PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXW11	2	PPM1A	1	affinity chromatography technology	Coyaud E (2015)	1
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
PTPN11	20	CDH5	2	affinity chromatography technology	Ukropec JA (2000)	1
COL18A1	8	KDR	4	pull down	Kim YM (2002)	1
IQGAP1	1	MYO1C	5	affinity chromatography technology	Hein MY (2015)	1
ANXA5	0	APP	1	pull down	Olah J (2011)	1
SRC	2	IQGAP1	1	affinity chromatography technology	Meyer RD (2008)	1
PTPN12	2	EPN1	4	biochemical	Kristensen AR (2012)	1
PTPN11	20	CAV1	0	affinity chromatography technology	Caselli A (2002)	1
CBL	7	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Erdreich-Epstein A (1999), Miyoshi-Akiyama T (2001), Izadi KD (1998), Izadi KD (1998), Wunderlich L (1999), Shishido T (2000), Okabe S (2006), Adler CE (2000), Adler CE (2000), Buvall L (2013), Buvall L (2013), Buvall L (2013), Buvall L (2013)	13
KDR	4	CDH5	2	affinity chromatography technology	Zanetti A (2002)	1
PTPN12	2	SHC1	0	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Habib T (1994), Charest A (1996), Charest A (1996), Habib T (1994), Habib T (1994), Brehme M (2009), Li J (2013), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017)	10
SHC1	0	IQGAP1	1	affinity chromatography technology	Brehme M (2009)	1
SHC1	0	DNM2	2	affinity chromatography technology	Brehme M (2009)	1
VEGFA	3	FLT1	4	pull down, affinity chromatography technology	Allain B (2012), Huttlin EL (2017)	2
SCUBE2	3	KDR	4	affinity chromatography technology, affinity chromatography technology	Lin YC (2017), Lin YC (2017)	2
DUSP19	0	MAPK1	1	affinity chromatography technology	Li X (2016)	1
CAV1	0	MAPK1	1	affinity chromatography technology	Hua H (2003)	1
TP53	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dhar SK (2006), Kurki S (2004), Kurki S (2004), Lambert B (2006), Colombo E (2002), Colombo E (2002), Colombo E (2002), Fogeron ML (2013), Li J (2005)	9
CSNK1D	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
KDR	4	PTPRR	3	two hybrid	Yao Z (2017)	1
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
KDR	4	ZSCAN21	3	affinity chromatography technology	Hein MY (2015)	1
IQGAP1	1	ANXA5	0	biochemical	Wan C (2015)	1
KDR	4	ACP1	4	two hybrid	Huang L (1999)	1
KDR	4	PTPN6	0	two hybrid, affinity chromatography technology	Yao Z (2017), Seo DW (2003)	2
KDR	4	PTPN12	2	two hybrid	Yao Z (2017)	1
ZCCHC6	2	APP	1	pull down	Olah J (2011)	1
KDR	4	YWHAG	5	affinity chromatography technology	Hein MY (2015)	1
APP	1	COL18A1	8	affinity chromatography technology	Huttlin EL (2017)	1
GRB10	4	APP	1	pull down	Olah J (2011)	1
SH2D2A	2	SRC	2	unspecified method, affinity chromatography technology	Sun Z (2012), Sun Z (2012)	2
FLT1	4	KDR	4	enzymatic study, affinity chromatography technology	Autiero M (2003), Raikwar NS (2014)	2
PLXNA1	14	NRP1	2	affinity chromatography technology	Takahashi T (2001)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
MAPK1	1	ILKAP	2	biochemical	Wan C (2015)	1
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
FLT1	4	PTPN11	20	imaging technique	Chen TC (2014)	1
BTRC	1	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
CAV1	0	PLCG1	6	affinity chromatography technology	Boettcher JP (2010)	1
SHC1	0	APP	1	pull down, affinity chromatography technology	Tarr PE (2002), Tarr PE (2002)	2
SRC	2	GRB10	4	enzymatic study	Langlais P (2000)	1
CBL	7	PLCG1	6	far western blotting, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Tvorogov D (2002), Tvorogov D (2002), Tvorogov D (2002), Graham LJ (1998), Singh AJ (2007), Rellahan BL (2003), Rellahan BL (2003), Okabe S (2006), Choi JH (2003), Choi JH (2003), Braiman A (2006), Braiman A (2006), Braiman A (2006), Chen TC (2014)	14
CSNK1D	3	KDR	4	affinity chromatography technology, enzymatic study	Shaik S (2012), Shaik S (2012)	2
PTPRR	3	MAPK1	1	pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Huttlin EL (2015), Chen TC (2014), St-Denis N (2016), Huttlin EL (2017)	10
PLCG1	6	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Matalon O (2016), Matalon O (2016)	2
FBXO25	1	MYO1C	5	affinity chromatography technology	Teixeira FR (2010)	1
PLCG1	6	RASA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jabado N (1998), Jabado N (1997), Jabado N (1997)	3
FBXO25	1	EPN1	4	enzymatic study	Teixeira FR (2013)	1
SHC1	0	MYO1C	5	affinity chromatography technology	Brehme M (2009)	1
MYO1C	5	CBL	7	two hybrid, affinity chromatography technology	Robertson H (1997), Brehme M (2009)	2
PTPN6	0	PTPN12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Li X (2016)	2
FBXW11	2	KDR	4	two hybrid, affinity chromatography technology	Vinayagam A (2011), Shaik S (2012)	2
KDR	4	RASA1	3	affinity chromatography technology	DAngelo G (1999)	1
DNM2	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SHB	4	PLCG1	6	affinity chromatography technology	Lindholm CK (1999)	1
MAPK1	1	SHC1	0	affinity chromatography technology	Dinerstein-Cali H (2000)	1
KDR	4	ANXA5	0	two hybrid, pull down	Wen Y (1999), Wen Y (1999)	2
FBXO25	1	IQGAP1	1	affinity chromatography technology	Teixeira FR (2010)	1
KDR	4	ILKAP	2	two hybrid	Yao Z (2017)	1
RASA1	3	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, pull down, affinity chromatography technology	Holland SJ (1997), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011)	7
FBXW11	2	TP53	0	affinity chromatography technology	Low TY (2014)	1
MYO1C	5	PALLD	6	affinity chromatography technology	Hein MY (2015)	1
FBXO25	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
KDR	4	ZCCHC6	2	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
NPM1	0	KDR	4	affinity chromatography technology	Chen R (2013)	1
KDR	4	NAXD	1	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
APP	1	SRC	2	affinity chromatography technology	Austin SA (2009)	1
RASA1	3	BTRC	1	genetic interference	Spiegelman VS (2002)	1
KDR	4	PPM1A	1	two hybrid	Yao Z (2017)	1
CBL	7	PTPN6	0	affinity chromatography technology	Kant AM (2002)	1
KDR	4	KDR	4	enzymatic study, imaging technique, enzymatic study, enzymatic study	Mamluk R (2010), Mamluk R (2010), Dentelli P (2005), Dougher M (1999)	4
FLT1	4	SHC1	0	two hybrid	Warner AJ (2000)	1
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
GRB2	2	YWHAG	5	affinity chromatography technology	Bisson N (2011)	1
FBXO25	1	NPM1	0	affinity chromatography technology	Teixeira FR (2010)	1
TXNIP	2	KDR	4	affinity chromatography technology	Park SY (2013)	1
KDR	4	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
NPM1	0	GRB2	2	affinity chromatography technology, pull down	Crockett DK (2004), Bai RY (1998)	2
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
KDR	4	STYX	1	two hybrid	Yao Z (2017)	1
KDR	4	AAR2	2	affinity chromatography technology	Hein MY (2015)	1
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
KDR	4	DNM2	2	affinity chromatography technology	Bhattacharya R (2005)	1
CUL1	7	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	IQGAP1	1	affinity chromatography technology	Fogeron ML (2013)	1
KDR	4	TP53	0	genetic interference	Ye H (2016)	1
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
VEGFA	3	KDR	4	enzymatic study, pull down, pull down, imaging technique, pull down	Luque A (2003), Di Benedetto M (2008), Tirand L (2006), Koutsioumpa M (2015), Patel NS (2010)	5
NRP1	2	VEGFA	3	pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Mamluk R (2002), Soker S (1998), Soker S (1998), Parker MW (2012), Parker MW (2012), Di Benedetto M (2008), Tirand L (2006), Allain B (2012), Novoa A (2010)	9
KDR	4	PALLD	6	affinity chromatography technology	Hein MY (2015)	1
KDR	4	APP	1	pull down, affinity chromatography technology, affinity chromatography technology	Patel NS (2010), Patel NS (2010), Patel NS (2010)	3
MAPK1	1	STYX	1	affinity chromatography technology, protein complementation assay	Reiterer V (2017), Reiterer V (2017)	2
SRC	2	PTPN11	20	enzymatic study	Vogel W (1996)	1
SHB	4	KDR	4	affinity chromatography technology	Holmqvist K (2004)	1
NPM1	0	APP	1	pull down	Olah J (2011)	1
SHC1	0	CDH5	2	affinity chromatography technology	Zanetti A (2002)	1
SHB	4	SRC	2	pull down, affinity chromatography technology	Karlsson T (1995), Karlsson T (1995)	2
KDR	4	CAV1	0	biochemical	Tiwari A (2013)	1
ITGB3	6	KDR	4	imaging technique, affinity chromatography technology	Koutsioumpa M (2015), Koutsioumpa M (2015)	2
SRC	2	TP53	0	enzymatic study	Huang YF (2014)	1
APP	1	ZSCAN21	3	pull down	Virok DP (2011)	1
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
KDR	4	PLXNA1	14	affinity chromatography technology	Toyofuku T (2004)	1
CAV1	0	SRC	2	pull down	Li S (1996)	1
FLT1	4	PLCG1	6	pull down, two hybrid	Cunningham SA (1997), Cunningham SA (1997)	2
EPN1	4	KDR	4	affinity chromatography technology, affinity chromatography technology	Pasula S (2012), Pasula S (2012)	2
RASA1	3	SRC	2	affinity chromatography technology, enzymatic study	Brott BK (1991), Giglione C (2001)	2
KDR	4	GRB2	2	affinity chromatography technology	DAngelo G (1999)	1
GRB10	4	KDR	4	two hybrid	Giorgetti-Peraldi S (2001)	1
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
CBL	7	KDR	4	pull down, affinity chromatography technology	Singh AJ (2007), Wang Y (2009)	2
CSNK1D	3	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Kulikov R (2006), Alsheich-Bartok O (2008), Alsheich-Bartok O (2008), Wolff S (2006), Chen TC (2014)	5
SRC	2	ITGB3	6	enzymatic study	Kirk RI (2000)	1
RASA1	3	APP	1	pull down	Olah J (2011)	1
DNM2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Feng H (2012), Feng H (2012)	2
KDR	4	DUSP19	0	two hybrid	Yao Z (2017)	1
KDR	4	NCK1	0	affinity chromatography technology	Ratcliffe KE (2002)	1
KDR	4	PLCG1	6	pull down	Cunningham SA (1997)	1
TP53	0	TXNIP	2	affinity chromatography technology	Suh HW (2013)	1
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
FBXW11	2	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
BTRC	1	KDR	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Meyer RD (2011), Meyer RD (2011), Shaik S (2012), Shaik S (2012)	4
CSNK1D	3	PPM1B	2	biochemical	Wan C (2015)	1
GRB2	2	IQGAP1	1	affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Brehme M (2009)	2
CUL1	7	KDR	4	affinity chromatography technology, affinity chromatography technology	Shaik S (2012), Shaik S (2012)	2
KDR	4	PTPN11	20	two hybrid, affinity chromatography technology, far western blotting	Yao Z (2017), Mitola S (2006), Mitola S (2006)	3
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
TP53	0	MYO1C	5	affinity chromatography technology	Horikawa I (2014)	1
PTPN11	20	PTPN6	0	affinity chromatography technology	Li X (2016)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
SRC	2	PTPN6	0	enzymatic study	Frank C (2004)	1
IQGAP1	1	MAPK1	1	biochemical, affinity chromatography technology	Bourguignon LY (2005), Bourguignon LY (2005)	2
BTRC	1	RAB5A	0	bioid	Coyaud E (2015)	1
PTPN12	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology	Charest A (1997), Charest A (1997), Bisson N (2011)	3
SHB	4	GRB2	2	affinity chromatography technology	Welsh M (1998)	1
NPM1	0	PLCG1	6	pull down, affinity chromatography technology	Bai RY (1998), Bai RY (1998)	2
PPM1A	1	PPM1B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KDR	4	GATC	0	affinity chromatography technology	Hein MY (2015)	1
CBL	7	IQGAP1	1	affinity chromatography technology	Brehme M (2009)	1
KDR	4	MAPK1	1	enzymatic study	Mamluk R (2010)	1
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
GRB2	2	RASA1	3	affinity chromatography technology	Lamprecht R (2002)	1
FLT1	4	SHC2	3	two hybrid, two hybrid	Warner AJ (2000), Igarashi K (1998)	2
SRC	2	MAPK1	1	affinity chromatography technology	Lee J (2013)	1
SHC1	0	SHC2	3	affinity chromatography technology	Huttlin EL (2017)	1
NRP1	2	KDR	4	affinity chromatography technology	Ohsaka A (2009)	1
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
ITGB3	6	SHC1	0	affinity chromatography technology, unspecified method	Lee DY (2010), Kirk RI (2000)	2
STYX	1	CUL1	7	affinity chromatography technology	Li X (2016)	1
AIMP2	0	IQGAP1	1	biochemical	Kristensen AR (2012)	1
KDR	4	MYO1C	5	biochemical	Tiwari A (2013)	1
SHC2	3	GRB2	2	affinity chromatography technology	Wills MK (2014)	1
DNM2	2	SRC	2	pull down	Solomaha E (2005)	1
FLT1	4	CBL	7	affinity chromatography technology	Raikwar NS (2014)	1
KDR	4	SHC2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Warner AJ (2000), Warner AJ (2000), Warner AJ (2000), Ratcliffe KE (2002), Ratcliffe KE (2002), Igarashi K (1998)	6
DNM2	2	GRB2	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Solomaha E (2005), Brehme M (2009), Bisson N (2011), Elhamdani A (2006), Wang J (2011), Huttlin EL (2017)	6
KDR	4	SH2D2A	2	unspecified method, affinity chromatography technology	Sun Z (2012), Sun Z (2012)	2
SHC1	0	SRC	2	pull down	Schueller AC (2008)	1
APP	1	CAV1	0	biochemical, unspecified method	Ikezu T (1998), Ikezu T (1998)	2
SHC1	0	KDR	4	affinity chromatography technology, affinity chromatography technology	Zanetti A (2002), DAngelo G (1999)	2
FBXO25	1	KDR	4	enzymatic study	Teixeira FR (2013)	1
AIMP2	0	KDR	4	two hybrid	Vinayagam A (2011)	1
PTPN11	20	TXNIP	2	x-ray crystallography, pull down, x-ray crystallography, pull down	Liu Y (2016), Liu Y (2016), Liu S (2016), Liu S (2016)	4
IQGAP1	1	KDR	4	affinity chromatography technology	Meyer RD (2008)	1
TXNIP	2	RAB5A	0	affinity chromatography technology	Park SY (2013)	1
CSF2RB	6	SHC1	0	affinity chromatography technology	Bone H (2000)	1
TP53	0	AIMP2	0	affinity chromatography technology, pull down, two hybrid, pull down	Han JM (2008), Han JM (2008), Han JM (2008), Han JM (2008)	4
CSF2RB	6	PTPN11	20	affinity chromatography technology, pull down	Bone H (1997), Bone H (1997)	2
ILKAP	2	MYO1C	5	affinity chromatography technology	Yadav L (2017)	1
PTPN6	0	CAV1	0	affinity chromatography technology	Caselli A (2002)	1
AIMP2	0	APP	1	pull down	Olah J (2011)	1
PTPN12	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
KDR	4	PPM1B	2	two hybrid	Yao Z (2017)	1
CSF2RB	6	PTPN6	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Bone H (1997), Bone H (1997), Yi T (1993), Yi T (1993)	4
KDR	4	CSF2RB	6	affinity chromatography technology, affinity chromatography technology	Dentelli P (2005), Dentelli P (2005)	2
VEGFD	3	KDR	4	pull down	Achen MG (1998)	1
RAB5A	0	KDR	4	affinity chromatography technology	Park SY (2013)	1
SRC	2	KDR	4	affinity chromatography technology, affinity chromatography technology, unspecified method	Meyer RD (2008), Gavard J (2008), Sun Z (2012)	3