PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APOA1	0	C1QA	0	affinity chromatography technology	Zhou M (2004)	1
FN1	17	UBQLN1	1	two hybrid	Rolland T (2014)	1
C1QA	0	SGTA	1	two hybrid	Wang J (2011)	1
C1QA	0	PIAS2	2	two hybrid	Wang J (2011)	1
APOA1	0	FN1	17	affinity chromatography technology	Zhou M (2004)	1
C1QA	0	RAC1	7	affinity chromatography technology, affinity chromatography technology	Woolery AR (2014), Woolery AR (2014)	2
C1QA	0	UBQLN1	1	two hybrid	Wang J (2011)	1
HSPB2	1	C1QA	0	two hybrid	Grose JH (2015)	1
UBQLN2	0	UBQLN1	1	two hybrid, affinity chromatography technology	Ford DL (2006), Ford DL (2006)	2
FN1	17	CRP	0	pull down	Salonen EM (1984)	1
FN1	17	C1S	0	affinity chromatography technology	Moussavi-Harami SF (2013)	1
FN1	17	BAG6	2	affinity chromatography technology	Humphries JD (2009)	1
RAC1	7	BAG6	2	two hybrid	Vinayagam A (2011)	1
C1QA	0	715	0	affinity chromatography technology	Thiel S (2000)	1
C1QA	0	GNPNAT1	0	two hybrid	Wang J (2011)	1
HIPK3	5	C1QA	0	two hybrid	Colland F (2004)	1
UBQLN1	1	BAG6	2	affinity chromatography technology, affinity chromatography technology	Kurlawala Z (2017), Kurlawala Z (2017)	2
C1QA	0	FN1	17	pull down	Bing DH (1982)	1
PPP1CC	2	C1QA	0	two hybrid, two hybrid	Esteves SL (2012), Fardilha M (2011)	2
FN1	17	PPP1CA	3	affinity chromatography technology	Humphries JD (2009)	1
C1S	0	715	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thielens NM (1999), Thiel S (2000), Thiel S (2000), Huttlin EL (2017)	4
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
PPP1CA	3	C1QA	0	two hybrid	Esteves SL (2012)	1
C1QA	0	C1S	0	affinity chromatography technology	Thiel S (2000)	1
SGTA	1	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, pull down	Winnefeld M (2006), Xu Y (2012), Xu Y (2012), Xu Y (2012), Leznicki P (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Darby JF (2014), Darby JF (2014), Darby JF (2014), Liu Y (2014), Krysztofinska EM (2016), Krysztofinska EM (2016)	14
BAG6	2	C1QA	0	two hybrid	Wang J (2011)	1
FN1	17	RAC1	7	affinity chromatography technology	Humphries JD (2009)	1
C1QA	0	UBQLN2	0	two hybrid	Wang J (2011)	1
CRP	0	C1QA	0	pull down	Jarva H (1999)	1
NLGN3	3	C1QA	0	two hybrid	Shen C (2015)	1
SLC25A47	3	C1QA	0	two hybrid	Wang J (2011)	1
C1QA	0	DCN	0	pull down	Krumdieck R (1992)	1