PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ITGAV	7	PTK2	2	affinity chromatography technology, affinity chromatography technology	Lee DY (2010), Avraham HK (2003)	2
DOK1	2	SRC	2	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
FLNB	11	ITGB1	4	two hybrid, pull down	van der Flier A (2002), van der Flier A (2002)	2
PDGFRA	3	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ITGA4	4	SYK	3	affinity chromatography technology	Byron A (2012)	1
ITGAV	7	PXN	1	affinity chromatography technology	Elsegood CL (2006)	1
ITGB3	6	PDGFRA	3	affinity chromatography technology	Baron W (2002)	1
DOK1	2	ITGB3	6	pull down	Anthis NJ (2009)	1
ITGB1	4	THBS1	6	affinity chromatography technology	Ashton AW (2004)	1
SRC	2	MAPK3	4	affinity chromatography technology	Lee J (2013)	1
PXN	1	PTK2B	6	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hiregowdara D (1997), Hiregowdara D (1997), Matsuya M (1998), Matsuya M (1998), Anfosso F (2001), Ivankovic-Dikic I (2000)	6
DOK1	2	TLN1	5	pull down	Anthis NJ (2009)	1
THBS1	6	ITGB3	6	pull down, affinity chromatography technology	Lawler J (1989), Ashton AW (2004)	2
SRC	2	PDGFRB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee CW (2007), Collin G (2007), Wu CY (2008)	3
ITGA2B	2	FGG	1	unspecified method	Hantgan RR (2006)	1
PLA2G2A	1	ITGAV	7	pull down	Saegusa J (2008)	1
ITGA5	7	CIB1	2	affinity chromatography technology, affinity chromatography technology	Yamodo IH (2012), Yamodo IH (2012)	2
ITGB3	6	CIB1	2	affinity chromatography technology, affinity chromatography technology	Yamodo IH (2012), Yamodo IH (2012)	2
MAPK3	4	ITGB3	6	enzymatic study	Lin HY (2013)	1
FN1	17	FGG	1	affinity chromatography technology	Moussavi-Harami SF (2013)	1
FGA	5	ITGB3	6	unspecified method	Wierzbicka I (1997)	1
CD36	2	ITGB1	4	affinity chromatography technology	Miao WM (2001)	1
ITGB3	6	ITGAV	7	x-ray crystallography, imaging technique, affinity chromatography technology	Xiong JP (2002), Moon HE (2015), Ward CM (2000)	3
PAK4	3	ITGAV	7	affinity chromatography technology	Kesanakurti D (2012)	1
PTK2	2	SYK	3	affinity chromatography technology, affinity chromatography technology	Chung J (1997), Sada K (1997)	2
PXN	1	ITGB3	6	pull down	Pfaff M (2001)	1
AKT1	1	PTK2	2	imaging technique	Moon HE (2015)	1
MMP2	2	ITGB1	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012)	3
ITGAV	7	ILK	0	affinity chromatography technology	Hannigan GE (1996)	1
FLNA	10	FLNB	11	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Sheen VL (2002), Sheen VL (2002), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	5
FN1	17	FERMT3	4	affinity chromatography technology	Humphries JD (2009)	1
MMP2	2	PAK4	3	affinity chromatography technology, affinity chromatography technology, pull down, genetic interference	Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012)	4
PTK2	2	ITGA4	4	affinity chromatography technology	Liu S (2002)	1
MMP2	2	ITGB3	6	affinity chromatography technology	Kesanakurti D (2012)	1
SHC1	0	DOK1	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Dunant NM (2000), Dunant NM (2000), Liu BA (2012)	3
SRC	2	SYK	3	enzymatic study, affinity chromatography technology, enzymatic study	Kurosaki T (1994), Asazuma N (1997), Hirose M (2004)	3
ITGAV	7	THBS1	6	affinity chromatography technology	Ashton AW (2004)	1
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
ITGB3	6	P4HB	1	pull down	Bi S (2011)	1
TLN1	5	PTK2	2	affinity chromatography technology, pull down, affinity chromatography technology	Chen HC (1995), Chen HC (1995), Zheng C (1998)	3
ITGB3	6	PLA2G4A	1	affinity chromatography technology, affinity chromatography technology, pull down	Prevost N (2009), Prevost N (2009), Prevost N (2009)	3
FLNB	11	ITGB3	6	two hybrid	van der Flier A (2002)	1
FN1	17	VIM	0	affinity chromatography technology	Humphries JD (2009)	1
ITGB1	4	ILK	0	affinity chromatography technology, two hybrid	Hannigan GE (1996), McDonald PC (2008)	2
PDGFRB	8	SHC1	0	affinity chromatography technology, affinity chromatography technology	Yokote K (1994), Yokote K (1994)	2
SRC	2	PTK2B	6	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Keely SJ (2000), Kumar S (1999), Dikic I (1996), Dikic I (1996), Bruzzaniti A (2009)	5
ITGB1	4	ITGA5	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, pull down	Lobert VH (2010), Lobert VH (2010), Zhang H (2003), Rantala JK (2011), Havugimana PC (2012), Wan C (2015), Lee HS (2014)	7
PLA2G2A	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down	Boilard E (2003), Boilard E (2003), Boilard E (2003)	3
ILK	0	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Barry FA (2002), Delcommenne M (1998), Persad S (2001), McDonald PC (2008)	4
CDK1	0	ITGB3	6	enzymatic study	Kirk RI (2000)	1
PLA2G4A	1	MAPK3	4	affinity chromatography technology	Letsiou E (2011)	1
PTK2B	6	ITGB3	6	pull down	Pfaff M (2001)	1
FN1	17	ILK	0	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	PRKCB	4	affinity chromatography technology	Humphries JD (2009)	1
MMP2	2	ITGAV	7	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012)	4
ITGB3	6	FGG	1	unspecified method	Hantgan RR (2006)	1
FN1	17	ITGAV	7	affinity chromatography technology	Humphries JD (2009)	1
ITGB1	4	SHC1	0	affinity chromatography technology	Lee DY (2010)	1
ITGA5	7	ILK	0	affinity chromatography technology	Hannigan GE (1996)	1
CIB1	2	PTK2	2	affinity chromatography technology	Naik MU (2003)	1
MAPK3	4	ITGAV	7	enzymatic study, affinity chromatography technology	Lin HY (2013), Lin HY (2013)	2
SYK	3	PTK2B	6	affinity chromatography technology	Ganju RK (2000)	1
PTK2B	6	TLN1	5	affinity chromatography technology	Zheng C (1998)	1
ITGB1	4	PTK2	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Lin TY (2016), Lee DY (2010), Moon HE (2015)	3
ITGA2B	2	FN1	17	pull down	Kauf AC (2001)	1
PTK2	2	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hecker TP (2002), Angers-Loustau A (1999), Relou IA (2003), Messina S (2003), Lebrun P (1998), Ponnala S (2011), Grossmann A (2015), Chen TC (2014), Lee J (2013), Reiske HR (2000)	11
THBS1	6	FGA	5	pull down	Panetti TS (1999)	1
ITGB3	6	PTK2	2	pull down, affinity chromatography technology, affinity chromatography technology	Eliceiri BP (2002), Chung J (1997), Lee DY (2010)	3
FN1	17	PXN	1	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	FLNB	11	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	ITGA4	4	affinity chromatography technology	Humphries JD (2009)	1
ITGB3	6	VIM	0	affinity chromatography technology	Prevost N (2009)	1
FN1	17	CDK1	0	affinity chromatography technology	Humphries JD (2009)	1
ITGB3	6	SYK	3	affinity chromatography technology	Saci A (2000)	1
SRC	2	5175	0	affinity chromatography technology, affinity chromatography technology	Cicmil M (2000), Relou IA (2003)	2
PXN	1	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovacic-Milivojevic B (2001), Matsuya M (1998), Turner CE (1999), Liu S (2002), Liu S (2002), Mazaki Y (1997), Zheng C (1998), Brown MC (1996), Fujita H (1998), Zhang Z (1999), Wang JF (2000), Ivankovic-Dikic I (2000)	12
PDK1	1	ITGB3	6	enzymatic study	Kirk RI (2000)	1
PAK4	3	ITGB3	6	affinity chromatography technology	Kesanakurti D (2012)	1
PDGFRA	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TLN1	5	ITGB3	6	pull down, pull down, pull down, pull down, pull down	Patil S (1999), Calderwood DA (2002), Calderwood DA (2002), Anthis NJ (2009), Ulmer TS (2001)	5
ITGB1	4	TLN1	5	unspecified method, biochemical, pull down, pull down	Martel V (2001), Havugimana PC (2012), Anthis NJ (2009), Anthis NJ (2009)	4
ITGB3	6	EPHA2	3	affinity chromatography technology	Dutta D (2013)	1
AKT1	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhu QS (2011), Zhu QS (2011), Zhu QS (2011), Zhu QS (2011)	4
SYK	3	PXN	1	affinity chromatography technology	Fernandez R (1998)	1
ITGA4	4	CDK1	0	affinity chromatography technology	Byron A (2012)	1
ITGB3	6	PRKCB	4	affinity chromatography technology	Prevost N (2009)	1
PXN	1	ILK	0	pull down, affinity chromatography technology, affinity chromatography technology	Nikolopoulos SN (2001), So J (2015), Hein MY (2015)	3
PAK4	3	PXN	1	affinity chromatography technology	Dart AE (2015)	1
FN1	17	TLN1	5	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Humphries JD (2009)	2
AKT1	1	ITGB3	6	enzymatic study	Kirk RI (2000)	1
SRC	2	FLNA	10	two hybrid	Bandyopadhyay S (2010)	1
ITGB3	6	KDR	4	imaging technique, affinity chromatography technology	Koutsioumpa M (2015), Koutsioumpa M (2015)	2
CD36	2	ITGB3	6	affinity chromatography technology	Miao WM (2001)	1
ITGAV	7	ITGA4	4	imaging technique	Moon HE (2015)	1
ITGAV	7	EPHA2	3	affinity chromatography technology	Dutta D (2013)	1
ITGB3	6	PDGFRB	8	affinity chromatography technology	Borges E (2000)	1
SHC1	0	PTK2	2	affinity chromatography technology	Hecker TP (2002)	1
FN1	17	ITGB1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Humphries JD (2009), Humphries JD (2009), Kharitidi D (2015), Lee HS (2014)	4
SRC	2	PXN	1	pull down	Angers-Loustau A (1999)	1
FLNA	10	SYK	3	imaging technique	Justa-Schuch D (2016)	1
FGG	1	FGA	5	x-ray crystallography	Kostelansky MS (2002)	1
ITGB3	6	ITGB1	4	imaging technique	Moon HE (2015)	1
ITGA4	4	TLN1	5	affinity chromatography technology	Byron A (2012)	1
SHC1	0	EPHA2	3	affinity chromatography technology, pull down	Pratt RL (2002), Pratt RL (2002)	2
DOK1	2	ITGB1	4	pull down	Anthis NJ (2009)	1
SRC	2	ITGB3	6	enzymatic study	Kirk RI (2000)	1
ITGA4	4	VIM	0	affinity chromatography technology	Byron A (2012)	1
FN1	17	ITGA5	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Busk M (1992), Lobert VH (2010), Humphries JD (2009), Humphries JD (2009), Kharitidi D (2015), Lee HS (2014)	6
ITGA4	4	FERMT3	4	affinity chromatography technology	Byron A (2012)	1
FLNA	10	ITGB3	6	two hybrid	van der Flier A (2002)	1
EPHA2	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
THBS1	6	MMP2	2	two hybrid, affinity chromatography technology	Bein K (2000), Bein K (2000)	2
AKT1	1	PRKCB	4	two hybrid, enzymatic study	Arroyo R (2015), Wu D (2009)	2
ITGB3	6	ITGA4	4	imaging technique	Moon HE (2015)	1
ITGA4	4	FLNA	10	affinity chromatography technology	Byron A (2012)	1
PLA2G4A	1	VIM	0	affinity chromatography technology	Prevost N (2009)	1
PRKCB	4	CDK1	0	affinity chromatography technology	Chiarini A (2002)	1
FLNA	10	ITGB1	4	two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	van der Flier A (2002), van der Flier A (2002), Loo DT (1998), Loo DT (1998), Loo DT (1998)	5
ITGB3	6	FN1	17	pull down	Kauf AC (2001)	1
ITGB3	6	ITGB3BP	0	two hybrid, two hybrid, pull down	Fujimoto TT (2002), Shattil SJ (1995), Shattil SJ (1995)	3
ILK	0	ITGB3	6	affinity chromatography technology	Yamaji S (2002)	1
ITGAV	7	ITGB1	4	biochemical, pull down, imaging technique	Wan C (2015), Hu B (2006), Moon HE (2015)	3
ITGAV	7	SHC1	0	affinity chromatography technology	Lee DY (2010)	1
ITGA2B	2	PLA2G4A	1	pull down	Prevost N (2009)	1
ITGB3BP	0	FLNB	11	affinity chromatography technology	Hein MY (2015)	1
ITGB3	6	SHC1	0	affinity chromatography technology, unspecified method	Lee DY (2010), Kirk RI (2000)	2
ITGB3	6	ITGA5	7	affinity chromatography technology, biochemical, pull down	Wang L (2012), Wan C (2015), Vallar L (1999)	3
PXN	1	ITGB1	4	affinity chromatography technology, affinity chromatography technology	Chen LM (2000), Lin TY (2016)	2
ITGB3	6	5175	0	imaging technique	Wong CW (2000)	1
SHC1	0	SRC	2	pull down	Schueller AC (2008)	1
ITGB1	4	EPHA2	3	affinity chromatography technology	Dutta D (2013)	1
SHC1	0	KDR	4	affinity chromatography technology, affinity chromatography technology	Zanetti A (2002), DAngelo G (1999)	2
ITGA2B	2	CIB1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Naik UP (1997), Naik UP (1997), Yamodo IH (2012), Yamodo IH (2012)	4
ITGA4	4	FLNB	11	affinity chromatography technology	Byron A (2012)	1
PTK2	2	EPHA2	3	affinity chromatography technology	Miao H (2000)	1
PLA2G2A	1	ITGB3	6	pull down	Saegusa J (2008)	1
PXN	1	ITGA4	4	pull down, pull down	Han J (2001), Liu S (2002)	2
CD36	2	ITGA2B	2	affinity chromatography technology	Miao WM (2001)	1
PXN	1	TLN1	5	pull down, pull down, affinity chromatography technology	Mazaki Y (1997), Salgia R (1995), Salgia R (1996)	3
TLN1	5	ITGA5	7	imaging technique	Lilja J (2017)	1
ITGA2B	2	ITGB3	6	pull down, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yin H (2006), Wang R (1997), Wang R (1997), Ulmer TS (2001), Ulmer TS (2001), Afrasiabi A (2008), Rosenberg N (2004), Vallar L (1999), Ward CM (2000)	9
FN1	17	FLNA	10	affinity chromatography technology	Humphries JD (2009)	1
MMP2	2	FN1	17	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	TLN1	5	affinity chromatography technology	Lee J (2013)	1
FERMT3	4	ITGB3	6	affinity chromatography technology, imaging technique	Bialkowska K (2015), Bialkowska K (2015)	2
PDGFRA	3	PDGFRB	8	affinity chromatography technology, pull down, affinity chromatography technology	Rupp E (1994), Seifert RA (1989), Huttlin EL (2017)	3
FN1	17	FGA	5	affinity chromatography technology	Moussavi-Harami SF (2013)	1
FGA	5	ITGA2B	2	unspecified method	Wierzbicka I (1997)	1
ILK	0	SHC1	0	two hybrid	Vinayagam A (2011)	1
SRC	2	KDR	4	affinity chromatography technology, affinity chromatography technology, unspecified method	Meyer RD (2008), Gavard J (2008), Sun Z (2012)	3