PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MBD1	1	SP1	0	pull down	Schwarzenbach H (2014)	1
ATF7IP2	2	SETDB1	3	pull down, affinity chromatography technology	Ichimura T (2005), Ichimura T (2005)	2
MBD1	1	SETDB1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Lyst MJ (2006), Sarraf SA (2004), Sarraf SA (2004), Sarraf SA (2004)	4
EGFR	5	ATF7IP2	2	affinity chromatography technology	Yao Z (2017)	1
ATF7IP2	2	MBD1	1	pull down, pull down	Ichimura T (2005), Ichimura T (2005)	2
ATF7IP2	2	SP1	0	affinity chromatography technology, pull down	Ichimura T (2005), Ichimura T (2005)	2