromatography technology	Lu CS (2012)	1
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
RNF8	2	H3F3B	0	affinity chromatography technology, pull down, enzymatic study	Xia Y (2017), Xia Y (2017), Xia Y (2017)	3
USP16	0	HERC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Zhang Z (2014), Zhang Z (2014), Huttlin EL (2017)	4
RNF8	2	BLM	2	enzymatic study, pull down	Tikoo S (2013), Tikoo S (2013)	2
BARD1	4	UBE2E1	1	pull down	David Y (2011)	1
TRIM25	5	FOXM1	3	affinity chromatography technology	Choudhury NR (2017)	1
SUMO2	0	NBN	1	pull down	Ouyang J (2009)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
MDC1	8	XRCC5	5	pull down, affinity chromatography technology	Lou Z (2004), Lou Z (2004)	2
MDC1	8	H2AFX	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, imaging technique	Stewart GS (2003), Stewart GS (2003), Xu X (2003), Lukas C (2004), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Stewart GS (2003), Stewart GS (2003), Pan MR (2011), Pei H (2011), Campbell SJ (2010), Rassoolzadeh H (2015)	13
SUMO2	0	RAD50	3	pull down	Ouyang J (2009)	1
TRIM25	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
SEPT8	1	RNF8	2	affinity chromatography technology	Chahwan R (2013)	1
WASL	2	RNF8	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
BLM	2	VCP	6	genetic interference	Vizeacoumar FJ (2013)	1
MRE11	3	BLM	2	biochemical	Wang Y (2000)	1
SUMO3	0	RNF8	2	pull down, affinity chromatography technology, imaging technique	Liang L (2017), Liang L (2017), Liang L (2017)	3
RNF8	2	XRCC5	5	affinity chromatography technology	Feng L (2012)	1
MDM2	2	UBE2E2	1	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
UBE2S	2	UBE2D3	1	affinity chromatography technology	Kuang P (2016)	1
UBE2N	1	HERC2	9	affinity chromatography technology, pull down	Bekker-Jensen S (2010), Bai B (2016)	2
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
CHEK2	2	MDM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Pereg Y (2006), Kass EM (2009), Kass EM (2009), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005)	7
UBC	7	MRE11	3	affinity chromatography technology	Matsumoto M (2005)	1
HIST2H2BE	1	UBC	7	pull down	Long L (2014)	1
SUMO2	0	BLM	2	two hybrid	Hecker CM (2006)	1
TRIM25	5	TNFRSF1A	3	affinity chromatography technology	Choudhury NR (2017)	1
RNF8	2	CHEK2	2	affinity chromatography technology, enzymatic study	Feng L (2012), Feng L (2012)	2
TRIM25	5	RBFOX2	5	affinity chromatography technology	Choudhury NR (2017)	1
RNF8	2	PNMA2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
MDC1	8	TP53BP1	3	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, imaging technique, affinity chromatography technology	Eliezer Y (2009), Eliezer Y (2009), Eliezer Y (2009), Wood JL (2007), Stewart GS (2003), Stewart GS (2003)	6
USP16	0	UBC	7	unspecified method, enzymatic study, pull down, unspecified method, pull down, pull down	Pai MT (2007), Faesen AC (2011), Kovacs JJ (2004), Ernst A (2013), Zhang X (2017), Kwasna D (2018)	6
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
VRK1	0	HIST2H2BE	1	pull down	Kang TH (2007)	1
TP53BP1	3	BLM	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Sengupta S (2004), Sengupta S (2004), Sengupta S (2004)	3
TRIM25	5	PCNA	0	affinity chromatography technology, affinity chromatography technology	Park JM (2014), Park JM (2014)	2
UBE2E3	0	RNF8	2	two hybrid, pull down	Ito K (2001), Ito K (2001)	2
RNF8	2	RNF8	2	enzymatic study, enzymatic study, enzymatic study	Ito K (2001), Feng L (2012), Paul A (2017)	3
UBC	7	MAD1L1	2	pull down	Nathan JA (2013)	1
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
H2AFX	1	UBC	7	affinity chromatography technology	Sharma N (2013)	1
CHEK2	2	RAD50	3	affinity chromatography technology	Matsuoka S (2007)	1
BARD1	4	RAD50	3	biochemical, affinity chromatography technology	Greenberg RA (2006), Greenberg RA (2006)	2
UBE2S	2	XRCC5	5	affinity chromatography technology	Hu L (2017)	1
MDM2	2	RNF8	2	two hybrid	Woodsmith J (2012)	1
MDM2	2	UBE2E3	0	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
RNF8	2	HIST2H2BE	1	enzymatic study	Mattiroli F (2012)	1
UBC	7	EXOSC2	2	affinity chromatography technology	Matsumoto M (2005)	1
SEPT7	0	SEPT8	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
NBN	1	RAD50	3	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cerosaletti KM (2003), Trujillo KM (1998), Desai-Mehta A (2001), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Nakanishi K (2002), Greenberg RA (2006), Falck J (2005), Wu J (2012), Alt JR (2005), Havugimana PC (2012), Wan C (2015), Suhasini AN (2013), Suhasini AN (2013), Lee KY (2015)	17
RNF8	2	H2AFX	1	enzymatic study, enzymatic study, imaging technique	Mattiroli F (2012), Yu M (2016), Liang L (2017)	3
NBN	1	H2AFX	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kobayashi J (2002), Kobayashi J (2002), Park JH (2006), Cheng WH (2005), Lukas C (2004), Kobayashi J (2002), Kobayashi J (2002), Pan MR (2011), Kobayashi J (2012)	9
UBE2D3	1	PCNA	0	enzymatic study	Hibbert RG (2012)	1
BARD1	4	NBN	1	biochemical, affinity chromatography technology	Greenberg RA (2006), Greenberg RA (2006)	2
SEPT3	1	SEPT7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
PCNA	0	RPSA	2	affinity chromatography technology	Naryzhny SN (2010)	1
MAD1L1	2	RNF8	2	two hybrid	Rolland T (2014)	1
UBE2W	0	RNF8	2	two hybrid	Markson G (2009)	1
MDC1	8	HERC2	9	affinity chromatography technology	Bekker-Jensen S (2010)	1
TP53BP1	3	RNF8	2	imaging technique	Galanty Y (2009)	1
YEATS4	0	RNF8	2	two hybrid, two hybrid	Piccinni E (2011), Piccinni E (2011)	2
NBN	1	BLM	2	biochemical	Wang Y (2000)	1
MAD1L1	2	TRIM29	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
BARD1	4	MRE11	3	affinity chromatography technology	Greenberg RA (2006)	1
NBN	1	VRK1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Monsalve DM (2016), Monsalve DM (2016), Monsalve DM (2016)	3
TRIM25	5	UBE2S	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Choudhury NR (2017)	2
UBE2N	1	RNF8	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, two hybrid	Markson G (2009), Bekker-Jensen S (2010), Lok GT (2011), Lok GT (2011), Campbell SJ (2012), Plans V (2006), Plans V (2006), Huen MS (2008), Zhang X (2013), Guerra-Rebollo M (2012), Zhao H (2014), Hodge CD (2015), Ho YK (2015), Weber E (2017), Weber E (2017), Schimmack G (2017)	16
VCP	6	RBFOX2	5	affinity chromatography technology	Yu CC (2013)	1
UBE2E1	1	RNF8	2	two hybrid, pull down	Ito K (2001), Ito K (2001)	2
MDC1	8	EXOSC2	2	affinity chromatography technology	Woods NT (2012)	1
MAGED1	0	RBFOX2	5	two hybrid	Rolland T (2014)	1
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
RNF8	2	HIST2H2AC	1	enzymatic study, enzymatic study	Mattiroli F (2012), Paul A (2017)	2
TRIM25	5	RPSA	2	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
MRE11	3	RAD50	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Chiba N (2001), Chiba N (2001), Dolganov GM (1996), Dolganov GM (1996), Trujillo KM (1998), Goedecke W (1999), Zheng L (2009), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Cho YW (2007), Greenberg RA (2006), Alt JR (2005), Alt JR (2005), Havugimana PC (2012), Wan C (2015), Wijnhoven P (2015), Boldt K (2016), Suhasini AN (2013), Suhasini AN (2013), Lee KY (2015), Nicholson J (2017)	25
SUMO2	0	XRCC5	5	pull down	Ouyang J (2009)	1
BARD1	4	UBE2N	1	pull down	David Y (2011)	1
BLM	2	H2AFX	1	affinity chromatography technology, imaging technique	Sengupta S (2004), Sengupta S (2004)	2
MGMT	1	RNF8	2	affinity chromatography technology	Niture SK (2005)	1
VCP	6	TP53BP1	3	affinity chromatography technology	Yu CC (2013)	1
RNF8	2	UBE2S	2	affinity chromatography technology	Paul A (2017)	1
TNFRSF1A	3	RNF8	2	affinity chromatography technology, affinity chromatography technology	Fritsch J (2014), Fritsch J (2014)	2
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
MDM2	2	RAD50	3	affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005)	2
TP53BP1	3	XRCC5	5	affinity chromatography technology	Woods NT (2012)	1
VCP	6	CHEK2	2	affinity chromatography technology	Matsuoka S (2007)	1
TRIM25	5	RNF8	2	affinity chromatography technology	Choudhury NR (2017)	1
MDC1	8	CHEK2	2	affinity chromatography technology, pull down	Lou Z (2003), Lou Z (2003)	2
CHEK2	2	TP53BP1	3	affinity chromatography technology	Matsuoka S (2007)	1
NBN	1	MRE11	3	biochemical, affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cerosaletti KM (2003), Trujillo KM (1998), Matsuzaki K (2008), Desai-Mehta A (2001), Desai-Mehta A (2001), Desai-Mehta A (2001), Zheng L (2009), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Nakanishi K (2002), Shimada M (2009), Shimada M (2009), Yanagihara H (2011), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Alt JR (2005), Havugimana PC (2012), Wijnhoven P (2015), Suhasini AN (2013), Suhasini AN (2013), Nicholson J (2017)	26
SUMO2	0	MDC1	8	pull down	Ouyang J (2009)	1
RNF8	2	RBFOX2	5	two hybrid	Rolland T (2014)	1
WRAP53	1	MDC1	8	affinity chromatography technology, imaging technique, affinity chromatography technology	Henriksson S (2014), Rassoolzadeh H (2015), Rassoolzadeh H (2015)	3
H2AFX	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo K (2008), Heo K (2008), Sand-Dejmek J (2011)	3
HERC2	9	UBE2D3	1	pull down	Wu W (2010)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
UBE2S	2	UBC	7	enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study	Bremm A (2010), Wickliffe KE (2011), Wickliffe KE (2011), Kelly A (2014), Michel MA (2017)	5
MDM2	2	HIST2H2BE	1	pull down, affinity chromatography technology, enzymatic study	Minsky N (2004), Minsky N (2004), Minsky N (2004)	3
MDC1	8	BARD1	4	affinity chromatography technology	Lou Z (2003)	1
RNF8	2	USP16	0	affinity chromatography technology, affinity chromatography technology	Zhang Z (2014), Zhang Z (2014)	2
TRIM25	5	HOMEZ	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM29	2	UBE2E1	1	pull down	Xing J (2016)	1
RNF8	2	UBE2V2	0	pull down	Campbell SJ (2012)	1
RAD50	3	BLM	2	biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Acharya S (2014), Acharya S (2014)	3
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
RNF8	2	SUMO2	0	two hybrid, pull down, affinity chromatography technology, imaging technique	Liang L (2017), Liang L (2017), Liang L (2017), Liang L (2017)	4
CHEK2	2	BLM	2	genetic interference	Srivas R (2016)	1
TRIM29	2	RNF8	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang H (2015), Yang H (2015), Yang H (2015), Yang H (2015)	4
VCP	6	SUMO2	0	affinity chromatography technology	Yu CC (2013)	1
RNF8	2	HERC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bekker-Jensen S (2010), Bekker-Jensen S (2010), Bekker-Jensen S (2010), Rendtlew Danielsen J (2012), Guerra-Rebollo M (2012), Zhang Z (2014)	6
SUMO2	0	MRE11	3	pull down	Ouyang J (2009)	1
MDC1	8	MRE11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Xu X (2003), Xu X (2003), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Stewart GS (2003), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008)	10
MAGED1	0	RNF8	2	affinity chromatography technology, pull down, affinity chromatography technology	Yang Q (2016), Yang Q (2016), Yang Q (2016)	3
TRIM25	5	HERC2	9	affinity chromatography technology	Choudhury NR (2017)	1
MGMT	1	PCNA	0	affinity chromatography technology	Niture SK (2005)	1
H2AFX	1	HIST2H2AC	1	affinity chromatography technology	Lee HS (2010)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
WRAP53	1	H2AFX	1	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Henriksson S (2014), Rassoolzadeh H (2015), Rassoolzadeh H (2015), Rassoolzadeh H (2015)	4
VCP	6	MDM2	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Okoro DR (2013)	2
VCP	6	RNF8	2	two hybrid	Rolland T (2014)	1
BARD1	4	UBE2E3	0	pull down	David Y (2011)	1
MDM2	2	NBN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005), Bouska A (2008)	3
RNF8	2	UBE2D1	0	pull down, pull down	Ito K (2001), Feng L (2012)	2
PCNA	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Groehler AL (2010), Banks D (2006)	2
RNF8	2	CCDC85B	0	two hybrid	Rual JF (2005)	1
BARD1	4	UBE2E2	1	pull down	David Y (2011)	1
SEPT3	1	SEPT8	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EXOSC2	2	RNF8	2	two hybrid	Lehner B (2004)	1
USP16	0	HIST2H2AC	1	enzymatic study, enzymatic study	Joo HY (2007), Draker R (2011)	2
TNF	0	RNF8	2	affinity chromatography technology	Fritsch J (2014)	1
BARD1	4	EXOSC2	2	affinity chromatography technology	Woods NT (2012)	1
SEPT7	0	RNF8	2	affinity chromatography technology	Chahwan R (2013)	1
UBE2N	1	NBN	1	pull down	Lu CS (2012)	1
RNF8	2	RPSA	2	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Guerra-Rebollo M (2012), Guerra-Rebollo M (2012), Guerra-Rebollo M (2012), Guerra-Rebollo M (2012)	4
RNF8	2	PCNA	0	enzymatic study, affinity chromatography technology, enzymatic study	Zhang S (2008), Zhang S (2008), Mattiroli F (2012)	3
TP53BP1	3	UBC	7	affinity chromatography technology	Benada J (2015)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
H2AFX	1	RAD50	3	imaging technique, affinity chromatography technology	Paull TT (2000), Lukas C (2004)	2
UBC	7	CHD4	22	affinity chromatography technology	Matsumoto M (2005)	1
RNF8	2	VRK1	0	affinity chromatography technology	Monsalve DM (2016)	1
RNF8	2	HOMEZ	2	two hybrid	Rolland T (2014)	1
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
H2AFX	1	MRE11	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Lukas C (2004), Kobayashi J (2002), Kobayashi J (2002)	3
RNF8	2	BCL10	0	affinity chromatography technology	Zhao H (2014)	1
SUMO2	0	CHD4	22	pull down	Ouyang J (2009)	1
RNF8	2	JMJD1C	10	pull down, affinity chromatography technology	Watanabe S (2013), Watanabe S (2013)	2