PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCC	3	CBR1	0	affinity chromatography technology	Ewing RM (2007)	1
COPS5	0	ESR1	0	affinity chromatography technology	Callige M (2005)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	FH	0	two hybrid	Wang J (2008)	1
CBR1	0	SEC61B	0	affinity chromatography technology	Hein MY (2015)	1
CFTR	5	MYH1	2	affinity chromatography technology	Pankow S (2015)	1
APBA3	2	EGFR	5	unspecified method	Jones RB (2006)	1
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
ESR1	0	SEC61B	0	affinity chromatography technology	Tarallo R (2011)	1
PRKAB1	0	CBR1	0	affinity chromatography technology	Behrends C (2010)	1
COPS5	0	CBR1	0	affinity chromatography technology	Bennett EJ (2010)	1
FH	0	CBR1	0	biochemical	Wan C (2015)	1
NTRK1	1	COPS5	0	affinity chromatography technology	Emdal KB (2015)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
CBR1	0	PLEKHM2	3	affinity chromatography technology	Hein MY (2015)	1
UBC	7	FAF2	4	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Alexandru G (2008)	2
NXF1	0	GOT1	2	affinity chromatography technology	Castello A (2012)	1
EGFR	5	FAF2	4	affinity chromatography technology	Tong J (2014)	1
NTRK1	1	OTUB1	0	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
NXF1	0	PPHLN1	0	affinity chromatography technology	Castello A (2012)	1
DDA1	1	CBR1	0	affinity chromatography technology	Behrends C (2010)	1
CUL1	7	NCBP2	0	affinity chromatography technology	Bennett EJ (2010)	1
SEC61B	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, biochemical	Liao HJ (2009), Wang YN (2010), Wang YN (2010)	3
CUL1	7	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
CBR1	0	TMEM208	0	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	PRKAB1	0	two hybrid, affinity chromatography technology	Wang J (2008), Wang J (2008)	2
NTRK1	1	RAD21	3	affinity chromatography technology	Emdal KB (2015)	1
ATG101	1	UBA5	0	affinity chromatography technology	Behrends C (2010)	1
CBR1	0	WAC	18	affinity chromatography technology	Hein MY (2015)	1
UBA5	0	NCBP2	0	affinity chromatography technology	Hein MY (2015)	1
CBR1	0	FAF2	4	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
EGFR	5	GOT1	2	protein complementation assay	Deribe YL (2009)	1
CBR1	0	PPHLN1	0	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	VHL	0	affinity chromatography technology	Bemis L (2004)	1
CUL7	4	UBC	7	affinity chromatography technology	Hanson D (2014)	1
NTRK1	1	RBM12	6	affinity chromatography technology	Emdal KB (2015)	1
NXF1	0	RBM12	6	affinity chromatography technology	Castello A (2012)	1
CFTR	5	NCBP2	0	affinity chromatography technology	Pankow S (2015)	1
UBC	7	CBR3	4	pull down	Nathan JA (2013)	1
NTRK1	1	CUL1	7	affinity chromatography technology	Emdal KB (2015)	1
CUL1	7	ESR1	0	affinity chromatography technology	Zhou W (2014)	1
CBR1	0	TXNL4A	0	affinity chromatography technology	Hein MY (2015)	1
UBC	7	CBR1	0	pull down	Nathan JA (2013)	1
UBA5	0	CBR1	0	affinity chromatography technology	Behrends C (2010)	1
GRB2	2	CBR1	0	affinity chromatography technology	Blagoev B (2003)	1
CBR1	0	NCBP2	0	affinity chromatography technology	Hein MY (2015)	1
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
RAD21	3	UBC	7	affinity chromatography technology	Panigrahi AK (2011)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
NXF1	0	UBC	7	affinity chromatography technology	Castello A (2012)	1
NXF1	0	CBR1	0	affinity chromatography technology	Castello A (2012)	1
VHL	0	CBR1	0	pull down	Lai Y (2012)	1
VHL	0	MCC	3	affinity chromatography technology	Ewing RM (2007)	1
OTUB1	0	SEC61B	0	affinity chromatography technology	Scholz CC (2016)	1
UBC	7	MYH1	2	affinity chromatography technology	Matsumoto M (2005)	1
CBR1	0	DENND3	5	affinity chromatography technology	Hein MY (2015)	1
OTUB1	0	CBR1	0	affinity chromatography technology	Scholz CC (2016)	1
ESR1	0	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Stanisic V (2009), Stanisic V (2009), Stanisic V (2009)	3
GOT1	2	CBR1	0	biochemical	Wan C (2015)	1
CUL1	7	CBR1	0	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
UBC	7	RBM12	6	affinity chromatography technology	Matsumoto M (2005)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
NTRK1	1	CBR1	0	affinity chromatography technology	Emdal KB (2015)	1
CFTR	5	FAF2	4	affinity chromatography technology	Pankow S (2015)	1
CUL7	4	CBR1	0	affinity chromatography technology	Hanson D (2014)	1
ATG101	1	CBR1	0	affinity chromatography technology	Behrends C (2010)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
CBR1	0	ZNF518A	5	affinity chromatography technology	Hein MY (2015)	1
CBR3	4	CBR1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
ESR1	0	CBR1	0	affinity chromatography technology, affinity chromatography technology	Kanaujiya JK (2013), Han SJ (2016)	2
EGFR	5	CBR1	0	protein complementation assay	Deribe YL (2009)	1
CFTR	5	CBR1	0	affinity chromatography technology	Pankow S (2015)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
CBR1	0	RBM12	6	biochemical	Wan C (2015)	1
CBR1	0	CBR1	0	x-ray crystallography	Liang Q (2015)	1
COPS5	0	DDA1	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
RAD21	3	CBR1	0	affinity chromatography technology	Panigrahi AK (2011)	1
FAF2	4	CUL1	7	affinity chromatography technology	Alexandru G (2008)	1
CBR1	0	ZC3H13	8	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
CBR1	0	MYH1	2	affinity chromatography technology	Hein MY (2015)	1
FH	0	GOT1	2	biochemical	Wan C (2015)	1
CBR1	0	APBA3	2	affinity chromatography technology	Hein MY (2015)	1
CBR1	0	ICAM5	0	affinity chromatography technology	Hein MY (2015)	1