PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PCBD1	0	EHMT1	18	two hybrid	Ravasi T (2010)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
PCBD1	0	PCBD1	0	two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid	Rual JF (2005), Rual JF (2005), Rho H (2010), Rolland T (2014), Yu H (2011)	5
PCBD1	0	GORASP2	1	two hybrid	Rual JF (2005)	1
PCBD1	0	RBL2	5	two hybrid	Ravasi T (2010)	1
COPS5	0	RPS24	1	affinity chromatography technology	Bennett EJ (2010)	1
DVL2	5	ZNF263	2	two hybrid	Rual JF (2005)	1
MYC	2	CUL1	7	affinity chromatography technology	von der Lehr N (2003)	1
MYC	2	PCBD1	0	genetic interference	Toyoshima M (2012)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
FXR2	2	NIF3L1	0	two hybrid	Rolland T (2014)	1
UAP1L1	1	PCBD1	0	biochemical	Wan C (2015)	1
NFKB1	2	PCBD1	0	two hybrid	Ravasi T (2010)	1
HES4	0	PCBD2	0	two hybrid	Ravasi T (2010)	1
POLR3A	4	GTF3C3	2	biochemical	Wan C (2015)	1
CUL4B	8	NFKB1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
SMARCD1	5	BRD7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Huttlin EL (2015), Huttlin EL (2017)	3
PCBD1	0	WWP1	3	two hybrid	Ravasi T (2010)	1
PCBD1	0	PCBD2	0	two hybrid	Ravasi T (2010)	1
PCBD1	0	ZNF567	1	two hybrid	Ravasi T (2010)	1
CUL3	17	NFKB1	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK5RAP2	3	PCBD1	0	two hybrid	Wang J (2011)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
PCBD1	0	ZNF195	0	two hybrid	Ravasi T (2010)	1
GTF3C3	2	BRD7	2	biochemical	Wan C (2015)	1
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
PCBD1	0	CEBPZ	4	two hybrid	Ravasi T (2010)	1
PAH	1	PCBD1	0	two hybrid	Waters PJ (2001)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
PCBD1	0	DYRK1B	1	two hybrid, affinity chromatography technology	Lim S (2002), Lim S (2002)	2
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
PCBD1	0	ZNF23	3	two hybrid	Ravasi T (2010)	1
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
CUL4A	2	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
MYC	2	GTF3C3	2	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Koch HB (2007)	2
PCBD1	0	KLF13	3	two hybrid	Ravasi T (2010)	1
UAP1L1	1	AFMID	1	biochemical	Wan C (2015)	1
PCBD1	0	POLR3A	4	two hybrid	Ravasi T (2010)	1
CUL3	17	WDR1	3	affinity chromatography technology	Wimuttisuk W (2014)	1
CUL3	17	SUPT5H	2	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	BRD7	2	two hybrid	Ravasi T (2010)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
HNF1A	0	PCBD2	0	affinity chromatography technology	Ewing RM (2007)	1
LNX1	7	WWP1	3	two hybrid	Wolting CD (2011)	1
ADSS	1	WDR1	3	biochemical	Kristensen AR (2012)	1
PCBD1	0	WDYHV1	0	two hybrid	Rual JF (2005)	1
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
CUL3	17	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
DVL2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Mund T (2015), Mund T (2015), Mund T (2015)	3
PCBD1	0	SCMH1	1	two hybrid	Ravasi T (2010)	1
APP	1	MYC	2	pull down	Virok DP (2011)	1
HNF1A	0	HNF1B	3	pull down, pull down	Mendel DB (1991), Lindner TH (1999)	2
GORASP2	1	CUL3	17	biochemical	Kristensen AR (2012)	1
PCBD1	0	HES4	0	two hybrid	Ravasi T (2010)	1
CUL4B	8	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	SAP30	1	two hybrid	Ravasi T (2010)	1
CUL3	17	ADSS	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	CACNA1C	8	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	ZNF714	1	two hybrid	Ravasi T (2010)	1
CUL4A	2	NFKB1	2	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	ACIN1	6	pull down	Miyamoto-Sato E (2010)	1
PCBD1	0	SMARCD1	5	two hybrid	Ravasi T (2010)	1
CUL4B	8	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016)	8
LNX1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PCBD1	0	NUDT18	0	two hybrid	Rual JF (2005)	1
ZNF23	3	APP	1	pull down	Olah J (2011)	1
CUL5	1	RPS24	1	affinity chromatography technology	Bennett EJ (2010)	1
ADSS	1	PCBD1	0	biochemical	Wan C (2015)	1
DCUN1D1	0	NFKB1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PCBD1	0	SOWAHC	2	two hybrid	Ravasi T (2010)	1
MYC	2	CUL4A	2	affinity chromatography technology	Choi SH (2010)	1
CUL3	17	DVL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin X (2016), Jin X (2016), Jin X (2016)	3
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	SUPT5H	2	two hybrid	Ravasi T (2010)	1
PCBD1	0	FXR2	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
PCBD1	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
PCBD1	0	GTF3C3	2	two hybrid	Ravasi T (2010)	1
PCBD1	0	DIP2C	12	two hybrid	Ravasi T (2010)	1
CACNA1C	8	COPS5	0	two hybrid	Kameda K (2006)	1
CUL5	1	NFKB1	2	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
FXR2	2	ZNF451	3	two hybrid	Rual JF (2005)	1
PCBD1	0	MIS18BP1	6	two hybrid	Ravasi T (2010)	1
CUL5	1	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	LNX1	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
HNF1A	0	PCBD1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid	Ewing RM (2007), Sourdive DJ (1997), Sourdive DJ (1997), Sourdive DJ (1997), Rho H (2010), Wang J (2011)	6
CALCOCO1	2	APP	1	pull down	Olah J (2011)	1
PCBD1	0	ZNF263	2	two hybrid	Ravasi T (2010)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	RPS24	1	affinity chromatography technology	Bennett EJ (2010)	1
DYRK1B	1	RBL2	5	affinity chromatography technology	Varjosalo M (2013)	1
CUL1	7	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	TRIM5	4	two hybrid	Ravasi T (2010)	1
AFMID	1	PCBD1	0	biochemical	Wan C (2015)	1
PCBD1	0	PAPOLG	3	two hybrid	Ravasi T (2010)	1
PCBD2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
PCBD1	0	ZNF202	1	two hybrid	Ravasi T (2010)	1
CUL3	17	RPS24	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	SAP30	1	affinity chromatography technology, affinity chromatography technology	Ji Q (2014), Ji Q (2014)	2
PCBD1	0	CALCOCO1	2	two hybrid	Ravasi T (2010)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
PCBD1	0	RPS24	1	pull down	Miyamoto-Sato E (2010)	1
CUL3	17	FXR2	2	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	ZNF451	3	two hybrid	Ravasi T (2010)	1
PCBD1	0	HNF1B	3	two hybrid	Ravasi T (2010)	1
PCBD1	0	ZBTB25	2	two hybrid	Ravasi T (2010)	1
CUL4B	8	RPS24	1	affinity chromatography technology	Bennett EJ (2010)	1
GORASP2	1	APP	1	pull down	Olah J (2011)	1
DCUN1D1	0	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	NFKB1	2	affinity chromatography technology, two hybrid	Bennett EJ (2010), Wang J (2011)	2
COPS5	0	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	CACNA1C	8	two hybrid	Waters PJ (2001)	1
RBL2	5	CUL1	7	affinity chromatography technology	Bhattacharya S (2003)	1
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
HNF4A	2	PCBD1	0	two hybrid	Ravasi T (2010)	1
HNF4A	2	COPS5	0	two hybrid	Albers M (2005)	1
CUL4B	8	APP	1	pull down	Olah J (2011)	1
PCBD1	0	NIF3L1	0	two hybrid	Rual JF (2005)	1
DVL2	5	PCBD1	0	two hybrid	Rual JF (2005)	1
PCBD1	0	TIMELESS	8	two hybrid	Ravasi T (2010)	1
PCBD1	0	DENND4A	8	two hybrid	Ravasi T (2010)	1
UAP1L1	1	WDR1	3	biochemical	Wan C (2015)	1
WDR1	3	PCBD1	0	biochemical	Wan C (2015)	1
CUL3	17	ACIN1	6	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	TFF3	0	two hybrid	Rolland T (2014)	1
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2
PAH	1	RPS24	1	two hybrid	Wang J (2011)	1