PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
INPP5D	2	LYN	2	affinity chromatography technology, pull down	Baran CP (2003), Baran CP (2003)	2
STAT1	1	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique	Deberry C (1997), Deberry C (1997), Deberry C (1997), Deberry C (1997), Chen TC (2014)	5
KIT	4	PIK3R1	6	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	De Sepulveda P (1999), van Dijk TB (2000), Serve H (1994), Zhu MJ (2007), Zhu MJ (2007), Yokouchi M (1997), Chen TC (2014)	7
LYN	2	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down	Liang X (2002), Linnekin D (1997), Linnekin D (1997)	3
DOK1	2	SRC	2	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
KIT	4	PIK3R2	3	two hybrid	De Sepulveda P (1999)	1
KIT	4	26095	0	two hybrid	Yao Z (2017)	1
PIK3R2	3	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Kuchay S (2013), Hein MY (2015)	3
BCR	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2000), Million RP (2004), Million RP (2004), Puil L (1994), Puil L (1994), Ma G (1997), Maru Y (1995), Maru Y (1995), Gaston I (2004), Gaston I (2004), Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	13
PIK3R1	6	PIK3CA	8	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017)	9
LYN	2	CSF1R	0	affinity chromatography technology	Li Y (1995)	1
PIK3R2	3	CRKL	1	far western blotting, affinity chromatography technology, affinity chromatography technology	Sattler M (1997), Sattler M (1997), Martelli MP (2001)	3
KIT	4	KITLG	1	affinity chromatography technology, pull down	Lev S (1992), Blechman JM (1993)	2
TEC	2	KIT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	van Dijk TB (2000), Tang B (1994), Tang B (1994), Tang B (1994)	4
SRC	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Burnham MR (1999), Song JJ (2010), Liu W (2010), Chen TC (2014)	4
CSF1R	0	KIT	4	affinity chromatography technology, enzymatic study	Tsujimura T (1999), Tsujimura T (1999)	2
LYN	2	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
GRB10	4	JAK2	1	affinity chromatography technology	Moutoussamy S (1998)	1
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
LYN	2	PTPN6	0	pull down	Yoshida K (1999)	1
HSP90B1	3	CLTC	12	biochemical	Wan C (2015)	1
CSF1R	0	GRB2	2	two hybrid, pull down, affinity chromatography technology	Mancini A (1997), Mancini A (1997), Wang Y (1999)	3
CRK	0	SOCS1	1	pull down, two hybrid	De Sepulveda P (1999), Grossmann A (2015)	2
LCK	0	PIK3R1	6	pull down	Kapeller R (1994)	1
SH3KBP1	1	CRK	0	affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000)	2
IL7R	2	SOCS1	1	affinity chromatography technology	Ghazawi FM (2016)	1
SH3KBP1	1	INPP5D	2	affinity chromatography technology, two hybrid	Kowanetz K (2004), Conde C (2012)	2
DOK1	2	PLCG1	6	pull down	van Dijk TB (2000)	1
PTPN6	0	BCR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liedtke M (1998), Liedtke M (1998), Li X (2016)	3
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
PDGFRA	3	PIK3CA	8	affinity chromatography technology, enzymatic study	Valius M (1993), Valius M (1993)	2
GRAP	0	KIT	4	pull down	Feng GS (1996)	1
TP53	0	CLTC	12	affinity chromatography technology	Horikawa I (2014)	1
KIT	4	CD9	1	affinity chromatography technology, affinity chromatography technology	Anzai N (2002), Anzai N (2002)	2
GRB2	2	TEC	2	affinity chromatography technology	Bisson N (2011)	1
DOK1	2	YES1	1	pull down	van Dijk TB (2000)	1
PIK3R1	6	INPP5D	2	affinity chromatography technology	Zhang S (1999)	1
LYN	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Ren X (2003), Ren X (2003)	2
PTPN6	0	PIK3R1	6	two hybrid	Sathish JG (2001)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
CBLB	3	LCK	0	affinity chromatography technology	Kumar S (2011)	1
CRK	0	BCR	3	pull down, affinity chromatography technology	Ingham RJ (1996), Brehme M (2009)	2
SRC	2	GRB10	4	enzymatic study	Langlais P (2000)	1
DOK1	2	CRKL	1	pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, two hybrid	van Dijk TB (2000), Bhat A (1998), Bhat A (1998), Bhat A (1998), Bhat A (1998), Martelli MP (2001), Grossmann A (2015)	7
PIK3R2	3	PTPN11	20	affinity chromatography technology	Brehme M (2009)	1
CBL	7	PLCG1	6	far western blotting, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Tvorogov D (2002), Tvorogov D (2002), Tvorogov D (2002), Graham LJ (1998), Singh AJ (2007), Rellahan BL (2003), Rellahan BL (2003), Okabe S (2006), Choi JH (2003), Choi JH (2003), Braiman A (2006), Braiman A (2006), Braiman A (2006), Chen TC (2014)	14
CBLB	3	PTPN11	20	affinity chromatography technology	Hoff H (2007)	1
TEC	2	LYN	2	affinity chromatography technology	van Dijk TB (2000)	1
PIK3R1	6	JAK2	1	pull down, genetic interference	Ren SY (2005), Shen JP (2017)	2
STAT5B	3	JAK2	1	affinity chromatography technology, two hybrid, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Varghese LN (2014)	3
PTPN11	20	STAT1	1	two hybrid	Daakour S (2016)	1
PLCG1	6	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Matalon O (2016), Matalon O (2016)	2
BCR	3	PIK3CG	3	affinity chromatography technology, imaging technique	Skorski T (1995), Chen TC (2014)	2
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
PDGFRA	3	CRK	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Yokote K (1998), Matsumoto T (2000), Matsumoto T (2000), Chen TC (2014)	4
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
LYN	2	DOK1	2	enzymatic study, pull down, enzymatic study	van Dijk TB (2000), van Dijk TB (2000), Liang X (2002)	3
CRK	0	SOCS6	0	two hybrid	Grossmann A (2015)	1
LCK	0	PIK3CA	8	affinity chromatography technology, pull down	Sade H (2004), Prasad KV (1993)	2
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
PIK3R1	6	GRB10	4	affinity chromatography technology	Deng Y (2003)	1
LYN	2	HSP90B1	3	affinity chromatography technology	Zhu J (2013)	1
LYN	2	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
SH3KBP1	1	CBLB	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Szymkiewicz I (2002), Szymkiewicz I (2002), Szymkiewicz I (2002), Havrylov S (2009), Moncalian G (2006), Jozic D (2005), Jozic D (2005), Kowanetz K (2003), Ceregido MA (2013), Ceregido MA (2013), Ceregido MA (2013)	11
PIK3CA	8	STAT1	1	enzymatic study	Nguyen H (2001)	1
KIT	4	CD63	0	affinity chromatography technology, affinity chromatography technology	Anzai N (2002), Anzai N (2002)	2
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
CRKL	1	PTPN11	20	affinity chromatography technology	Chin H (1997)	1
CRKL	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down	Gesbert F (1998), Gelkop S (2001), Ren SY (2005)	3
LYN	2	JAK2	1	pull down	Chin H (1998)	1
SRC	2	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olayioye MA (1999), Cirri P (1997), Chang YJ (2004), Chang YJ (2004)	4
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
LYN	2	PIK3CG	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Pigazzi A (1999), Marcilla A (1995), Marcilla A (1995), Marcilla A (1995)	4
KIT	4	STAT5B	3	enzymatic study	Jahn T (2007)	1
SRC	2	JAK2	1	affinity chromatography technology	Liang K (2010)	1
LCK	0	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Venkitachalam S (2011), Venkitachalam S (2011)	2
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
CBL	7	PTPN6	0	affinity chromatography technology	Kant AM (2002)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
SOCS6	0	PIK3R1	6	affinity chromatography technology	Krebs DL (2002)	1
KIT	4	GRB2	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	De Sepulveda P (1999), Thoemmes K (1999), Feng GS (1996), Sun J (2007), Zhu MJ (2007), Wollberg P (2003), Brizzi MF (1996)	7
PDGFRA	3	CRKL	1	affinity chromatography technology, imaging technique	Yokote K (1998), Chen TC (2014)	2
TEC	2	SOCS1	1	pull down, two hybrid	Ohya K (1997), Ohya K (1997)	2
JAK2	1	TEC	2	affinity chromatography technology, enzymatic study	Takahashi-Tezuka M (1997), Yamashita Y (1998)	2
SRC	2	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
CBL	7	CSF1R	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mancini A (2002), Mancini A (2002), Mancini A (2002), Wilhelmsen K (2002), Wilhelmsen K (2002), Wang Y (1999), Wang Y (1999), Tanaka S (1995), Ota J (2000), Ota J (2000)	10
KIT	4	CRK	0	two hybrid	Yokouchi M (1997)	1
KIT	4	INPP5D	2	pull down	van Dijk TB (2000)	1
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
SOCS1	1	PIK3R1	6	two hybrid	Grossmann A (2015)	1
CSF1R	0	SOCS1	1	two hybrid, affinity chromatography technology, pull down	Bourette RP (2001), Bourette RP (2001), Bourette RP (2001)	3
PIK3R1	6	SH3KBP1	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Gout I (2000), Tossidou I (2010), Borthwick EB (2004), Borthwick EB (2004)	4
KIT	4	CSF2RA	1	imaging technique	Chen TC (2014)	1
PTPN11	20	PDGFRA	3	affinity chromatography technology, enzymatic study	Feng H (2012), Vogel W (1996)	2
TP53	0	PDGFRA	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
CBL	7	IL7R	2	affinity chromatography technology	Rathinam C (2010)	1
KIT	4	YES1	1	pull down	van Dijk TB (2000)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
PDGFRA	3	KIT	4	affinity chromatography technology	Zhu MJ (2007)	1
BCR	3	TP53	0	two hybrid, imaging technique	Stelzl U (2005), Chen TC (2014)	2
CRK	0	TP53	0	two hybrid	Grossmann A (2015)	1
DOK1	2	BCR	3	affinity chromatography technology, affinity chromatography technology, pull down	Bhat A (1998), Bhat A (1998), Bhat A (1998)	3
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
KIT	4	PTPRO	3	affinity chromatography technology	Taniguchi Y (1999)	1
PDGFRA	3	PLCG1	6	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study	Eriksson A (1995), Eriksson A (1995), Chen TC (2014), Valius M (1993), Valius M (1993)	5
CLTC	12	SRC	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Collin G (2007), Collin G (2007), Collin G (2007), Collin G (2007)	4
KIT	4	HSP90B1	3	affinity chromatography technology, affinity chromatography technology	Dong Y (2015), Dong Y (2015)	2
IRF3	4	CBL	7	affinity chromatography technology, affinity chromatography technology	Zhao X (2016), Zhao X (2016)	2
KIT	4	ILKAP	2	two hybrid	Yao Z (2017)	1
SH3KBP1	1	CLTC	12	affinity chromatography technology	Kowanetz K (2003)	1
CBLB	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Ettenberg SA (1999), Lavagna-Sevenier C (1998), Lavagna-Sevenier C (1998), Elly C (1999), Bandyopadhyay S (2010), Vinayagam A (2011), Bisson N (2011), Blagoev B (2003), Rolland T (2014), Huttlin EL (2017)	10
SRC	2	KIT	4	unspecified method	Wollberg P (2003)	1
MATK	2	SRC	2	enzymatic study	Avraham S (1995)	1
CBLB	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavagna-Sevenier C (1998), Elly C (1999), Elly C (1999), Alcazar I (2009), Fang D (2001)	5
PTPN6	0	STAT5B	3	affinity chromatography technology	Ram PA (1997)	1
IL7R	2	KIT	4	affinity chromatography technology, enzymatic study	Jahn T (2007), Jahn T (2007)	2
IRF3	4	KIT	4	affinity chromatography technology	Li X (2015)	1
JAK3	3	STAT5B	3	two hybrid	Fujitani Y (1997)	1
JAK2	1	PLCG1	6	affinity chromatography technology	Chang YJ (2004)	1
SRC	2	PTPN11	20	enzymatic study	Vogel W (1996)	1
HSP90B1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wu B (2015), Wu B (2015), Wu B (2015), Wu B (2015)	4
CBLB	3	PIK3R2	3	affinity chromatography technology	Alcazar I (2009)	1
SRC	2	TP53	0	enzymatic study	Huang YF (2014)	1
CSF2RA	1	PIK3R1	6	affinity chromatography technology	Dhar-Mascareno M (2003)	1
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
LCK	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
LCK	0	CBL	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005)	4
KIT	4	JAK3	3	enzymatic study	Jahn T (2007)	1
KIT	4	STYX	1	two hybrid	Yao Z (2017)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
IRF3	4	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Oliere S (2010), Oliere S (2010)	2
CRK	0	PIK3CA	8	affinity chromatography technology	Brehme M (2009)	1
STAT1	1	PDGFRA	3	imaging technique	Chen TC (2014)	1
CRK	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Larsson H (1999)	2
SOCS6	0	PIK3R2	3	affinity chromatography technology	Krebs DL (2002)	1
JAK2	1	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Jiao H (1996), Wu DW (2000)	2
KIT	4	SOCS1	1	two hybrid, affinity chromatography technology	De Sepulveda P (1999), De Sepulveda P (1999)	2
KIT	4	PIK3CG	3	imaging technique	Chen TC (2014)	1
LYN	2	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Taher TE (2002), Dombrosky-Ferlan PM (1997), Kaabeche K (2004), Wu J (2008), Tanaka S (1995), Marcilla A (1995)	6
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
INPP5D	2	BCR	3	affinity chromatography technology	Ruschmann J (2010)	1
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
CBL	7	PDGFRA	3	affinity chromatography technology, pull down	Bonita DP (1997), Bonita DP (1997)	2
JAK2	1	SOCS1	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yasukawa H (1999), Dif F (2001), Endo TA (1997), Endo TA (1997), Endo TA (1997), Yasukawa H (1999), Yasukawa H (1999), Pezet A (1999), Ungureanu D (2002), Masuhara M (1997), Ali S (2003), Monni R (2001), Monni R (2001), Piessevaux J (2008), Yu L (2009), Maruoka M (2017)	16
PTPN11	20	STAT5B	3	pull down, enzymatic study	Yu CL (2000), Yu CL (2000)	2
CSF1R	0	PIK3R1	6	affinity chromatography technology, imaging technique	Wang Y (1999), Chen TC (2014)	2
PIK3CA	8	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sattler M (1997), Sattler M (1997), Chernock RD (2001), Chernock RD (2001), Brehme M (2009)	5
SRC	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Narita T (2005), Schroeder B (2012)	2
GRB2	2	INPP5D	2	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavanaugh WM (1996), Kavanaugh WM (1996), de Castro RO (2012), Ho JM (2002)	4
TP53	0	SOCS1	1	affinity chromatography technology, pull down, affinity chromatography technology	Calabrese V (2009), Calabrese V (2009), Calabrese V (2009)	3
PTPN6	0	LCK	0	enzymatic study, enzymatic study, pull down	Yu CL (2000), Chiang GG (2001), Lorenz U (1994)	3
JAK3	3	JAK2	1	affinity chromatography technology	Doucet C (2002)	1
KIT	4	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng S (2005), Brizzi MF (1996), Dong Y (2015)	3
CRKL	1	SOCS1	1	two hybrid	Grossmann A (2015)	1
BCR	3	KIT	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Hallek M (1996), Hallek M (1996), Chen TC (2014)	3
CD63	0	CD9	1	affinity chromatography technology	Radford KJ (1996)	1
PDGFRA	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, imaging technique	Zhu MJ (2007), Zhu MJ (2007), Chen TC (2014)	3
DOK1	2	PIK3R1	6	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
PTPN11	20	PTPN6	0	affinity chromatography technology	Li X (2016)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
BCR	3	CRKL	1	affinity chromatography technology, two hybrid, two hybrid, far western blotting, affinity chromatography technology	Heaney C (1997), Heaney C (1997), Kolibaba KS (1999), Kolibaba KS (1999), Million RP (2004)	5
SRC	2	PTPN6	0	enzymatic study	Frank C (2004)	1
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
SOCS6	0	KIT	4	affinity chromatography technology, enzymatic study, x-ray crystallography	Zadjali F (2011), Zadjali F (2011), Zadjali F (2011)	3
CBL	7	BCR	3	pull down, pull down, affinity chromatography technology, enzymatic study	Gaston I (2004), Panchamoorthy G (1996), Brehme M (2009), Tsukahara F (2010)	4
CSF1R	0	SRC	2	affinity chromatography technology	Courtneidge SA (1993)	1
KIT	4	TP53	0	genetic interference	Shen JP (2017)	1
JAK2	1	STAT1	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Cheng MB (2010), Cheng MB (2010), Manea A (2010), Andl CD (2004), Chang YJ (2004)	5
CRKL	1	INPP5D	2	pull down, affinity chromatography technology	Arai A (2001), Arai A (2001)	2
MATK	2	KIT	4	pull down, pull down	Jhun BH (1995), Price DJ (1997)	2
KIT	4	PTPN6	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kozlowski M (1998), Kozlowski M (1998), Kozlowski M (1998), Yi T (1993), Yi T (1993)	5
DOK1	2	CRK	0	unspecified method	Liu BA (2012)	1
KIT	4	CD81	0	affinity chromatography technology, affinity chromatography technology	Anzai N (2002), Anzai N (2002)	2
GRB2	2	CLTC	12	affinity chromatography technology	Brehme M (2009)	1
PIK3R2	3	BCR	3	affinity chromatography technology	Brehme M (2009)	1
KIT	4	KIT	4	affinity chromatography technology	Tsujimura T (1999)	1
SH3KBP1	1	KIT	4	affinity chromatography technology	Szymkiewicz I (2002)	1
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
CD81	0	JAK3	3	two hybrid	Wang J (2011)	1
GRB2	2	DOK1	2	affinity chromatography technology	Kepley CL (2004)	1
GRB7	1	KIT	4	pull down, unspecified method	Thoemmes K (1999), Wollberg P (2003)	2
CSF1R	0	PIK3R2	3	pull down	Gout I (1992)	1
KIT	4	JAK2	1	affinity chromatography technology	Brizzi MF (1994)	1
CRK	0	MPDZ	6	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
INPP5D	2	CBL	7	affinity chromatography technology	Bao M (2012)	1
KIT	4	CLTC	12	affinity chromatography technology	Broudy VC (1999)	1
TEC	2	DOK1	2	affinity chromatography technology, enzymatic study, pull down, enzymatic study	van Dijk TB (2000), van Dijk TB (2000), van Dijk TB (2000), Liang X (2002)	4
PDGFRA	3	GRB2	2	affinity chromatography technology, affinity chromatography technology	Bazenet CE (1996), Severe N (2011)	2
INPP5D	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu L (1997), Chernock RD (2001), Chernock RD (2001)	3
LCK	0	KIT	4	affinity chromatography technology	Krystal GW (1998)	1
CSF1R	0	PIK3CA	8	pull down, two hybrid	Mancini A (1997), Mancini A (1997)	2
CBL	7	CRKL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Alsayed Y (2000), Alsayed Y (2000), Kyono WT (1998), Lin H (2001), Park RK (1998), Taher TE (2002), Sattler M (1997), Erdreich-Epstein A (1999), Erdreich-Epstein A (1999), Sattler M (1997), Sattler M (1997), Gesbert F (1998), Chin H (1997), Feshchenko EA (2004), Izadi KD (1998), de Jong R (1995), de Jong R (1995), Boussiotis VA (1997), Boussiotis VA (1997), Barber DL (1997), Uemura N (1999), Okabe S (2006), Alsayed Y (2000), Alsayed Y (2000), Brenner B (2001), van Leeuwen JE (1999), Ribon V (1996), Bhat A (1997), Bhat A (1997), Huang JY (2000), Chernock RD (2001), Chernock RD (2001), Grossmann AH (2004), Sakamoto H (2004), Nishihara T (2003), Peterson ME (2008), Fukazawa T (1996), Martelli MP (2001), Joshi S (2014), Grossmann A (2015)	40
CRK	0	CBLB	3	affinity chromatography technology, two hybrid, two hybrid	Brehme M (2009), Grossmann A (2015), Grossmann A (2015)	3
CBLB	3	KIT	4	affinity chromatography technology	Szymkiewicz I (2002)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
CSF1R	0	YES1	1	affinity chromatography technology	Courtneidge SA (1993)	1
TEC	2	PIK3R2	3	two hybrid	Takahashi-Tezuka M (1997)	1
INPP5D	2	DOK1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000), van Dijk TB (2000), Kepley CL (2004)	4
CD63	0	CD81	0	biochemical	Booth AM (2006)	1
BCR	3	PIK3R1	6	far western blotting	Weinger JG (2008)	1
HSP90B1	3	STAT1	1	affinity chromatography technology	Maruvada R (2008)	1
KIT	4	PLCG1	6	pull down, pull down, imaging technique	van Dijk TB (2000), Jhun BH (1995), Chen TC (2014)	3
CBLB	3	CRKL	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Elly C (1999), Elly C (1999), Grossmann A (2015)	3
GRB2	2	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	3
KIT	4	MPDZ	6	two hybrid, pull down, pull down	Mancini A (2000), Mancini A (2000), Mancini A (2000)	3
KIT	4	GRB10	4	two hybrid, pull down, affinity chromatography technology	Jahn T (2002), Jahn T (2002), Jahn T (2002)	3
KIT	4	RPS6KB1	1	genetic interference	Shen JP (2017)	1
SOCS1	1	PTPN11	20	affinity chromatography technology	Ali S (2003)	1
CD81	0	CD9	1	affinity chromatography technology, biochemical	Radford KJ (1996), Horvath G (1998)	2
DOK1	2	KIT	4	affinity chromatography technology, pull down	Liang X (2002), Liang X (2002)	2
IL7R	2	JAK3	3	affinity chromatography technology	Jahn T (2007)	1
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3
KIT	4	PIK3CA	8	affinity chromatography technology	Furitsu T (1993)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1
STAT1	1	RPS6KB1	1	biochemical	Fielhaber JA (2009)	1
KIT	4	SMO	0	genetic interference	Shen JP (2017)	1
KIT	4	CRKL	1	pull down, affinity chromatography technology	van Dijk TB (2000), Sattler M (1997)	2
YES1	1	CBL	7	pull down	Shishido T (2000)	1
PTPN11	20	KIT	4	pull down, affinity chromatography technology, unspecified method	Tauchi T (1994), Kozlowski M (1998), Wollberg P (2003)	3