Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
C5 727 ECULIZUMAB CHEMBL1201828 inhibitor, antibody TTD, TEND, TdgClinicalTrial, DrugBank, ChemblInteractions 17139284, 17016423, 17989688, 20011245, 20378572, 11752352, 16990386, 17702897, 18784156, 19399743
C5 727 GLOBULIN, IMMUNE CHEMBL1201599 binder DrugBank 20441428, 17911465, 17351760
C5 727 PEXELIZUMAB CHEMBL2107979 inhibitor ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
C5 rs56040400 CT eculizumab efficacy not stated Genotype CT is associated with decreased response to eculizumab in people with paroxysmal nocturnal hemoglobinuria as compared to genotype CC. 24521109 1183848019