PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MDM2	2	CCND1	1	affinity chromatography technology	Yang P (2016)	1
FAM98A	3	FBXO31	4	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	FBXO31	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	MRPS27	2	affinity chromatography technology	Bennett EJ (2010)	1
645455	0	FBXO31	4	affinity chromatography technology	Hein MY (2015)	1
CCND1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006), Wei S (2008), Yu ZK (1998)	4
COPS5	0	CDT1	2	biochemical	He YJ (2006)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
FBXO31	4	MRPS27	2	affinity chromatography technology	Hein MY (2015)	1
CDT1	2	CUL1	7	affinity chromatography technology	Li X (2003)	1
SNAI1	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim SO (2011), Lim SO (2010), Lim SO (2010)	3
COPS5	0	MRPS27	2	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
COPS5	0	MDM2	2	affinity chromatography technology, pull down	Zhang XC (2008), Zhang XC (2008)	2
FBXO31	4	CCNQ	0	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	FAM98A	3	affinity chromatography technology	Bennett EJ (2010)	1
RBX1	2	CCND1	1	affinity chromatography technology	Maeda I (2001)	1
FBXO31	4	SNAI1	1	affinity chromatography technology, affinity chromatography technology	Zou S (2018), Zou S (2018)	2
FBXO31	4	GHR	1	unspecified method	Bulatov E (2015)	1
STYX	1	FBXO31	4	affinity chromatography technology	Reiterer V (2017)	1
CUL1	7	FAM98A	3	affinity chromatography technology	Bennett EJ (2010)	1
CDT1	2	FBXO31	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Johansson P (2014), Johansson P (2014), Johansson P (2014), Johansson P (2014)	4
FBXO31	4	PDLIM1	1	affinity chromatography technology	Hein MY (2015)	1
FBXO31	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Kumar R (2005), Vadhvani M (2013), Jeffery JM (2017)	4
FBXO31	4	FOXM1	3	affinity chromatography technology	Jeffery JM (2017)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
FBXO31	4	STX3	3	affinity chromatography technology	Hein MY (2015)	1
CCND1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006)	2
CUL1	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inuzuka H (2010), Inuzuka H (2010), He Y (2014)	3
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
PRPS1	0	FBXO31	4	affinity chromatography technology	Hein MY (2015)	1
STYX	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
MYH6	12	FBXO31	4	affinity chromatography technology	Hein MY (2015)	1
FBXO31	4	MDM2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Malonia SK (2015), Malonia SK (2015), Malonia SK (2015)	3
MDM2	2	SNAI2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jung CH (2013), Lin TY (2016), Lin TY (2016)	3
MAP2K6	2	FBXO31	4	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
FBXO31	4	DNAJC19	2	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXO31	4	QSER1	7	affinity chromatography technology	Hein MY (2015)	1
MYH6	12	EDRF1	6	affinity chromatography technology	Hein MY (2015)	1
FBXO31	4	PARD6A	0	affinity chromatography technology, affinity chromatography technology	Vadhvani M (2013), Vadhvani M (2013)	2
FBXO31	4	RBX1	2	affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Jeffery JM (2017)	2
GHR	1	SKP1	0	affinity chromatography technology, unspecified method	da Silva Almeida AC (2013), Bulatov E (2015)	2
FBXO31	4	SNAI2	0	affinity chromatography technology, affinity chromatography technology	Manne RK (2017), Manne RK (2017)	2
FBXO31	4	CCND1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Santra MK (2009), Santra MK (2009), Santra MK (2009), Yumimoto K (2013), Johansson P (2014)	5
CUL1	7	GHR	1	unspecified method	Bulatov E (2015)	1
FBXO31	4	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Bennett EJ (2010), Vadhvani M (2013), Jeong YT (2013), Hein MY (2015), Malonia SK (2015), Jeffery JM (2017), Reitsma JM (2017)	8
FBXO31	4	EDRF1	6	affinity chromatography technology	Hein MY (2015)	1
STYX	1	CUL1	7	affinity chromatography technology	Li X (2016)	1
FBXO31	4	C18orf21	0	affinity chromatography technology	Hein MY (2015)	1
FBXO31	4	EFR3A	3	affinity chromatography technology	Hein MY (2015)	1
FBXO31	4	ZCCHC9	0	affinity chromatography technology	Hein MY (2015)	1
RBX1	2	GHR	1	unspecified method	Bulatov E (2015)	1
ZNF131	0	FBXO31	4	affinity chromatography technology	Varier RA (2016)	1
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1