PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
C3	7	C5	4	pull down	Jokiranta TS (2001)	1
C5	4	C6	0	biochemical, pull down, pull down	DiScipio RG (1992), DiScipio RG (1992), Haefliger JA (1989)	3
CPB2	0	C5	4	enzymatic study	Campbell WD (2002)	1
C5	4	C7	1	pull down	DiScipio RG (1992)	1
C5AR1	0	C5	4	pull down	Chen Z (1998)	1
LMNA	2	C5	4	two hybrid	Dittmer TA (2014)	1
C5	4	C8B	1	pull down	Stewart JL (1987)	1
C5	4	CREB3L1	1	two hybrid	Rolland T (2014)	1