PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPD	3	UBE2I	0	two hybrid, pull down	Moraes KC (2003), Moraes KC (2003)	2
HDAC1	4	PEX10	0	affinity chromatography technology	Hein MY (2015)	1
PHKG2	2	PEX10	0	affinity chromatography technology	Hein MY (2015)	1
PEX12	2	PEX5	2	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Chang CC (1999), Okumoto K (2000), Okumoto K (2000), Chang CC (1999), Harper CC (2003), Fransen M (2002), Okumoto K (2011)	7
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
PEX5	2	PEX2	2	affinity chromatography technology	Okumoto K (2011)	1
PEX5	2	MKRN3	2	two hybrid	Rolland T (2014)	1
PEX14	2	PEX2	2	biochemical	Bharti P (2011)	1
TRIM25	5	PCGF6	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PEX10	0	affinity chromatography technology	Choudhury NR (2017)	1
PEX14	2	PEX10	0	biochemical	Bharti P (2011)	1
PEX12	2	PEX10	0	two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Chang CC (1999), Okumoto K (2000), Okumoto K (2000), Okumoto K (2000), Okumoto K (2000), Chang CC (1999), Fransen M (2002), Fransen M (2002)	8
PEX19	2	PEX14	2	pull down, two hybrid, two hybrid, biochemical, biochemical	Sacksteder KA (2000), Fransen M (2002), Fransen M (2002), Bharti P (2011), Bharti P (2011)	5
HNRNPD	3	PEX10	0	two hybrid	Lehner B (2004)	1
SCN3B	0	PEX10	0	affinity chromatography technology	Huttlin EL (2017)	1
PEX19	2	PEX12	2	two hybrid, pull down, two hybrid, two hybrid	Sacksteder KA (2000), Sacksteder KA (2000), Fransen M (2001), Fransen M (2002)	4
PEX2	2	PEX10	0	pull down	Okumoto K (2000)	1
PEX10	0	PEX5	2	pull down, affinity chromatography technology	Okumoto K (2000), Okumoto K (2011)	2
PEX10	0	PEX10	0	pull down, two hybrid	Okumoto K (2000), Woodsmith J (2012)	2
PEX14	2	PEX12	2	biochemical	Bharti P (2011)	1
UBE2I	0	PEX10	0	two hybrid	Markson G (2009)	1
HNRNPD	3	HDAC1	4	affinity chromatography technology, pull down	Lee C (2008), Lee C (2008)	2
TRIM25	5	HNRNPD	3	affinity chromatography technology	Choudhury NR (2017)	1
CLCN2	3	PEX10	0	affinity chromatography technology	Hein MY (2015)	1
PEX19	2	PEX10	0	two hybrid, two hybrid, two hybrid	Sacksteder KA (2000), Fransen M (2001), Fransen M (2002)	3
UBE2I	0	MKRN3	2	two hybrid	Markson G (2009)	1
PEX14	2	PEX5	2	two hybrid, pull down, pull down, pull down, pull down, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical	Okumoto K (2000), Okumoto K (2000), Otera H (2002), Otera H (2002), Shimizu N (1999), Fransen M (2002), Fransen M (2002), Fransen M (2002), Will GK (1999), Will GK (1999), Will GK (1999), Okumoto K (2011), Bharti P (2011), Bharti P (2011)	14
PCGF6	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2017), Hauri S (2016)	3
PCGF6	0	PEX10	0	two hybrid	Woodsmith J (2012)	1
CGRRF1	0	PEX10	0	two hybrid	Woodsmith J (2012)	1
MKRN3	2	PEX10	0	two hybrid	Woodsmith J (2012)	1
LIG4	0	PEX10	0	two hybrid	Woods NT (2012)	1