PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AURKB	2	HIST2H2AA3	0	affinity chromatography technology	Joo HY (2007)	1
NOC2L	5	HIST2H2AA3	0	pull down	Hublitz P (2005)	1
RNF2	1	G3BP1	4	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	NOC2L	5	affinity chromatography technology	Cao Q (2014)	1
BMI1	0	G3BP1	4	affinity chromatography technology	Cao Q (2014)	1
OBSL1	9	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
HIST2H2AA3	0	BMI1	0	affinity chromatography technology, enzymatic study	Richly H (2010), Bentley ML (2011)	2
G3BP1	4	HIST2H2AA3	0	affinity chromatography technology	Sowa ME (2009)	1
MAPK8	3	HIST2H2AA3	0	affinity chromatography technology	Hein MY (2015)	1
HIST2H2AA3	0	RNF2	1	affinity chromatography technology, enzymatic study, enzymatic study	Richly H (2010), Bentley ML (2011), Cao Q (2014)	3
UBC	7	BAP1	4	pull down, pull down, pull down, pull down	Duerksen-Hughes PJ (1989), Daou S (2015), Kwasna D (2018), Hanpude P (2017)	4
CUL7	4	NOC2L	5	affinity chromatography technology	Hanson D (2014)	1
EGFR	5	G3BP1	4	affinity chromatography technology	Yao Z (2017)	1
BMI1	0	GEMIN5	1	affinity chromatography technology	Cao Q (2014)	1
HIST2H2AA3	0	PARP1	3	pull down	Messner S (2010)	1
MEN1	1	HIST2H2AA3	0	affinity chromatography technology	Hughes CM (2004)	1
USP16	0	HIST2H2AA3	0	enzymatic study	Joo HY (2007)	1
IL33	2	USP21	2	affinity chromatography technology, affinity chromatography technology	Tao L (2014), Tao L (2014)	2
MAPK8	3	WWOX	3	affinity chromatography technology, two hybrid	Chang NS (2003), Chang NS (2003)	2
USP21	2	BAP1	4	enzymatic study	Loch CM (2012)	1
USP21	2	HIST2H2AA3	0	enzymatic study	Richly H (2010)	1
HDAC1	4	MAPK8	3	affinity chromatography technology	Morrison BE (2006)	1
CUL7	4	APP	1	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	UBC	7	affinity chromatography technology	Hanson D (2014)	1
NOC2L	5	APP	1	pull down	Olah J (2011)	1
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
SUZ12	0	HIST2H2AA3	0	affinity chromatography technology	Cao Q (2014)	1
MAPK8	3	GEMIN5	1	affinity chromatography technology, pull down	Kim EK (2007), Kim EK (2007)	2
MCM5	1	UBC	7	affinity chromatography technology	Drissi R (2015)	1
UBC	7	G3BP1	4	affinity chromatography technology	Matsumoto M (2005)	1
MCM2	3	HIST2H2AA3	0	affinity chromatography technology	Drissi R (2015)	1
OBSL1	9	SRRM1	2	affinity chromatography technology	Hanson D (2014)	1
G3BP1	4	MCM5	1	affinity chromatography technology	Jain S (2016)	1
BMI1	0	RNF2	1	biochemical, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Cao R (2005), Ben-Saadon R (2006), Li Z (2006), Maertens GN (2009), Wei J (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Pan MR (2011), Pan MR (2011), Voncken JW (2005), Woodsmith J (2012), Voncken JW (2003), Woodsmith J (2012), Li Z (2006), Li Z (2006), McGinty RK (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Balasubramanian S (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Abdouh M (2016), Sanchez A (2016), Wheaton K (2017), Hauri S (2016), Hauri S (2016)	30
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
OBSL1	9	MCM5	1	affinity chromatography technology	Hanson D (2014)	1
UBC	7	AURKB	2	affinity chromatography technology	Huang G (2014)	1
USP16	0	UBC	7	unspecified method, enzymatic study, pull down, unspecified method, pull down, pull down	Pai MT (2007), Faesen AC (2011), Kovacs JJ (2004), Ernst A (2013), Zhang X (2017), Kwasna D (2018)	6
CUL7	4	UBC	7	affinity chromatography technology	Hanson D (2014)	1
PARP1	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hassa PO (2005), Hassa PO (2005), Hang CT (2010), Rajamohan SB (2009)	4
HIST2H2AA3	0	HDAC1	4	affinity chromatography technology	Richly H (2010)	1
BMI1	0	PARP1	3	affinity chromatography technology	Facchino S (2010)	1
UBC	7	RNF20	9	affinity chromatography technology	Bish RA (2007)	1
G3BP1	4	APP	1	pull down	Olah J (2011)	1
PDHA1	7	G3BP1	4	affinity chromatography technology	Malty RH (2017)	1
MCM5	1	APP	1	pull down	Olah J (2011)	1
MEN1	1	HDAC1	4	pull down	Kim H (2003)	1
BMI1	0	PRMT6	2	genetic interference	Wong AS (2016)	1
MCM5	1	HIST2H2AA3	0	affinity chromatography technology	Drissi R (2015)	1
RNF168	0	HIST2H2AA3	0	affinity chromatography technology	Pinato S (2011)	1
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
OBSL1	9	HIST2H2AA3	0	affinity chromatography technology	Hanson D (2014)	1
IL33	2	HIST2H2AA3	0	pull down	Roussel L (2008)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HIST2H2AA3	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
EGFR	5	HIST2H2AA3	0	affinity chromatography technology	Yao Z (2017)	1
SUZ12	0	RNF2	1	affinity chromatography technology	Cao Q (2014)	1
SUZ12	0	HDAC1	4	affinity chromatography technology, biochemical	Cao Q (2014), Wan C (2015)	2
MCM2	3	UBC	7	affinity chromatography technology	Drissi R (2015)	1
PRMT6	2	HIST2H2AA3	0	enzymatic study	Cloutier P (2013)	1
MCM2	3	APP	1	pull down	Olah J (2011)	1
HIST2H2AA3	0	DNAJC2	0	affinity chromatography technology, pull down	Richly H (2010), Richly H (2010)	2
GEMIN5	1	HIST2H2AA3	0	affinity chromatography technology	Hein MY (2015)	1
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
CUL7	4	HIST2H2AA3	0	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	AURKB	2	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	PARP1	3	affinity chromatography technology	Hanson D (2014)	1
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
EGFR	5	PARP1	3	affinity chromatography technology, affinity chromatography technology	Liccardi G (2014), Yao Z (2017)	2
WWOX	3	HIST2H2AA3	0	affinity chromatography technology	Abu-Odeh M (2014)	1
DNAJC2	0	RNF2	1	imaging technique	Richly H (2010)	1
BAP1	4	HIST2H2AA3	0	enzymatic study	Mashtalir N (2014)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
MSL2	3	HIST2H2AA3	0	enzymatic study	Wu L (2011)	1
OBSL1	9	NOC2L	5	affinity chromatography technology	Hanson D (2014)	1
RNF20	9	MSL2	3	biochemical, biochemical	Wu L (2014), Wu L (2014)	2
PDHA1	7	HIST2H2AA3	0	affinity chromatography technology	Malty RH (2017)	1
UBC	7	PDHA1	7	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	HIST2H2AA3	0	pull down	Zhang X (2017)	1
RNF2	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014)	2
NOC2L	5	AURKB	2	affinity chromatography technology	Wu L (2011)	1
EGFR	5	MAPK8	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
RNF20	9	HIST2H2AA3	0	enzymatic study	Kim J (2011)	1
SRRM1	2	HIST2H2AA3	0	affinity chromatography technology	McCracken S (2005)	1
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
AURKB	2	APP	1	pull down	Olah J (2011)	1
TBL1X	1	HIST2H2AA3	0	pull down	Yoon HG (2003)	1
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
EGFR	5	SRRM1	2	affinity chromatography technology	Yao Z (2017)	1
RNF2	1	MCM5	1	affinity chromatography technology	Cao Q (2014)	1
WWOX	3	GEMIN5	1	affinity chromatography technology	Abu-Odeh M (2014)	1
OBSL1	9	PARP1	3	affinity chromatography technology	Hanson D (2014)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
APP	1	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1