PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDE4DIP	10	TFIP11	5	two hybrid	Rolland T (2014)	1
CSNK2B	5	GSK3B	1	two hybrid	Wallach T (2013)	1
RBPMS	0	TINAGL1	0	two hybrid	Rolland T (2014)	1
CSNK2B	5	TP53BP2	5	two hybrid	Vinayagam A (2011)	1
NXF1	0	TFIP11	5	affinity chromatography technology	Castello A (2012)	1
HDAC2	1	ESR1	0	affinity chromatography technology, affinity chromatography technology	Itoh Y (2007), Tarallo R (2011)	2
LMO4	1	DEAF1	12	two hybrid	Sum EY (2002)	1
HDAC1	4	ESR1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Kawai H (2003), Kawai H (2003), Varshochi R (2005), Varshochi R (2005), Kurtev V (2004), Liu XF (2004), Itoh Y (2007), Tarallo R (2011), Yoshimaru T (2013)	9
TNFSF11	0	PLK1	0	two hybrid	Vinayagam A (2011)	1
AES	2	KANK2	4	two hybrid	Rolland T (2014)	1
LMO4	1	ZBTB43	1	two hybrid	Rolland T (2014)	1
SSBP2	2	SSBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSNK2B	5	BRCA1	7	pull down, two hybrid, pull down	OBrien KA (1999), OBrien KA (1999), OBrien KA (1999)	3
LMO4	1	AMOT	6	two hybrid	Rolland T (2014)	1
HDAC1	4	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yao YL (2003), Yao YL (2003), Yao YL (2003), Mazumdar A (2001), Mazumdar A (2001), Yoo YG (2006), Liu XF (2004), Khaleque MA (2008), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016)	21
PPARG	0	LMO4	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Schock SC (2008), Schock SC (2008), Schock SC (2008), Schock SC (2008)	4
LMO4	1	RBPMS	0	two hybrid	Rolland T (2014)	1
LMO4	1	KIAA1958	5	two hybrid	Rolland T (2014)	1
SMAD9	0	TINAGL1	0	two hybrid	Colland F (2004)	1
TP53BP2	5	NXF1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Castello A (2012)	2
RBPMS	0	BANP	1	two hybrid	Rolland T (2014)	1
BRCA1	7	HDAC2	1	pull down, affinity chromatography technology, genetic interference	Yarden RI (1999), Chang S (2011), Shen JP (2017)	3
HDAC2	1	LMO4	1	pull down, affinity chromatography technology	Singh RR (2005), Singh RR (2005)	2
GADD45A	1	ESR1	0	affinity chromatography technology	Yi YW (2000)	1
SMAD4	9	SMAD9	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Nishita M (1999), Li X (2015)	3
LDB1	2	SSBP3	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
KRT15	2	AMOTL2	5	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
LMO4	1	KRT40	0	two hybrid	Rolland T (2014)	1
AES	2	GOLGA2	2	two hybrid	Rolland T (2014)	1
AMOT	6	TP53BP2	5	bioid	Couzens AL (2013)	1
MTA1	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Mazumdar A (2001), Mazumdar A (2001), Mazumdar A (2001), Li DQ (2010), Yan C (2003), Balasenthil S (2007), Ohshiro K (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	16
CSNK2B	5	ITSN1	5	two hybrid	Vinayagam A (2011)	1
MOV10	6	PITPNB	1	affinity chromatography technology	Castello A (2012)	1
LMO4	1	CALCOCO2	0	two hybrid	Rolland T (2014)	1
AES	2	KRT15	2	two hybrid	Rolland T (2014)	1
LMO4	1	KPNA1	5	two hybrid	Colland F (2004)	1
LMO4	1	TSEN15	0	two hybrid	Colland F (2004)	1
NONO	3	HDAC2	1	affinity chromatography technology	Zhang C (2008)	1
NXF1	0	KIF3B	3	affinity chromatography technology	Castello A (2012)	1
IDI2	0	SSBP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLK1	0	ERCC6L	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Hein MY (2015), Huttlin EL (2017)	3
AES	2	RBPMS	0	two hybrid	Rolland T (2014)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
VPS52	0	KANK2	4	two hybrid	Rolland T (2014)	1
LMO4	1	BANP	1	two hybrid	Rolland T (2014)	1
SSBP4	0	LMO4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IDI2	0	SSBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB1	6	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ji Q (2014), Ji Q (2014), Zhao R (2014), Romani B (2016)	4
NXF1	0	HDAC2	1	affinity chromatography technology	Castello A (2012)	1
LMO4	1	HDAC1	4	affinity chromatography technology	Singh RR (2005)	1
PLK1	0	RBBP8	1	affinity chromatography technology	Hein MY (2015)	1
SSBP3	7	LMO4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSBP2	2	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB1	6	NXF1	0	biochemical	Havugimana PC (2012)	1
KRT31	0	AMOTL2	5	two hybrid	Rolland T (2014)	1
LDB2	0	SSBP2	2	two hybrid	DeGrado-Warren J (2008)	1
LMO4	1	LDB2	0	two hybrid, two hybrid	Colland F (2004), DeGrado-Warren J (2008)	2
LMO4	1	PITPNB	1	two hybrid	Colland F (2004)	1
MOV10	6	SSBP4	0	affinity chromatography technology	Castello A (2012)	1
LMO4	1	TCF21	0	two hybrid	Colland F (2004)	1
BRCA1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
GOLGA2	2	AMOTL2	5	two hybrid	Rolland T (2014)	1
LMO4	1	ZNF397	1	two hybrid	Rolland T (2014)	1
NXF1	0	LMO4	1	affinity chromatography technology	Castello A (2012)	1
AES	2	KRT31	0	two hybrid	Rolland T (2014)	1
RBBP8	1	LMO4	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Sum EY (2002), Sum EY (2002), Sum EY (2002), Sutherland KD (2003), Rolland T (2014), Liu H (2015)	6
PLK1	0	HDAC2	1	affinity chromatography technology	Boldt K (2016)	1
LMO4	1	TFIP11	5	two hybrid	Rolland T (2014)	1
MOV10	6	TFIP11	5	affinity chromatography technology	Castello A (2012)	1
PLK1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Zou J (2013), Zou J (2014)	2
GSK3B	1	DEAF1	12	enzymatic study, affinity chromatography technology	Pilot-Storck F (2010), Pilot-Storck F (2010)	2
KRT15	2	AMOT	6	two hybrid	Rolland T (2014)	1
TCF4	26	LMO4	1	two hybrid	Rolland T (2014)	1
GOLGA2	2	KANK2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
KRT15	2	LMO4	1	two hybrid	Rolland T (2014)	1
BRCA1	7	HDAC1	4	pull down	Yarden RI (1999)	1
LMO4	1	TINAGL1	0	two hybrid	Colland F (2004)	1
NXF1	0	PITPNB	1	affinity chromatography technology	Castello A (2012)	1
MOV10	6	AES	2	affinity chromatography technology	Castello A (2012)	1
IDI2	0	LDB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCF21	0	TCF4	26	two hybrid, affinity chromatography technology, affinity chromatography technology	Arab K (2011), Arab K (2011), Arab K (2011)	3
LMO4	1	ZNF675	3	two hybrid	Colland F (2004)	1
MOV10	6	KIF3B	3	affinity chromatography technology	Castello A (2012)	1
NFYC	0	LMO4	1	two hybrid	Bandyopadhyay S (2010)	1
LMO4	1	DDB1	6	two hybrid	Colland F (2004)	1
NXF1	0	CSNK2B	5	affinity chromatography technology	Castello A (2012)	1
MOV10	6	HDAC2	1	affinity chromatography technology	Castello A (2012)	1
MTA1	3	KRT40	0	two hybrid	Rolland T (2014)	1
DDB1	6	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ji Q (2014), Ji Q (2014), Romani B (2016)	3
LDB1	2	ESR1	0	pull down	Johnsen SA (2009)	1
LDB1	2	SSBP2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
KRT31	0	LMO4	1	two hybrid	Rolland T (2014)	1
LMO4	1	ERCC6L	3	two hybrid	Rolland T (2014)	1
LMO4	1	GRHL2	1	two hybrid	Rolland T (2014)	1
GADD45A	1	LMO4	1	two hybrid	Vinayagam A (2011)	1
MOV10	6	LMO4	1	affinity chromatography technology	Castello A (2012)	1
BRCA1	7	MOV10	6	affinity chromatography technology	Ertych N (2016)	1
LDB2	0	SSBP4	0	two hybrid	Ravasi T (2010)	1
BANP	1	HDAC1	4	imaging technique, affinity chromatography technology, imaging technique	Sinha S (2010), Adhikary A (2014), Adhikary A (2014)	3
BRCA1	7	RBBP8	1	unspecified method, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rodriguez M (2003), Li S (1999), Li S (1999), Li S (1999), Wong AK (1998), Wong AK (1998), Li S (2000), Wu-Baer F (2001), Yu X (1998), Yu X (1998), Yu X (2000), Yu X (2000), Yu X (2000), Kim H (2007), Yu X (2006), Yu X (2006), Wu-Baer F (2010), Volcic M (2012), Wang B (2007), Wang B (2007), Furuta S (2006), Furuta S (2006), Drikos I (2009), Tischkowitz M (2008), Li S (2000), Wu-Baer F (2001), Chen L (2008), Sevcik J (2013), Johnson N (2013), Hill SJ (2014), Cruz-Garcia A (2014), Hu Y (2014), Parameswaran B (2015), Liu H (2015), Renaud E (2016)	35
AMOT	6	AMOTL2	5	affinity chromatography technology, bioid	Wells CD (2006), Couzens AL (2013)	2
LMO4	1	ITSN1	5	two hybrid	Colland F (2004)	1
LMO4	1	ESR1	0	pull down, pull down, affinity chromatography technology	Singh RR (2005), Singh RR (2005), Singh RR (2005)	3
SSBP2	2	LMO4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ESR1	0	GOLGA2	2	affinity chromatography technology	Tarallo R (2011)	1
TNFSF11	0	ZNF675	3	genetic interference	Shin JN (2002)	1
AES	2	KRT40	0	two hybrid	Rolland T (2014)	1
LDB1	2	SSBP4	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
LMO4	1	CCDC102B	0	two hybrid	Rolland T (2014)	1
PLK1	0	TP53BP2	5	two hybrid	Vinayagam A (2011)	1
TP53BP2	5	LMO4	1	two hybrid	Rolland T (2014)	1
HDAC1	4	CSNK2B	5	affinity chromatography technology	Joshi P (2013)	1
PLK1	0	ITSN1	5	two hybrid	Vinayagam A (2011)	1
MTA1	3	ESR1	0	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Kumar R (2002), Kumar R (2002), Kumar R (2002), Mazumdar A (2001), Singh RR (2006), Mishra SK (2003)	6
AES	2	CALCOCO2	0	two hybrid	Rolland T (2014)	1
NONO	3	LMO4	1	two hybrid	Rolland T (2014)	1
MTA1	3	LMO4	1	pull down, pull down, affinity chromatography technology	Singh RR (2005), Singh RR (2005), Singh RR (2005)	3
NXF1	0	KRT40	0	two hybrid	Rolland T (2014)	1
LMO4	1	KANK2	4	two hybrid	Rolland T (2014)	1
LMO4	1	LDB1	2	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid	Sutherland KD (2003), Deane JE (2003), Deane JE (2003), Colland F (2004), Rolland T (2014)	5
IDI2	0	LMO4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSBP4	0	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
LMO4	1	AMOTL2	5	two hybrid	Rolland T (2014)	1
DDB1	6	ESR1	0	affinity chromatography technology	Ohtake F (2007)	1
PPARG	0	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yoo EJ (2006), Yoo EJ (2006), Pancione M (2010)	3
NFYC	0	HDAC1	4	affinity chromatography technology	Kato T (2009)	1
LMO4	1	645455	0	two hybrid	Rolland T (2014)	1
PLK1	0	LMO4	1	two hybrid	Vinayagam A (2011)	1
AES	2	LMO4	1	two hybrid	Rolland T (2014)	1
SMAD9	0	LMO4	1	two hybrid	Colland F (2004)	1
RPS6KA6	0	LMO4	1	two hybrid	Vinayagam A (2011)	1
AMOTL2	5	TP53BP2	5	affinity chromatography technology	Couzens AL (2013)	1
SMAD4	9	LMO4	1	two hybrid	Rolland T (2014)	1
CSNK2B	5	LMO4	1	two hybrid	Vinayagam A (2011)	1
IDI2	0	SSBP3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KRT31	0	PDE4DIP	10	two hybrid	Rolland T (2014)	1
PPARG	0	TCF4	26	affinity chromatography technology	Jansson EA (2005)	1
LMO4	1	PDE4DIP	10	two hybrid	Rolland T (2014)	1
LDB2	0	SSBP3	7	two hybrid	DeGrado-Warren J (2008)	1
GSK3B	1	LMO4	1	two hybrid	Vinayagam A (2011)	1
KRT31	0	AMOT	6	two hybrid	Rolland T (2014)	1
GABPB1	0	LMO4	1	two hybrid	Rolland T (2014)	1
BRCA1	7	ESR1	0	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zheng L (2001), Fan S (2001), Fan S (2001), Kawai H (2002), Fan S (2002), Fan S (2002), Nakuci E (2006), Wang C (2005), Wang C (2005), Dizin E (2010), Dizin E (2010), Ma Y (2010), Ma Y (2010), Fan S (2001), Ma YX (2005), Ma YX (2005), Ma YX (2005), Ma Y (2007), Ma Y (2007), Kawai H (2002), Jung YS (2014), Kawai H (2002), Kawai H (2002)	23
HDAC2	1	KPNA1	5	affinity chromatography technology	Joshi P (2013)	1
LMO4	1	SEC24D	4	two hybrid	Colland F (2004)	1
HDAC1	4	NONO	3	imaging technique, affinity chromatography technology, affinity chromatography technology	Dong X (2007), Liu L (2011), Zhang C (2008)	3
LMO4	1	KIF3B	3	two hybrid	Colland F (2004)	1
VPS52	0	LMO4	1	two hybrid	Rolland T (2014)	1
TNFSF11	0	LMO4	1	two hybrid	Vinayagam A (2011)	1
LMO4	1	BRCA1	7	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology	Sum EY (2002), Sum EY (2002), Sum EY (2002), Sum EY (2002), Sum EY (2002), Sutherland KD (2003)	6
HDAC1	4	KPNA1	5	affinity chromatography technology	Joshi P (2013)	1
AES	2	TCF4	26	two hybrid	Rolland T (2014)	1
ESR1	0	NONO	3	pull down	Nalvarte I (2010)	1
GOLGA2	2	LMO4	1	two hybrid	Rolland T (2014)	1