Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CBR1	873	WEDELOLACTONE	CHEMBL97453	inhibitor	GuideToPharmacologyInteractions
CBR1	873	CHEMBL3277946	CHEMBL3277946		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CBR1	rs9024	GG	doxorubicin	metabolism/PK	yes		Genotype GG is associated with increased clearance of doxorubicin in people with Breast Neoplasms as compared to genotype AG.	19016765	1448105610
CBR1	rs20572	CC	doxorubicin	metabolism/PK	yes		Genotype CC is associated with decreased concentrations of doxorubicin in people with Breast Neoplasms as compared to genotype CT.	19016765	1448105661
CBR1	rs20572	CC	doxorubicin	metabolism/PK	yes		Genotype CC is associated with decreased exposure to doxorubicin in people with Breast Neoplasms as compared to genotype CT.	19016765	1448105654
CBR1	rs25678	CC	daunorubicin	metabolism/PK	yes	as measured by lower AUC of daunorubicin. Patients who achieved complete remission (CR) had significantly lower plasma Daunorubicin AUC, but relationship of variant and clinical outcome was not tested.	Genotype CC is associated with decreased exposure to daunorubicin in people with Leukemia, Myeloid, Acute as compared to genotypes CG + GG.	27738808	1448635343
CBR1	rs9024	GG	doxorubicin	metabolism/PK	yes		Genotype GG is associated with decreased concentrations of doxorubicin in people with Breast Neoplasms as compared to genotype AG.	19016765	1448105620
CBR1	rs9024	GG	doxorubicin	metabolism/PK	yes		Genotype GG is associated with decreased exposure to doxorubicin in people with Breast Neoplasms as compared to genotype AG.	19016765	1448105627
CBR1	rs20572	CC	doxorubicin	metabolism/PK	yes		Genotype CC is associated with increased clearance of doxorubicin in people with Breast Neoplasms as compared to genotype CT.	19016765	1448105647