PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	KIF1C	0	affinity chromatography technology	Choudhury NR (2017)	1
LLGL2	4	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
EIF4G1	9	EIF4G2	7	biochemical	Havugimana PC (2012)	1
TRIM25	5	MAPK14	0	affinity chromatography technology	Choudhury NR (2017)	1
MKNK1	0	PAK2	0	imaging technique	Chen TC (2014)	1
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
DNAJC7	2	PRKDC	12	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	PPIA	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
XPO1	8	PHAX	0	affinity chromatography technology	Kirli K (2015)	1
MAPK3	4	PAK2	0	biochemical	Wan C (2015)	1
MKNK1	0	APP	1	pull down	Olah J (2011)	1
MKNK1	0	EIF4G2	7	affinity chromatography technology	Pyronnet S (1999)	1
HGS	5	MKNK1	0	two hybrid	Wang J (2011)	1
MKNK1	0	ATXN3	2	two hybrid	Vinayagam A (2011)	1
MKNK1	0	MAPK1	1	pull down, two hybrid, pull down	Waskiewicz AJ (1997), Waskiewicz AJ (1997), Smith JA (2000)	3
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
MKNK1	0	HSP90AB1	2	two hybrid	Bandyopadhyay S (2010)	1
EGLN3	0	MKNK1	0	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	TNIP2	1	affinity chromatography technology	Kirli K (2015)	1
PARD6B	0	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
MAPK1	1	CREBBP	29	enzymatic study	Janknecht R (1996)	1
BOD1L1	11	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
TRIM25	5	PRKDC	12	affinity chromatography technology	Choudhury NR (2017)	1
MAPK14	0	MKNK1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	7
XPO1	8	EIF4G2	7	affinity chromatography technology	Kirli K (2015)	1
PAK2	0	APP	1	pull down	Olah J (2011)	1
XPO1	8	MKNK1	0	affinity chromatography technology	Kirli K (2015)	1
MKNK1	0	DNAJC7	2	two hybrid	Bandyopadhyay S (2010)	1
MKNK1	0	PRKDC	12	two hybrid	Bandyopadhyay S (2010)	1
EGLN3	0	PRKDC	12	affinity chromatography technology	Rodriguez J (2016)	1
MKNK1	0	EIF4G3	3	two hybrid	Vinayagam A (2011)	1
MAPK3	4	MKNK1	0	enzymatic study	Fukunaga R (1997)	1
MAPK3	4	CREBBP	29	enzymatic study	Tsai LN (2008)	1
MAPK11	1	MAPK14	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013)	2
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
PPIA	0	APP	1	pull down	Olah J (2011)	1
MKNK1	0	EIF4E	1	affinity chromatography technology	Pyronnet S (1999)	1
MKNK1	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
KIF18A	3	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
MAPK14	0	PAK2	0	affinity chromatography technology	Chan PM (2008)	1
FANCA	5	MKNK1	0	two hybrid	Reuter TY (2003)	1
EGLN3	0	MAPK1	1	two hybrid	Wang J (2011)	1
EIF4E	1	APP	1	pull down	Olah J (2011)	1
MKNK1	0	RCN3	0	two hybrid	Wang J (2011)	1
MOV10	6	HGS	5	affinity chromatography technology	Castello A (2012)	1
KIF1C	0	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
EIF4G2	7	EIF4G3	3	biochemical	Havugimana PC (2012)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
RAB5A	0	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
MAPK11	1	MKNK1	0	affinity chromatography technology	Varjosalo M (2013)	1
EIF4G1	9	EIF4G3	3	biochemical	Havugimana PC (2012)	1
MYH13	9	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HIPK2	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
PPIA	0	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
MKNK1	0	SPRY2	4	affinity chromatography technology, enzymatic study	DaSilva J (2006), DaSilva J (2006)	2
MAPK11	1	APP	1	pull down	Olah J (2011)	1
PARD6B	0	LLGL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hutchins JR (2010), Huttlin EL (2015), Hauri S (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
RNASEH2B	0	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	APP	1	pull down	Olah J (2011)	1
MKNK1	0	PHAX	0	two hybrid	Vinayagam A (2011)	1
FANCA	5	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, genetic interference	Karras GI (2017), Karras GI (2017), Karras GI (2017)	3
HIPK2	0	MKNK1	0	two hybrid	Wang J (2011)	1
CREBBP	29	UBE2D1	0	pull down	Shi D (2009)	1
DNAJC7	2	HSP90AB1	2	affinity chromatography technology	Hein MY (2015)	1
MKNK1	0	EIF4G1	9	affinity chromatography technology, pull down	Pyronnet S (1999), Pyronnet S (1999)	2
MAPK1	1	TNIP2	1	two hybrid	Wang J (2011)	1
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
PDK1	1	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
MKNK1	0	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
EGLN3	0	SPRY2	4	affinity chromatography technology	Anderson K (2011)	1
MOV10	6	RAB5A	0	biochemical	Havugimana PC (2012)	1
HSP90AB1	2	PRKDC	12	affinity chromatography technology	Falsone SF (2005)	1
TNIP2	1	APP	1	pull down	Olah J (2011)	1
HIPK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Hofmann TG (2002), Hofmann TG (2002)	2
ATXN3	2	APP	1	pull down	Olah J (2011)	1
MKNK1	0	CREBBP	29	two hybrid	Bandyopadhyay S (2010)	1
TRIM25	5	EIF4G1	9	affinity chromatography technology	Choudhury NR (2017)	1
ATXN3	2	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology	Li F (2002), Li F (2002), Li Y (2007)	3
MOV10	6	MKNK1	0	affinity chromatography technology	Castello A (2012)	1
EIF4E	1	EIF4G1	9	affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Vary TC (1999), Mader S (1995), Connolly E (2006), Harris TE (2006), Kumar V (2000), Connolly E (2006), Harris TE (2006), Murata T (2006), Kroczynska B (2012), Choo AY (2008), Petersson J (2012), Huttlin EL (2015), Wan C (2015), Gradi A (1998), Huttlin EL (2017), Martinez A (2015)	16
HGS	5	SPRY2	4	affinity chromatography technology	Kim HJ (2007)	1
EIF4E	1	EIF4G3	3	affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Gradi A (1998), Gradi A (1998), Huttlin EL (2017)	5
MAPK14	0	MAPK3	4	affinity chromatography technology, protein complementation assay	Sanz-Moreno V (2003), Srivastav RK (2011)	2
EGLN3	0	DNAJC7	2	affinity chromatography technology	Rodriguez J (2016)	1
ID1	0	MKNK1	0	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1
MKNK1	0	TNIP2	1	two hybrid	Wang J (2011)	1
TRIM25	5	MKNK1	0	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AB1	2	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1