PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EHMT2	4	CBX3	1	pull down, imaging technique, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Chin HG (2007), Chin HG (2007), Ruan J (2012), Ruan J (2012), Roopra A (2004), Hauri S (2016)	6
EHMT2	4	AIFM1	1	affinity chromatography technology	Hauri S (2016)	1
HNRNPL	3	EHMT1	18	affinity chromatography technology	Fei T (2017)	1
RUVBL2	4	TRIM28	1	affinity chromatography technology	Jeronimo C (2007)	1
CBX3	1	ZNF644	6	affinity chromatography technology	Hauri S (2016)	1
SOX2	4	ZNF462	11	affinity chromatography technology	Cox JL (2013)	1
ANKRA2	0	TRIM28	1	affinity chromatography technology	Nie J (2015)	1
HNRNPL	3	ZNF462	11	affinity chromatography technology	Fei T (2017)	1
EHMT2	4	RCN2	0	affinity chromatography technology	Hauri S (2016)	1
CBX1	0	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Chang CW (2008), Chang CW (2008), Ryan RF (1999), Rosnoblet C (2011), Moriyama T (2015), Huttlin EL (2017), Hauri S (2016)	8
EHMT2	4	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hauri S (2016)	2
TFAP4	3	EHMT2	4	affinity chromatography technology	Ku WC (2009)	1
CBX1	0	SCGB2A1	0	affinity chromatography technology	Hauri S (2016)	1
EHMT2	4	WIZ	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ueda J (2006), Ueda J (2006), Bantscheff M (2011), Hein MY (2015), Hauri S (2016)	5
CBX3	1	ZNF462	11	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
CBX1	0	ZNF462	11	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
EHMT2	4	CBX1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Spektor TM (2009), Chin HG (2007), Roopra A (2004), Hauri S (2016)	4
TFAP4	3	ZNF462	11	affinity chromatography technology	Ku WC (2009)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
ZNF462	11	RUVBL2	4	affinity chromatography technology	Hauri S (2016)	1
ZNF462	11	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
ZNF462	11	KLHL21	3	affinity chromatography technology	Hauri S (2016)	1
ZNF462	11	TRIM28	1	affinity chromatography technology	Hauri S (2016)	1
CBX5	3	TRIM28	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2002), Cammas F (2002), Cammas F (2002), Nielsen AL (2001), Lechner MS (2000), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Ryan RF (1999), Rosnoblet C (2011), Hu C (2012), Hu C (2012), White D (2012), Nozawa RS (2010), Kubota S (2013), Kubota S (2013), Kubota S (2013), Garvin AJ (2013), Huttlin EL (2017), Hauri S (2016)	21
CBX5	3	WIZ	2	affinity chromatography technology	Nozawa RS (2010)	1
ZNF462	11	D2HGDH	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
CBX1	0	EHMT1	18	affinity chromatography technology	Hauri S (2016)	1
CBX3	1	TRIM28	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Bandyopadhyay S (2010), Ryan RF (1999), Higo S (2010), Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	7
ZNF462	11	AIFM1	1	affinity chromatography technology	Hauri S (2016)	1
ZNF462	11	CALU	4	affinity chromatography technology	Hauri S (2016)	1
ZNF644	6	EHMT2	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hauri S (2016)	2
HNRNPL	3	TFAP4	3	affinity chromatography technology	Fei T (2017)	1
SOX2	4	ZNF644	6	affinity chromatography technology	Cox JL (2013)	1
CBX3	1	SCGB2A1	0	affinity chromatography technology	Hauri S (2016)	1
WIZ	2	EHMT1	18	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
CBX5	3	EHMT1	18	affinity chromatography technology	Nozawa RS (2010)	1
CBX5	3	ZNF462	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	4
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
ZNF644	6	EHMT1	18	affinity chromatography technology	Hein MY (2015)	1
CBX5	3	SCGB2A1	0	affinity chromatography technology	Hauri S (2016)	1
FBXO7	1	AIFM1	1	affinity chromatography technology	Teixeira FR (2016)	1
FBXO7	1	ZNF462	11	enzymatic study	Teixeira FR (2016)	1
EHMT2	4	CBX5	3	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Chin HG (2007), Chin HG (2007), Nozawa RS (2010), Roopra A (2004)	4
RUVBL2	4	EHMT2	4	affinity chromatography technology, affinity chromatography technology, pull down	Lee JS (2010), Lee JS (2010), Lee JS (2010)	3
SOX2	4	EHMT2	4	affinity chromatography technology	Cox JL (2013)	1
CBX3	1	WIZ	2	affinity chromatography technology	Hauri S (2016)	1
CBX3	1	RCN2	0	affinity chromatography technology	Hauri S (2016)	1
FBXO7	1	RUVBL2	4	affinity chromatography technology	Teixeira FR (2016)	1
EHMT2	4	TRIM28	1	affinity chromatography technology	Hauri S (2016)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
ZNF462	11	ZNF644	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
CBX1	0	WIZ	2	affinity chromatography technology	Hauri S (2016)	1
ZNF462	11	WIZ	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
CBX3	1	EHMT1	18	affinity chromatography technology	Hauri S (2016)	1
ANKRA2	0	ZNF462	11	affinity chromatography technology	Nie J (2015)	1
CBX1	0	ZNF644	6	affinity chromatography technology	Hauri S (2016)	1
SOX2	4	RUVBL2	4	affinity chromatography technology	Engelen E (2011)	1
TFAP4	3	WIZ	2	affinity chromatography technology	Ku WC (2009)	1
ZNF462	11	SCGB2A1	0	affinity chromatography technology	Hauri S (2016)	1
ZNF644	6	WIZ	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
ZNF462	11	RCN2	0	affinity chromatography technology	Hauri S (2016)	1
TFAP4	3	EHMT1	18	affinity chromatography technology	Ku WC (2009)	1
HYPK	2	ZNF462	11	affinity chromatography technology	Choudhury KR (2012)	1
ZNF462	11	DNAJB11	3	affinity chromatography technology	Hauri S (2016)	1
CBX5	3	RCN2	0	affinity chromatography technology	Hauri S (2016)	1
ZNF462	11	EHMT2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
TRIM28	1	HYPK	2	biochemical	Wan C (2015)	1