PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SLC6A3	6	TUBA1B	0	affinity chromatography technology, affinity chromatography technology	Wersinger C (2005), Wersinger C (2005)	2
SLC6A3	6	TGFB1I1	2	two hybrid, pull down	Carneiro AM (2002), Carneiro AM (2002)	2
SLC6A3	6	EPS15	1	affinity chromatography technology	Sorkina T (2006)	1
SLC6A3	6	TUBB1	1	affinity chromatography technology, affinity chromatography technology	Wersinger C (2005), Wersinger C (2005)	2
PRKN	1	EPS15	1	pull down, enzymatic study	Fallon L (2006), Fallon L (2006)	2
SNCA	0	SLC6A3	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wersinger C (2003), Wersinger C (2003), Lee FJ (2001), Lee FJ (2001), Wersinger C (2003), Wersinger C (2003), Wersinger C (2004), Wersinger C (2004), Wersinger C (2005), Wersinger C (2005)	10
PRKN	1	CAMK2A	6	affinity chromatography technology	Fallon L (2002)	1
SNCA	0	TUBB1	1	affinity chromatography technology, affinity chromatography technology	Wersinger C (2005), Wersinger C (2005)	2
PRKN	1	SLC6A3	6	affinity chromatography technology	Jiang H (2004)	1
PRKN	1	PICK1	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Joch M (2007), Joch M (2007), Joch M (2007), Joch M (2007)	4
SLC6A3	6	PICK1	2	two hybrid, affinity chromatography technology	Torres GE (2001), Torres GE (2001)	2
MTNR1A	1	EPS15	1	two hybrid	Benleulmi-Chaachoua A (2016)	1
SNCA	0	TUBA1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Alim MA (2002), Alim MA (2002), Alim MA (2002), Woods WS (2007), Wersinger C (2005), Wersinger C (2005)	6
SLC6A3	6	NEDD4	2	affinity chromatography technology, enzymatic study	Sorkina T (2006), Vina-Vilaseca A (2010)	2
NEDD4	2	EPS15	1	enzymatic study	Woelk T (2006)	1
PRKN	1	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology	Choi P (2001), Choi P (2001), Kawahara K (2008), Hampe C (2006), Nemes Z (2009), Oluwatosin-Chigbu Y (2003), Yang Y (2003), Norris KL (2015)	8
STX1A	2	SLC6A3	6	pull down, affinity chromatography technology, affinity chromatography technology	Binda F (2008), Binda F (2008), Cartier E (2015)	3
MTNR1A	1	SLC6A3	6	two hybrid	Benleulmi-Chaachoua A (2016)	1
CAMK2A	6	SLC6A3	6	affinity chromatography technology	Sakrikar D (2012)	1
SLC6A3	6	EPN1	4	affinity chromatography technology	Sorkina T (2006)	1
SNTA1	1	SLC6A3	6	unspecified method	Boisguerin P (2004)	1
PRKN	1	TUBB1	1	affinity chromatography technology	Zanon A (2013)	1
NEDD4	2	SNCA	0	enzymatic study, affinity chromatography technology, enzymatic study	Tofaris GK (2011), Tofaris GK (2011), Sugeno N (2014)	3
TUBA1B	0	TUBB1	1	affinity chromatography technology, affinity chromatography technology	Wersinger C (2005), Wersinger C (2005)	2
EPN1	4	EPS15	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology	Chen H (1998), Chen H (1998), Hoeller D (2006), Ko G (2010), Sugiyama S (2005), Huang JH (2008)	6