PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
JAK3	3	MTF2	4	affinity chromatography technology	Hein MY (2015)	1
TYK2	1	CCT3	1	affinity chromatography technology	So J (2015)	1
TCP1	0	CCT2	1	affinity chromatography technology, biochemical, biochemical, biochemical, biochemical	Gingras AC (2005), Imai Y (2003), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
JAK3	3	SPTLC1	1	affinity chromatography technology	Hein MY (2015)	1
JAK3	3	TCP1	0	affinity chromatography technology, affinity chromatography technology	So J (2015), Hein MY (2015)	2
GNAS	9	MAGED2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Laghmani K (2016), Huttlin EL (2017)	3
PRMT5	3	CDK4	2	affinity chromatography technology	Aggarwal P (2010)	1
CSNK1E	0	PRMT5	3	affinity chromatography technology	Varjosalo M (2013)	1
JAK2	1	STAM	3	enzymatic study, affinity chromatography technology	Takeshita T (1997), Takeshita T (1997)	2
TYK2	1	JAK1	6	affinity chromatography technology	Domanski P (1995)	1
CXCR4	0	JAK3	3	affinity chromatography technology	Vila-Coro AJ (1999)	1
JAK3	3	STAT5A	4	two hybrid, affinity chromatography technology	Fujitani Y (1997), Cheng H (2008)	2
CRY1	0	CCT6A	1	affinity chromatography technology	Papp SJ (2015)	1
IRS1	7	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
SOCS3	0	LEPR	3	pull down, affinity chromatography technology	Bjorbak C (2000), Palianopoulou M (2011)	2
CCT2	1	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
JAK1	6	STAM2	0	enzymatic study, affinity chromatography technology	Pandey A (2000), Endo K (2000)	2
JAK3	3	CCT8	0	affinity chromatography technology, affinity chromatography technology	So J (2015), Hein MY (2015)	2
ARAF	0	BAG2	0	affinity chromatography technology	So J (2015)	1
CDK1	0	TCP1	0	affinity chromatography technology	Hein MY (2015)	1
JAK3	3	TIAF1	0	two hybrid, affinity chromatography technology	Ji H (2000), Ji H (2000)	2
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
STAT5A	4	JAK2	1	affinity chromatography technology, two hybrid, pull down, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Fujitani Y (1997), Gouilleux F (1994)	4
JAK3	3	IL2RG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miyazaki T (1994), Russell SM (1994), Warren KJ (2016)	3
CDK1	0	CCT4	2	affinity chromatography technology	Hein MY (2015)	1
JAK1	6	STAT3	0	pull down, affinity chromatography technology, affinity chromatography technology	Ueda T (2002), Spiekermann K (2001), Andl CD (2004)	3
ALK	8	JAK3	3	affinity chromatography technology, affinity chromatography technology	Zamo A (2002), Crockett DK (2004)	2
TCP1	0	CCT4	2	affinity chromatography technology, biochemical, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
STAM2	0	TYK2	1	affinity chromatography technology	Endo K (2000)	1
TYK2	1	CCT2	1	affinity chromatography technology	So J (2015)	1
ERBB3	3	TUBA4A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Li J (2013), Huttlin EL (2017)	3
ARAF	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
JAK3	3	INPP5B	2	affinity chromatography technology	Hein MY (2015)	1
MAGED2	1	TUBA4A	1	affinity chromatography technology	Fogeron ML (2013)	1
SRRM2	18	TUBA4A	1	affinity chromatography technology	McCracken S (2005)	1
DHX16	5	CSNK1E	0	biochemical	Wan C (2015)	1
CCT8	0	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PRMT5	3	JAK1	6	pull down	Pollack BP (1999)	1
SHB	4	JAK3	3	pull down	Lindholm CK (2002)	1
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
ERBB3	3	PTK2B	6	affinity chromatography technology	Verma N (2017)	1
PRMT5	3	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, protein complementation assay	Zhang HT (2016), Zhang HT (2016), Zhang HT (2016), Zhang HT (2016), Zhang HT (2016)	5
PRMT5	3	TYK2	1	pull down	Pollack BP (1999)	1
JAK3	3	TYK2	1	affinity chromatography technology	Doucet C (2002)	1
JAK3	3	STAT3	0	affinity chromatography technology	Doucet C (2002)	1
STAT5B	3	JAK2	1	affinity chromatography technology, two hybrid, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Varghese LN (2014)	3
IL4R	1	JAK1	6	pull down, affinity chromatography technology, affinity chromatography technology	Usacheva A (2002), Seki Y (2002), Huttlin EL (2017)	3
IL4R	1	STAT6	1	pull down, unspecified method, pull down	Mikita T (1998), Hershey GK (1997), Hershey GK (1997)	3
CCT4	2	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
MAGED2	1	NAP1L4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Laghmani K (2016), Huttlin EL (2017)	3
CDK1	0	JAK3	3	two hybrid	Wang J (2011)	1
JAK3	3	SOCS3	0	affinity chromatography technology	Cho-Vega JH (2004)	1
JAK3	3	WDR46	3	affinity chromatography technology	Hein MY (2015)	1
IL4R	1	JAK2	1	affinity chromatography technology	Murata T (1996)	1
ALK	8	STAT3	0	affinity chromatography technology, affinity chromatography technology	Crockett DK (2004), Crockett DK (2004)	2
JAK3	3	NAP1L1	2	affinity chromatography technology	So J (2015)	1
IL2RG	0	JAK2	1	affinity chromatography technology	Tanaka N (1994)	1
IL4R	1	JAK3	3	affinity chromatography technology	Doucet C (2002)	1
JAK3	3	DECR1	2	affinity chromatography technology	Hein MY (2015)	1
JAK3	3	DHX16	5	affinity chromatography technology	Hein MY (2015)	1
IL2RG	0	IL4R	1	affinity chromatography technology	Seki Y (2002)	1
CCT3	1	CCT8	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
CCT2	1	CCT4	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
JAK3	3	RNPS1	1	affinity chromatography technology	So J (2015)	1
JAK3	3	RAB11A	4	affinity chromatography technology	Hein MY (2015)	1
STAM2	0	JAK2	1	affinity chromatography technology	Endo K (2000)	1
JAK3	3	TUBB1	1	affinity chromatography technology	So J (2015)	1
KIT	4	STAT5B	3	enzymatic study	Jahn T (2007)	1
IKBKG	0	JAK3	3	pull down	Fenner BJ (2010)	1
MAGED2	1	NAP1L1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Huttlin EL (2015), Laghmani K (2016)	3
CD3E	0	JAK3	3	affinity chromatography technology	Tomita K (2001)	1
CDK1	0	RNPS1	1	affinity chromatography technology	Malty RH (2017)	1
IKBKG	0	ALK	8	pull down	Fenner BJ (2010)	1
PTK2B	6	JAK3	3	affinity chromatography technology	Miyazaki T (1998)	1
TYK2	1	CCT4	2	affinity chromatography technology	So J (2015)	1
JAK2	1	PTK2B	6	affinity chromatography technology	Frank GD (2002)	1
ARAF	0	TCP1	0	affinity chromatography technology	So J (2015)	1
STAT5B	3	STAT3	0	imaging technique	Chen TC (2014)	1
CDK4	2	JAK3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAT3	0	STAT6	1	two hybrid	Ravasi T (2010)	1
JAK3	3	CENPC	0	affinity chromatography technology	Hein MY (2015)	1
TYK2	1	TUBA4A	1	affinity chromatography technology	So J (2015)	1
RNPS1	1	GPATCH8	5	two hybrid, affinity chromatography technology	Sakashita E (2004), Hein MY (2015)	2
LNX1	7	TYK2	1	affinity chromatography technology	Wolting CD (2011)	1
JAK3	3	BAG2	0	affinity chromatography technology	So J (2015)	1
IL4R	1	TYK2	1	affinity chromatography technology	Huttlin EL (2017)	1
STAT5B	3	CD247	1	affinity chromatography technology	Welte T (1999)	1
NMI	3	STAT3	0	pull down	Zhu M (1999)	1
JAK3	3	GEMIN6	0	affinity chromatography technology	Hein MY (2015)	1
JAK2	1	ERBB3	3	unspecified method	Jones RB (2006)	1
JAK3	3	TAF1	9	affinity chromatography technology	Hein MY (2015)	1
CD81	0	TUBA4A	1	affinity chromatography technology	Perez-Hernandez D (2013)	1
JAK3	3	GNAS	9	affinity chromatography technology	So J (2015)	1
JAK3	3	CCT4	2	affinity chromatography technology, affinity chromatography technology	So J (2015), Hein MY (2015)	2
JAK3	3	SRRM2	18	affinity chromatography technology	So J (2015)	1
SHB	4	JAK1	6	pull down	Lindholm CK (2002)	1
APOA1	0	JAK3	3	two hybrid	Wang J (2011)	1
PRMT5	3	JAK3	3	pull down	Pollack BP (1999)	1
CD81	0	CCT3	1	affinity chromatography technology	Perez-Hernandez D (2013)	1
IRS1	7	ALK	8	affinity chromatography technology	Crockett DK (2004)	1
STAM	3	STAM2	0	imaging technique	Kanazawa C (2003)	1
RNPS1	1	SRRM2	18	affinity chromatography technology, biochemical	Ewing RM (2007), Wan C (2015)	2
TCP1	0	CCT6A	1	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
CCT2	1	CCT8	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
JAK3	3	CAPN2	1	affinity chromatography technology	Hein MY (2015)	1
TYK2	1	TCP1	0	affinity chromatography technology	So J (2015)	1
STAT5A	4	STAT5B	3	affinity chromatography technology	Huttlin EL (2017)	1
SHB	4	IL2RG	0	pull down	Lindholm CK (2002)	1
CRY1	0	CCT8	0	affinity chromatography technology	Papp SJ (2015)	1
JAK3	3	CRY1	0	affinity chromatography technology	Hein MY (2015)	1
IL2RG	0	JAK1	6	affinity chromatography technology	Tanaka N (1994)	1
JAK3	3	MRPL23	1	affinity chromatography technology	Hein MY (2015)	1
ARAF	0	STUB1	4	affinity chromatography technology	So J (2015)	1
IL7R	2	KIT	4	affinity chromatography technology, enzymatic study	Jahn T (2007), Jahn T (2007)	2
JAK3	3	STAT5B	3	two hybrid	Fujitani Y (1997)	1
UHRF2	1	CDK4	2	far western blotting	Mori T (2011)	1
CD247	1	JAK3	3	affinity chromatography technology, pull down	Tomita K (2001), Tomita K (2001)	2
TYK2	1	CCT8	0	affinity chromatography technology	So J (2015)	1
JAK1	6	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Johnston JA (1995)	2
JAK1	6	STAT6	1	enzymatic study	Mikita T (1998)	1
JAK2	1	STAT3	0	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ram PA (1997), Manea A (2010), Andl CD (2004), Kamakura S (2004), He K (2013), Kucia-Tran JA (2016), M L (2016)	7
KIT	4	JAK3	3	enzymatic study	Jahn T (2007)	1
JAK3	3	COX4I1	4	affinity chromatography technology	Hein MY (2015)	1
CD81	0	CCT4	2	affinity chromatography technology	Perez-Hernandez D (2013)	1
NAP1L1	2	GNAS	9	affinity chromatography technology	Huttlin EL (2017)	1
STAT5A	4	CD247	1	affinity chromatography technology	Welte T (1999)	1
ALK	8	JAK2	1	affinity chromatography technology	Crockett DK (2004)	1
NAP1L1	2	NAP1L4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	4
JAK3	3	STAT6	1	affinity chromatography technology	Doucet C (2002)	1
CXCR4	0	STAM	3	imaging technique, biochemical	Malik R (2010), Malik R (2012)	2
STAM2	0	JAK3	3	affinity chromatography technology	Endo K (2000)	1
JAK3	3	JAK1	6	affinity chromatography technology	Doucet C (2002)	1
NMI	3	STAT5B	3	two hybrid	Zhu M (1999)	1
SOCS3	0	CXCR4	0	affinity chromatography technology	Soriano SF (2002)	1
STAM	3	STUB1	4	biochemical	Havugimana PC (2012)	1
JAK3	3	RAB11FIP2	2	affinity chromatography technology	Hein MY (2015)	1
STUB1	4	BAG2	0	pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai Q (2005), Dai Q (2005), Arndt V (2005), Arndt V (2005), Arndt V (2005), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	9
GTF2B	1	NAP1L1	2	biochemical	Wan C (2015)	1
JAK3	3	JAK2	1	affinity chromatography technology	Doucet C (2002)	1
JAK3	3	TUBA4A	1	affinity chromatography technology	Hein MY (2015)	1
JAK3	3	NMI	3	affinity chromatography technology	Hein MY (2015)	1
UHRF2	1	CDK1	0	far western blotting	Mori T (2011)	1
JAK2	1	PRMT5	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pollack BP (1999), Pollack BP (1999), Liu F (2011), Liu F (2011), Liu F (2011)	5
JAK3	3	ARAF	0	affinity chromatography technology	Hein MY (2015)	1
IRS1	7	JAK3	3	affinity chromatography technology	Johnston JA (1995)	1
JAK1	6	STAT5B	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	3
JAK3	3	CSNK1E	0	affinity chromatography technology	Hein MY (2015)	1
STAM	3	JAK3	3	affinity chromatography technology	Takeshita T (1997)	1
JAK3	3	STUB1	4	affinity chromatography technology	Hein MY (2015)	1
CCT3	1	CCT6A	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
JAK3	3	NAP1L4	3	affinity chromatography technology	So J (2015)	1
JAK3	3	UBR5	13	affinity chromatography technology	Hein MY (2015)	1
SRRM2	18	DHX16	5	affinity chromatography technology	McCracken S (2005)	1
TYK2	1	BAG2	0	affinity chromatography technology	So J (2015)	1
RAB11FIP2	2	RAB11A	4	two hybrid, two hybrid, far western blotting, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lindsay AJ (2002), Hales CM (2001), Hales CM (2001), Prekeris R (2001), Wei J (2006), Ducharme NA (2006), Nedvetsky PI (2007), Hein MY (2015), Huttlin EL (2017)	9
PTK2B	6	JAK1	6	affinity chromatography technology	Benbernou N (2000)	1
CRY1	0	PRMT5	3	affinity chromatography technology	Papp SJ (2015)	1
CRY1	0	TCP1	0	affinity chromatography technology	Papp SJ (2015)	1
JAK3	3	GPATCH8	5	affinity chromatography technology	So J (2015)	1
CD3E	0	CD247	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Munoz P (2003), Munoz P (2003), Chen TC (2014)	3
KIT	4	CD81	0	affinity chromatography technology, affinity chromatography technology	Anzai N (2002), Anzai N (2002)	2
SOCS3	0	PTK2B	6	two hybrid, affinity chromatography technology	Masuhara M (1997), Zhang S (2008)	2
JAK3	3	TNPO3	16	affinity chromatography technology	Hein MY (2015)	1
CSNK1E	0	CRY1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Wallach T (2013), Hein MY (2015), Huttlin EL (2017)	4
JAK3	3	CCT2	1	affinity chromatography technology	So J (2015)	1
JAK1	6	STAT5A	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	4
TYK2	1	CCT6A	1	affinity chromatography technology	So J (2015)	1
PTK2B	6	IL7R	2	affinity chromatography technology	Benbernou N (2000)	1
CD81	0	JAK3	3	two hybrid	Wang J (2011)	1
JAK3	3	CCT6A	1	affinity chromatography technology, affinity chromatography technology	So J (2015), Hein MY (2015)	2
KIT	4	JAK2	1	affinity chromatography technology	Brizzi MF (1994)	1
IKBKG	0	JAK2	1	pull down	Fenner BJ (2010)	1
JAK3	3	LYSMD2	2	affinity chromatography technology	Hein MY (2015)	1
CXCR4	0	JAK2	1	affinity chromatography technology	Vila-Coro AJ (1999)	1
NMI	3	STAT5A	4	pull down, two hybrid, affinity chromatography technology	Zhu M (1999), Zhu M (1999), Zhu M (1999)	3
SRRM2	18	BAG2	0	affinity chromatography technology	McCracken S (2005)	1
JAK2	1	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Kawazoe Y (2001)	2
ERBB3	3	JAK3	3	unspecified method	Jones RB (2006)	1
CCT3	1	WDR46	3	affinity chromatography technology	Huttlin EL (2017)	1
JAK2	1	NAP1L1	2	affinity chromatography technology	So J (2015)	1
JAK3	3	CCNL2	2	affinity chromatography technology	Hein MY (2015)	1
ARAF	0	TUBA4A	1	affinity chromatography technology	So J (2015)	1
JAK3	3	CCT3	1	affinity chromatography technology	So J (2015)	1
GTF2B	1	JAK3	3	two hybrid	Wang J (2011)	1
JAK3	3	MAGED2	1	affinity chromatography technology	So J (2015)	1
CCT4	2	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
LEPR	3	JAK3	3	affinity chromatography technology	Sanchez-Margalet V (2001)	1
CCT2	1	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
TCP1	0	CCT8	0	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
JAK3	3	LNX1	7	two hybrid	Grossmann A (2015)	1
UHRF2	1	JAK3	3	far western blotting	Mori T (2011)	1
TCP1	0	CCT3	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
IL7R	2	JAK3	3	affinity chromatography technology	Jahn T (2007)	1
CRY1	0	CCT4	2	affinity chromatography technology	Papp SJ (2015)	1
CCT4	2	CCT8	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2