PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D2	0	LRSAM1	2	two hybrid	Markson G (2009)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
UBE2D4	0	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
UBE2W	0	TRIM17	5	two hybrid	Markson G (2009)	1
UBE2D4	0	TRAF6	0	two hybrid	Markson G (2009)	1
HSP90AA1	7	UBE2N	1	pull down	Zhang M (2005)	1
UBE2D4	0	LRSAM1	2	two hybrid	Markson G (2009)	1
HSP90AA1	7	TRIM41	6	affinity chromatography technology	Taipale M (2012)	1
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
UBE2D1	0	LRSAM1	2	two hybrid, pull down, enzymatic study	Markson G (2009), Chua HH (2016), Hakonen JE (2017)	3
UBE2E1	1	LRSAM1	2	two hybrid	Markson G (2009)	1
HSP90AA1	7	LRSAM1	2	affinity chromatography technology	Taipale M (2012)	1
TRIM17	5	LRSAM1	2	two hybrid	Woodsmith J (2012)	1
UBE2E1	1	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
UBE2D1	0	TRIM39	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Huang NJ (2012), Woodsmith J (2012), Rolland T (2014), Yu H (2011)	6
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBE2D3	1	LRSAM1	2	two hybrid	Markson G (2009)	1
HSP90AA1	7	TRIM17	5	affinity chromatography technology	Taipale M (2012)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2D3	1	TRIM17	5	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
UBE2W	0	LRSAM1	2	two hybrid	Markson G (2009)	1
UBE2H	3	TRIM17	5	two hybrid	Markson G (2009)	1
UBE2D2	0	TRIM17	5	two hybrid, two hybrid, pull down	Markson G (2009), Napolitano LM (2011), Woodsmith J (2012)	3
ZWINT	1	TRIM17	5	affinity chromatography technology, affinity chromatography technology	Endo H (2011), Endo H (2011)	2
TRIM17	5	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
UBE2D2	0	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
LGALS8	4	TRIM17	5	pull down	Chauhan S (2016)	1
TRIM17	5	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Woodsmith J (2012), Rolland T (2014)	3
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
TRIM17	5	SNX2	4	affinity chromatography technology	Huttlin EL (2017)	1
LGALS3	0	TRIM17	5	pull down	Chauhan S (2016)	1
TRIM17	5	TRIM44	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Urano T (2009), Urano T (2009), Urano T (2009), Huttlin EL (2017)	4
UBE2D4	0	TRIM17	5	two hybrid	Markson G (2009)	1
MNAT1	0	TRIM17	5	two hybrid	Woodsmith J (2012)	1
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
UBE2D1	0	TRIM17	5	two hybrid, two hybrid, pull down	Markson G (2009), Napolitano LM (2011), Woodsmith J (2012)	3
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
TRIM39	0	UBE2N	1	pull down	Woodsmith J (2012)	1
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
TRIM17	5	UBE2N	1	pull down	Woodsmith J (2012)	1
UBE2H	3	LRSAM1	2	two hybrid	Markson G (2009)	1
UBE2N	1	LRSAM1	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Hakonen JE (2017)	3
TRIM41	6	UBE2D2	0	pull down	Chen D (2007)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
TRIM17	5	TRIM41	6	two hybrid	Woodsmith J (2012)	1
TRIM17	5	TRAF6	0	two hybrid	Woodsmith J (2012)	1
MNAT1	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
USP15	4	TRIM17	5	two hybrid	Hayes SD (2012)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBE2W	0	TRIM39	0	two hybrid	Markson G (2009)	1
TRIM17	5	UBC	7	enzymatic study	Woodsmith J (2012)	1