PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TLR2	0	ITPRIP	2	affinity chromatography technology	Huttlin EL (2017)	1
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
TLR2	0	TMEM214	2	affinity chromatography technology	Huttlin EL (2017)	1
TLR2	0	CLEC4M	0	affinity chromatography technology	Ohtani M (2012)	1
TLR2	0	STK11IP	3	affinity chromatography technology	Huttlin EL (2017)	1
TLR2	0	TLR2	0	affinity chromatography technology	Yang RB (1999)	1
TLR1	3	TLR2	0	affinity chromatography technology, affinity chromatography technology	Takeuchi O (2002), Takeuchi O (2002)	2
CREBBP	29	TLR2	0	affinity chromatography technology	Melroe GT (2007)	1
TLR2	0	AP1M1	3	affinity chromatography technology	Huttlin EL (2017)	1
TLR2	0	USP33	1	affinity chromatography technology	Huttlin EL (2017)	1
TOLLIP	3	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Brissoni B (2006), Li S (2011), Lee JY (2009), Yagasaki Y (2004), Neumann D (2007), Ohnuma K (2005), Ohnuma K (2005), Jensen LE (2001), Rao N (2005), Lee HJ (2012), Lei L (2016)	12
EGFR	5	IRAK1	1	affinity chromatography technology	Yao Z (2017)	1
IRF3	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kim T (1999), Li S (2011), Weaver BK (1998), Lin R (1998), Bibeau-Poirier A (2006), Lin R (1999), Johnson J (2007), Marson A (2004), Aksoy E (2007), Devaraj SG (2007), Devaraj SG (2007), Melroe GT (2007), Melroe GT (2007), Suhara W (2002), Wathelet MG (1998), Qin BY (2005), Qin BY (2005), Lin R (2001), Lubyova B (2004), Jennings S (2005), Sarkar SN (2004), Kim H (2010), Yang H (2002), Xing J (2013), Chen Y (2015)	25
TLR2	0	ACVR2A	0	affinity chromatography technology	Huttlin EL (2017)	1
IRF3	4	TLR2	0	affinity chromatography technology	Melroe GT (2007)	1
TIRAP	1	MYD88	1	genetic interference, two hybrid, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, affinity chromatography technology	Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Ulrichts P (2010), Ulrichts P (2010)	10
EGFR	5	STAT5A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, enzymatic study, imaging technique	Schulze WX (2006), Schulze WX (2006), Olayioye MA (1999), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Fan QW (2013), Latha K (2013)	8
TIRAP	1	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TLR2	0	LGR4	3	affinity chromatography technology	Huttlin EL (2017)	1
TLR1	3	TMEM214	2	affinity chromatography technology	Huttlin EL (2017)	1
MYD88	1	TLR2	0	two hybrid	Chuang TH (2004)	1
TLR2	0	LY96	0	affinity chromatography technology	Dziarski R (2001)	1
TLR2	0	STAT5A	4	affinity chromatography technology	Huttlin EL (2017)	1
TLR2	0	IRAK1	1	affinity chromatography technology	Yang RB (1999)	1
TLR2	0	CLEC7A	3	affinity chromatography technology	Ohtani M (2012)	1
TLR2	0	TOLLIP	3	affinity chromatography technology, pull down	Zhang G (2002), Zhang G (2002)	2
TLR2	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	AP1M1	3	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
CD14	3	TLR2	0	affinity chromatography technology	Yang RB (1999)	1
TLR2	0	TIRAP	1	protein complementation assay, protein complementation assay	Ulrichts P (2007), Ulrichts P (2008)	2
ATG16L1	1	TLR2	0	affinity chromatography technology	Boada-Romero E (2013)	1
EGFR	5	TLR2	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2