PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MEP1A	2	MEP1A	2	biochemical	Ishmael FT (2001)	1
MEP1A	2	NPY	0	enzymatic study	Bertenshaw GP (2001)	1
MEP1A	2	GNRH1	0	enzymatic study	Bertenshaw GP (2001)	1
MEP1A	2	FN1	17	enzymatic study	Kaushal GP (1994)	1
MEP1A	2	LAMA5	20	enzymatic study	Koehler D (2000)	1
MEP1A	2	PTH	0	enzymatic study	Bertenshaw GP (2001)	1
MEP1A	2	KNG1	1	enzymatic study	Bertenshaw GP (2001)	1
MEP1A	2	VIP	3	enzymatic study	Bertenshaw GP (2001)	1
FBXW7	2	MEP1A	2	genetic interference	Bailey ML (2015)	1
MEP1A	2	NTS	1	enzymatic study	Bertenshaw GP (2001)	1
SRRM2	18	MEP1A	2	affinity chromatography technology	McCracken S (2005)	1
MEP1A	2	LAMA1	15	enzymatic study	Koehler D (2000)	1