PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PARP1	3	ATP5A1	0	affinity chromatography technology	Wu T (2013)	1
APC	5	XPO1	8	affinity chromatography technology, pull down	Tickenbrock L (2002), Tickenbrock L (2002)	2
RNF146	4	TNKS	12	pull down	DaRosa PA (2014)	1
RNF146	4	TUBB	3	affinity chromatography technology	Kang HC (2011)	1
CHD1L	5	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF146	4	HIST2H2AB	1	affinity chromatography technology	Huttlin EL (2015)	1
HIST1H1C	2	NCL	1	affinity chromatography technology, affinity chromatography technology, pull down	Kim K (2008), Kim K (2008), Kim K (2008)	3
NCL	1	XRCC6	3	pull down	Kobayashi J (2012)	1
XPC	1	CETN2	0	biochemical, pull down, affinity chromatography technology, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Araki M (2001), Araki M (2001), Bunick CG (2006), Havugimana PC (2012), Gupta GD (2015), Huttlin EL (2017), Lan X (2016)	7
HSPA5	0	HNRNPU	12	affinity chromatography technology, biochemical	Li J (2013), Wan C (2015)	2
TUBGCP4	3	HSPA5	0	affinity chromatography technology	Fogeron ML (2013)	1
PARP1	3	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Sand-Dejmek J (2011), Wu T (2013)	11
RNF146	4	SSRP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSPA9	2	XPO1	8	two hybrid	Wang J (2011)	1
RNF146	4	HSPA9	2	affinity chromatography technology	Kang HC (2011)	1
UBE2G2	0	RNF146	4	two hybrid	van Wijk SJ (2009)	1
PARP1	3	TUBB	3	affinity chromatography technology	Wu T (2013)	1
CHD1L	5	SSRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
7515	0	XPO1	8	affinity chromatography technology, affinity chromatography technology	Chase GP (2011), Chase GP (2011)	2
RNF146	4	CHD1L	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BLZF1	0	RNF146	4	affinity chromatography technology	Zhang Y (2011)	1
TUBGCP4	3	RNF146	4	two hybrid	Rolland T (2014)	1
PARP1	3	SUPT16H	4	enzymatic study	Huang JY (2006)	1
XRCC6	3	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF146	4	UBE2D2	0	enzymatic study	DaRosa PA (2014)	1
PARP1	3	7515	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gueven N (2004), Gueven N (2004), Masson M (1998), Masson M (1998), Cazzalini O (2010), Lee CH (2010), Leppard JB (2003)	7
XRCC5	5	NCL	1	biochemical	Kristensen AR (2012)	1
IPO5	0	IPO7	3	biochemical	Wan C (2015)	1
RNF146	4	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF146	4	PARP1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Kang HC (2011), Kang HC (2011), Kang HC (2011), Huttlin EL (2015), Huttlin EL (2017)	6
RNF146	4	HSPA5	0	affinity chromatography technology	Kang HC (2011)	1
AXIN2	1	APC	5	affinity chromatography technology	von Kries JP (2000)	1
XPC	1	PARP1	3	affinity chromatography technology	Huttlin EL (2017)	1
XRCC6	3	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF146	4	HIST1H1C	2	affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Kang HC (2011)	2
RNF146	4	NCL	1	affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Kang HC (2011)	2
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
HNRNPU	12	SUPT16H	4	affinity chromatography technology	Hein MY (2015)	1
RNF146	4	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Kang HC (2011)	2
XPC	1	HIST2H2AB	1	affinity chromatography technology	Huttlin EL (2017)	1
HSPA9	2	HNRNPU	12	biochemical	Wan C (2015)	1
TUBGCP4	3	TUBB	3	affinity chromatography technology	Fogeron ML (2013)	1
AXIN2	1	RNF146	4	affinity chromatography technology	Zhang Y (2011)	1
TUBGCP4	3	HNRNPU	12	affinity chromatography technology	Fogeron ML (2013)	1
LIG3	6	XRCC6	3	affinity chromatography technology, pull down, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Huttlin EL (2017)	3
CHD1L	5	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Huttlin EL (2017)	2
PTEN	24	RNF146	4	affinity chromatography technology, affinity chromatography technology	Li N (2015), Li N (2015)	2
RNF146	4	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHD1L	5	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009), Brockschmidt A (2011), Kulkarni A (2013), Huttlin EL (2017)	5
CHD1L	5	HLTF	7	affinity chromatography technology	Huttlin EL (2017)	1
PTEN	24	HNRNPU	12	affinity chromatography technology	Maddika S (2011)	1
XRCC6	3	SSRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
HSPA5	0	XRCC6	3	biochemical	Havugimana PC (2012)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
RNF146	4	UBE2D1	0	enzymatic study, x-ray crystallography	DaRosa PA (2014), DaRosa PA (2014)	2
LIG3	6	PARP1	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Leppard JB (2003), Leppard JB (2003)	4
XRCC6	3	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
XRCC6	3	7515	0	affinity chromatography technology	Huttlin EL (2017)	1
NCL	1	HNRNPU	12	affinity chromatography technology	Salvetti A (2016)	1
CHD1L	5	7515	0	affinity chromatography technology, affinity chromatography technology	Ahel D (2009), Huttlin EL (2017)	2
RNF146	4	IPO7	3	affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Kang HC (2011)	2
TUBGCP4	3	HSPA9	2	affinity chromatography technology	Fogeron ML (2013)	1
CHD1L	5	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009), Ahel D (2009), Kulkarni A (2013), Huttlin EL (2017)	5
XRCC5	5	SSRP1	1	affinity chromatography technology, imaging technique	Sand-Dejmek J (2011), Sand-Dejmek J (2011)	2
RNF146	4	HLTF	7	affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Huttlin EL (2015)	2
IPO5	0	XPO1	8	biochemical	Wan C (2015)	1
PARP1	3	CETN2	0	affinity chromatography technology	Wu T (2013)	1
RNF146	4	IPO5	0	affinity chromatography technology	Kang HC (2011)	1
7515	0	LIG3	6	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Whitehouse CJ (2001), Ewing RM (2007), Caldecott KW (1994), Nash RA (1997), Dulic A (2001), Taylor RM (1998), Ogi T (2010), Hein MY (2015)	8
XPC	1	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
CHD1L	5	TNKS	12	affinity chromatography technology	Huttlin EL (2017)	1
XRCC5	5	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Sand-Dejmek J (2011), Sand-Dejmek J (2011)	2
RNF146	4	XRCC6	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kang HC (2011), Kang HC (2011), Kang HC (2011)	3
TUBB	3	XPO1	8	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
PTEN	24	TUBB	3	pull down	Verrastro I (2015)	1
XPC	1	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	SSRP1	1	affinity chromatography technology	Kirli K (2015)	1
SSRP1	1	PARP1	3	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	SH3BP2	4	affinity chromatography technology	Kirli K (2015)	1
PARP1	3	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Wu T (2013), Huttlin EL (2017)	11
CHD1L	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009)	2
APC	5	RNF146	4	affinity chromatography technology	Tran H (2012)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
RNF146	4	7515	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kang HC (2011), Kang HC (2011), Kang HC (2011)	3
7515	0	PARP2	0	affinity chromatography technology, affinity chromatography technology	Schreiber V (2002), Schreiber V (2002)	2
SSRP1	1	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
SH3BP2	4	RNF146	4	affinity chromatography technology	Levaot N (2011)	1
PARP1	3	PARP2	0	affinity chromatography technology	Schreiber V (2002)	1
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
ATP5A1	0	HNRNPU	12	biochemical	Wan C (2015)	1
APC	5	TNKS	12	affinity chromatography technology	Tran H (2012)	1
SSRP1	1	HIST2H2AB	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	BLZF1	0	affinity chromatography technology	Kirli K (2015)	1
RNF146	4	PFN2	0	two hybrid	Stelzl U (2005)	1
RNF146	4	RNF146	4	enzymatic study, enzymatic study	Kang HC (2011), DaRosa PA (2014)	2
RNF146	4	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHD1L	5	PARP2	0	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Huttlin EL (2017)	2
TRAF2	1	RNF146	4	two hybrid	Rolland T (2014)	1
ATP5A1	0	HSPA5	0	biochemical	Havugimana PC (2012)	1
SH3BP2	4	TNKS	12	affinity chromatography technology	Levaot N (2011)	1
UBE2H	3	RNF146	4	two hybrid	Markson G (2009)	1
XPO1	8	TNKS	12	affinity chromatography technology	Kirli K (2015)	1
RNF146	4	CETN2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTEN	24	TNKS	12	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li N (2015), Li N (2015), Li N (2015)	3
APC	5	HSPA5	0	two hybrid	Bandyopadhyay S (2010)	1
XPO1	8	RNF146	4	affinity chromatography technology	Kirli K (2015)	1
PTEN	24	UBE2D1	0	genetic interference	Vizeacoumar FJ (2013)	1
BLZF1	0	TNKS	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2011), Huttlin EL (2015), Huttlin EL (2017)	3
RNF146	4	ATP5A1	0	affinity chromatography technology	Kang HC (2011)	1
RNF146	4	UBE2D3	1	pull down, enzymatic study, x-ray crystallography	Kang HC (2011), DaRosa PA (2014), DaRosa PA (2014)	3
RNF146	4	PARP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Huttlin EL (2015), Huttlin EL (2017)	3
RNF146	4	HNRNPU	12	affinity chromatography technology	Kang HC (2011)	1
PTEN	24	ATP5A1	0	pull down	Verrastro I (2015)	1
LIG3	6	XRCC5	5	affinity chromatography technology, pull down	Leppard JB (2003), Leppard JB (2003)	2
HIST1H1C	2	PARP1	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kim K (2008), Kim K (2008), Kim K (2008), Bonfiglio JJ (2017)	4
RNF146	4	CCDC155	2	two hybrid	Rolland T (2014)	1