PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKN	1	UBE2N	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Joch M (2007), Olzmann JA (2007), Chaugule VK (2011), Sha D (2010), Lim GG (2013), Durcan TM (2011), McKeon JE (2014), Sha D (2010)	8
PRKN	1	UBE2D1	0	pull down	Kazlauskaite A (2014)	1
MARCH5	0	DNM1L	3	affinity chromatography technology, affinity chromatography technology	Yonashiro R (2006), Nakamura N (2006)	2
UNK	3	DNM1L	3	affinity chromatography technology	Murn J (2015)	1
MARCH5	0	UBE2D2	0	pull down, pull down, pull down	Yonashiro R (2012), Yonashiro R (2009), Sugiura A (2013)	3
MARCH5	0	UBE2E3	0	pull down	Nakamura N (2006)	1
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
MARCH5	0	MIA3	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CREB3	1	FIS1	0	two hybrid	Yu H (2011)	1
PRKN	1	FIS1	0	affinity chromatography technology	Sarraf SA (2013)	1
UBE2N	1	MFN2	5	affinity chromatography technology	Lim GG (2013)	1
TRAF6	0	MARCH5	0	affinity chromatography technology	Shi HX (2011)	1
CREB3	1	MARCH5	0	two hybrid	Yu H (2011)	1
PRKN	1	UBE2T	0	pull down	Kazlauskaite A (2014)	1
GRAMD2B	3	MARCH5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
PRKN	1	MFN2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glauser L (2011), Sun Y (2012), Sarraf SA (2013), Wang Y (2015)	4
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
MAVS	1	MFN2	5	affinity chromatography technology	Onoguchi K (2010)	1
PRKN	1	DNM1L	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang H (2011), Wang H (2011), Wang H (2011), Wang H (2011)	4
LAMP3	1	MARCH5	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2N	1	MARCH5	0	two hybrid	Markson G (2009)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBE2D1	0	UNK	3	biochemical	Havugimana PC (2012)	1
MFN1	6	CCNB1	3	affinity chromatography technology, affinity chromatography technology	Park YY (2012), Park YY (2012)	2
UNK	3	MARCH5	0	affinity chromatography technology	Murn J (2015)	1
UBE2W	0	MARCH5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
MARCH5	0	MARCH5	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yonashiro R (2006), Kim SH (2016), Chen Z (2017)	3
UBE2D2	0	CCNB1	3	enzymatic study	Tang Z (2001)	1
MARCH5	0	UBE2D1	0	pull down	Yonashiro R (2009)	1
TANK	1	MARCH5	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Shi HX (2011), Shi HX (2011), Shi HX (2011)	3
AKTIP	3	MARCH5	0	two hybrid	Markson G (2009)	1
MARCH5	0	FUNDC1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Chen Z (2017), Chen Z (2017), Chen Z (2017), Chen Z (2017)	4
SOD1	0	MARCH5	0	affinity chromatography technology, enzymatic study	Yonashiro R (2009), Yonashiro R (2009)	2
SOD1	0	MAVS	1	affinity chromatography technology	Huttlin EL (2017)	1
SOD1	0	DNM1L	3	affinity chromatography technology	Malty RH (2017)	1
MARCH5	0	MFN1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park YY (2010), Park YY (2012), Park YY (2014), Park YY (2014)	4
PRKN	1	MAVS	1	affinity chromatography technology, affinity chromatography technology	Khan M (2016), Khan M (2016)	2
PRKN	1	UBE2E1	1	pull down, pull down	Shin JH (2011), Kazlauskaite A (2014)	2
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
MARCH5	0	CCNB1	3	affinity chromatography technology	Park YY (2012)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
MARCH5	0	FIS1	0	affinity chromatography technology	Yonashiro R (2006)	1
MAVS	1	MARCH5	0	affinity chromatography technology	Shi HX (2011)	1
PRKN	1	UBE2E3	0	pull down	Kazlauskaite A (2014)	1
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
PRKN	1	CCNB1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee SB (2015), Lee SB (2015), Lee SB (2015)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2T	0	MARCH5	0	two hybrid	Markson G (2009)	1
PRKN	1	MFN1	6	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Glauser L (2011), Glauser L (2011), Sun Y (2012), Sarraf SA (2013), Kane LA (2014)	5
MFN2	5	MARCH5	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sugiura A (2013), Sugiura A (2013), Sugiura A (2013), Nakamura N (2006), Huttlin EL (2015), Kim HJ (2015), Huttlin EL (2017)	7
MARCH5	0	MAP1B	5	affinity chromatography technology, affinity chromatography technology, genetic interference, enzymatic study	Yonashiro R (2012), Yonashiro R (2012), Yonashiro R (2012), Yonashiro R (2012)	4
PRKN	1	ATXN3	2	pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography	Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Bai JJ (2013)	7
FIS1	0	DNM1L	3	affinity chromatography technology, affinity chromatography technology, pull down	Yoon Y (2003), Yoon Y (2003), Yoon Y (2003)	3
MFN1	6	SLC25A38	1	affinity chromatography technology, affinity chromatography technology	Zhang C (2016), Zhang C (2016)	2
MARCH5	0	UBE2E1	1	pull down	Nakamura N (2006)	1
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
MARCH5	0	SLC25A38	1	affinity chromatography technology, affinity chromatography technology	Zhang C (2016), Zhang C (2016)	2
SOD1	0	UBE2N	1	affinity chromatography technology	Malty RH (2017)	1
ATXN3	2	MARCH5	0	affinity chromatography technology	Kristensen LV (2018)	1
ATXN3	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
ATXN3	2	DNM1L	3	affinity chromatography technology	Kristensen LV (2018)	1
KIAA0368	0	MARCH5	0	affinity chromatography technology	Gorbea C (2010)	1
MARCH5	0	UBE2D3	1	pull down	Yonashiro R (2009)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
MARCH5	0	FATE1	0	two hybrid	Rolland T (2014)	1
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
PRKN	1	MARCH5	0	affinity chromatography technology	Sarraf SA (2013)	1
MFN1	6	MFN2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Mukherjee R (2016)	2
UBE2I	0	MARCH5	0	two hybrid	Markson G (2009)	1
SLC25A26	1	MARCH5	0	affinity chromatography technology, affinity chromatography technology	Zhang C (2016), Zhang C (2016)	2
MAVS	1	MFN1	6	affinity chromatography technology	Onoguchi K (2010)	1
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
MFN2	5	SLC25A38	1	affinity chromatography technology, affinity chromatography technology	Zhang C (2016), Zhang C (2016)	2