PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IKBKB	1	PPP1R15A	2	affinity chromatography technology	Li HY (2008)	1
UBC	7	CUEDC2	0	pull down	Fenner BJ (2009)	1
CDC20	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kramer ER (1998), Kallio M (1998), Kallio M (1998), Nilsson J (2008), Jeganathan KB (2006), Nath S (2011), Lee YJ (2008), Lara-Gonzalez P (2011), Mansfeld J (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Lee YJ (2008), DAngiolella V (2003), Lee SJ (2012), Fang G (1998), Fang G (1998), Wolthuis R (2008), Ban KH (2007), Ge S (2009), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Kwan PS (2013), Sedgwick GG (2012), Eytan E (2013), Hyun SY (2013), Lim HJ (2013), Choi BH (2014), Fogeron ML (2013), Sackton KL (2014), Shoji S (2014), Han JS (2014), Lara-Gonzalez P (2011), Hein JB (2014), Vodermaier HC (2003), Yen AH (2010), Voets E (2015), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Craney A (2016), Listovsky T (2013), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	54
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
CUEDC2	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Gong L (2014), Gong L (2014)	2
PGR	1	CUEDC2	0	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Zhang PJ (2007), Zhang PJ (2007), Zhang PJ (2007), Zhang PJ (2007), Zhang PJ (2007)	5
CHUK	5	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Mitsuhashi S (2008), Mitsuhashi S (2008)	2
CUEDC2	0	PPP1CA	3	affinity chromatography technology	Li HY (2008)	1
CUEDC2	0	CDC27	2	affinity chromatography technology, affinity chromatography technology	Gao YF (2011), Zhang WN (2013)	2
GTF2A1	1	TBP	0	pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	DeJong J (1995), Langelier MF (2001), Ozer J (1998), Solow S (2001), Sun X (1994), Jeronimo C (2007), Maldonado E (1990), Mitsiou DJ (2003), Mitsiou DJ (2003), Huttlin EL (2015), Huttlin EL (2017), Gupta K (2017)	12
CUEDC2	0	CHUK	5	affinity chromatography technology, two hybrid	Li HY (2008), Li HY (2008)	2
CUEDC2	0	GTF2A1	1	affinity chromatography technology	Huttlin EL (2015)	1
EWSR1	2	GTF2A1	1	bioid	Elzi DJ (2014)	1
CUEDC2	0	CDC20	1	affinity chromatography technology, affinity chromatography technology	Gao YF (2011), Gao YF (2011)	2
PPP1CA	3	HSPA4	3	affinity chromatography technology	Flores-Delgado G (2007)	1
CDC20	1	UBC	7	enzymatic study, enzymatic study	Kelly A (2014), Craney A (2016)	2
MAPK3	4	CUEDC2	0	enzymatic study	Zhang WN (2013)	1
RNF26	2	CUEDC2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NAB2	2	CUEDC2	0	affinity chromatography technology	Huttlin EL (2017)	1
CUEDC2	0	FZR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang WN (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CHUK	5	ESR1	0	imaging technique	Park KJ (2005)	1
PPP1R15A	2	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Hung WJ (2003), Wu DY (2002), Colland F (2004)	3
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
EWSR1	2	CUEDC2	0	two hybrid, bioid	Rual JF (2005), Elzi DJ (2014)	2
CUEDC2	0	TBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IKBKB	1	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li HY (2008), Mitsuhashi S (2008), Mitsuhashi S (2008)	3
CUEDC2	0	ESR1	0	affinity chromatography technology, affinity chromatography technology	Pan X (2011), Pan X (2011)	2
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
ESR1	0	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nair SC (1996), Tateishi Y (2004), Suzuki T (2011), Azuma K (2004), Azuma K (2004), Nalvarte I (2010), Dhamad AE (2016)	7
CUEDC2	0	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Zhang WN (2012), Zhang WN (2012), Zhang WN (2012), Zhang WN (2012)	4
TBP	0	ESR1	0	pull down, pull down	Waernmark A (2001), Lazennec G (1997)	2
CDC20	1	MAD2L1	0	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, unspecified method, pull down, affinity chromatography technology	Zhang Y (2001), Sihn CR (2003), Luo X (2000), Sironi L (2001), DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kallio M (1998), Fang G (1998), Fang G (1998), Skoufias DA (2001), Nilsson J (2008), Privette LM (2008), Stegmeier F (2007), Ho CY (2010), Ho CY (2010), Mansfeld J (2011), Gao YF (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Townsend K (2009), Lee YJ (2008), DAngiolella V (2003), Tang Z (2001), Tang Z (2001), Sironi L (2001), Sironi L (2001), Ge S (2009), Mapelli M (2007), Tipton AR (2011), Mondal G (2006), Mondal G (2006), Westhorpe FG (2011), De Antoni A (2005), De Antoni A (2005), Kwan PS (2013), Katayama H (2012), Fava LL (2011), Santaguida S (2011), Mapelli M (2006), Eytan E (2013), Eytan E (2013), Hyun SY (2013), Han JS (2013), Rodriguez-Bravo V (2014), Fogeron ML (2013), Wang K (2014), Eytan E (2014), Hein JB (2014), Yen AH (2010), Yen AH (2010), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Lischetti T (2014), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Sedgwick GG (2016), Sedgwick GG (2016), Izawa D (2012), Izawa D (2012), Jia L (2016), Jia L (2016), Kaisari S (2017), Yang M (2008), Kim S (2010), Kim S (2010)	70
ESR1	0	PPP1CA	3	affinity chromatography technology, pull down	Tarallo R (2011), Nalvarte I (2010)	2
PGR	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Giulianelli S (2012), Giulianelli S (2012), Giulianelli S (2012)	3
PGR	1	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Vicent GP (2006), Vicent GP (2006)	2
CUEDC2	0	PPP1R15A	2	two hybrid, affinity chromatography technology	Li HY (2008), Li HY (2008)	2
ESR1	0	EWSR1	2	affinity chromatography technology	Tarallo R (2011)	1
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
CUEDC2	0	IKBKB	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Li HY (2008), Li HY (2008), Li HY (2008)	3
ESR1	0	MAPK1	1	pull down, enzymatic study	Metivier R (2002), Tremblay A (2001)	2
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
CUEDC2	0	MAD2L1	0	affinity chromatography technology	Gao YF (2011)	1
CUEDC2	0	KHK	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC27	2	MAD2L1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wassmann K (1998), Kallio M (1998), Li Y (1997), Li Y (1997), Lara-Gonzalez P (2011), Mansfeld J (2011), Visconti R (2010), Ma HT (2011), Sironi L (2001), Tipton AR (2011), Tipton AR (2011), Westhorpe FG (2011), Eytan E (2013), Lara-Gonzalez P (2011), Yen AH (2010), Hein MY (2015), Craney A (2016), Sedgwick GG (2016)	18
MAPK1	1	CUEDC2	0	enzymatic study	Zhang WN (2013)	1
MAPK3	4	NAB2	2	two hybrid	Corominas R (2014)	1