PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ERBB2	6	JAK2	1	affinity chromatography technology	Ren Z (2002)	1
PTPN11	20	JAK1	6	pull down, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Lehmann U (2003)	3
IRS2	6	DVL2	5	affinity chromatography technology, affinity chromatography technology	Geng Y (2014), Geng Y (2014)	2
INSR	9	JAK1	6	affinity chromatography technology	Le MN (2002)	1
JAK2	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Olayioye MA (1999), Olayioye MA (1999), Jones RB (2006), He K (2013)	4
PTK2	2	JAK2	1	affinity chromatography technology, affinity chromatography technology	Zhu T (1998), Ryu H (2000)	2
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
PIK3R2	3	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Kuchay S (2013), Hein MY (2015)	3
PIK3R1	6	IRS1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology	Hadari YR (1992), Morrison KB (2002), Gual P (2003), Hamer I (2002), Bazuine M (2003), Tzatsos A (2006), Calegari VC (2005), Tzatsos A (2009), Liu BA (2012), Sung CK (1994), Ren W (2013), Sung CK (1998), Grossmann A (2015), Grossmann A (2015), Antonetti DA (1996), Luo M (2007), Luo M (2007)	17
IRS1	7	APP	1	pull down	Olah J (2011)	1
IRS1	7	UBTF	8	affinity chromatography technology, affinity chromatography technology	Sun H (2003), Dalmizrak O (2007)	2
PIK3R1	6	PIK3CA	8	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017)	9
PELI1	1	UBC	7	enzymatic study, enzymatic study	Smith H (2009), Smith H (2011)	2
IKBKB	1	PRKCD	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	4
IRS1	7	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Zhang J (2007), Froejdoe S (2011)	2
ERBB2	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Vogel W (1996)	5
SMAD3	1	IRS1	7	affinity chromatography technology	Brown KA (2008)	1
MAPK8	3	SIRT1	3	affinity chromatography technology, enzymatic study	Nasrin N (2009), Nasrin N (2009)	2
HDAC2	1	ESR1	0	affinity chromatography technology, affinity chromatography technology	Itoh Y (2007), Tarallo R (2011)	2
GRB2	2	KHDRBS1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, two hybrid	Liu SK (1998), Oneyama C (2002), Shen Z (1999), Shen Z (1999), Bandyopadhyay S (2010), Asbach B (2012), Bisson N (2011), Wang J (2011)	8
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
FBXW8	2	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Huber C (2005), Huber C (2005), Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Skaar JR (2007), Skaar JR (2007), Tsutsumi T (2008), Kong C (2012), Xu X (2012), Xu X (2008), Xu X (2008)	13
BCAR3	5	APP	1	pull down	Olah J (2011)	1
NCK2	2	PTK2	2	pull down, affinity chromatography technology	Goicoechea SM (2002), Goicoechea SM (2002)	2
PTPN1	2	GRB2	2	pull down, pull down, affinity chromatography technology	Goldstein BJ (2000), Liu F (1996), Li X (2016)	3
IRS2	6	JAK1	6	affinity chromatography technology	Johnston JA (1995)	1
GRB10	4	JAK2	1	affinity chromatography technology	Moutoussamy S (1998)	1
IRS1	7	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
PIK3CA	8	SMAD3	1	pull down	Richard KC (2006)	1
FBXO25	1	EGFR	5	enzymatic study	Teixeira FR (2013)	1
ESR1	0	PIK3R2	3	affinity chromatography technology	Cabodi S (2004)	1
ESR1	0	SFN	1	affinity chromatography technology	Tarallo R (2011)	1
RPTOR	4	IRS1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tzatsos A (2006), Tzatsos A (2009), Tzatsos A (2009), Tzatsos A (2009)	4
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
ESR1	0	KHDRBS1	1	affinity chromatography technology	Tarallo R (2011)	1
UBC	7	NCK2	2	unspecified method, x-ray crystallography	Kang J (2008), Kang J (2008)	2
NCK2	2	ERBB2	6	unspecified method	Jones RB (2006)	1
INSR	9	SH2B1	7	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Kotani K (1998), Kotani K (1998), Nelms K (1999), Nelms K (1999), Nishi M (2005)	5
INSR	9	PTPN11	20	pull down, affinity chromatography technology, pull down	Maegawa H (1994), Kharitonenkov A (1995), Kharitonenkov A (1995)	3
KHDRBS1	1	NCK2	2	unspecified method	Asbach B (2012)	1
NCK2	2	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Chen M (1998), Braverman LE (1999), Tu Y (1998), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
AKT1	1	SFN	1	affinity chromatography technology, affinity chromatography technology	Calvo N (2010), Calvo N (2010)	2
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
EGFR	5	YWHAB	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CBL	7	PIK3CB	2	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Momose H (2003)	2
IRS1	7	SH2B1	7	unspecified method	Liu BA (2012)	1
IKBKB	1	PELI1	1	enzymatic study	Smith H (2011)	1
CBLB	3	PLCG2	11	affinity chromatography technology	Yasuda T (2002)	1
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
PIK3R3	0	PTK2	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
MAPK3	4	RPTOR	4	enzymatic study, pull down	Carriere A (2011), Carriere A (2011)	2
ALK	8	JAK3	3	affinity chromatography technology, affinity chromatography technology	Zamo A (2002), Crockett DK (2004)	2
IRS1	7	FBXW8	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Xu X (2012), Xu X (2008), Xu X (2008), Xu X (2008), Xu X (2008), Xu X (2008)	6
IRS1	7	PLCG2	11	unspecified method	Liu BA (2012)	1
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
AKT1	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Xiong Y (2009), Xiong Y (2009), Ivanov AA (2017)	3
INSR	9	PRKCD	2	affinity chromatography technology, affinity chromatography technology	Braiman L (2001), Rosenzweig T (2002)	2
AKT1	1	PTK2	2	imaging technique	Moon HE (2015)	1
GRB10	4	YWHAE	0	pull down, affinity chromatography technology, affinity chromatography technology	Urschel S (2005), Urschel S (2005), Urschel S (2005)	3
MAPK8	3	BCL2	0	enzymatic study	Kang CB (2005)	1
GRB2	2	PIK3CB	2	affinity chromatography technology, affinity chromatography technology	Bisson N (2011), Huttlin EL (2017)	2
EGLN3	0	RPTOR	4	affinity chromatography technology	Rodriguez J (2016)	1
INSR	9	KHDRBS1	1	affinity chromatography technology	Sanchez-Margalet V (2001)	1
EGLN3	0	NISCH	11	affinity chromatography technology	Rodriguez J (2016)	1
IRS1	7	CBLB	3	affinity chromatography technology	Suzue N (2006)	1
IRS2	6	GRB2	2	unspecified method, affinity chromatography technology	Liu BA (2012), Bisson N (2011)	2
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
RPTOR	4	RPS6KB1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Ali SM (2005), Ha SH (2006), Hara K (2002), Nojima H (2003), Kwak D (2012), Carriere A (2011), Ha SH (2006), Li L (2013), Garcia-Martinez JM (2009)	9
IRS2	6	UBTF	8	affinity chromatography technology	Sun H (2003)	1
EGFR	5	PIK3R2	3	affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, protein complementation assay	Tong J (2009), Jones RB (2006), Foerster S (2013), Kotlyar M (2015), Gout I (1992), Petschnigg J (2014)	6
GRB10	4	APP	1	pull down	Olah J (2011)	1
EGFR	5	SH2B1	7	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
NUMB	1	APP	1	pull down, imaging technique	Olah J (2011), Chen TC (2014)	2
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
EGFR	5	IRS1	7	unspecified method	Jones RB (2006)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
MAPK8	3	BCL2L1	0	imaging technique, enzymatic study	Chen TC (2014), Wang J (2012)	2
IRS1	7	HDAC2	1	two hybrid, pull down, affinity chromatography technology	Kaiser C (2004), Kaiser C (2004), Kaiser C (2004)	3
YWHAE	0	IGF1R	5	two hybrid, pull down	Craparo A (1997), Craparo A (1997)	2
SIRT1	3	MTOR	14	affinity chromatography technology, affinity chromatography technology	Back JH (2011), Singh BK (2016)	2
PIK3R2	3	PTPN11	20	affinity chromatography technology	Brehme M (2009)	1
CBLB	3	PTPN11	20	affinity chromatography technology	Hoff H (2007)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
GRB10	4	EGFR	5	pull down, two hybrid, protein complementation assay	He W (1998), Kotlyar M (2015), Petschnigg J (2014)	3
YWHAH	0	IRS2	6	affinity chromatography technology	Hein MY (2015)	1
PIK3R1	6	JAK2	1	pull down, genetic interference	Ren SY (2005), Shen JP (2017)	2
ALK	8	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Crockett DK (2004), Crockett DK (2004), Bai RY (1998), Ambrogio C (2005), Ambrogio C (2005)	5
PTK2	2	IRS1	7	two hybrid, affinity chromatography technology	Lebrun P (1998), Lebrun P (1998)	2
IRS1	7	PIK3R3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Xia X (1999), Mothe I (1997), Grossmann A (2015), Grossmann A (2015)	4
NCK2	2	IRS1	7	pull down	Tu Y (1998)	1
YWHAE	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian RR (2001), Taipale M (2014), Taipale M (2014)	3
EGLN3	0	CHUK	5	affinity chromatography technology	Fu J (2013)	1
IKBKB	1	IRS1	7	affinity chromatography technology	Gao Z (2002)	1
SIRT1	3	JAK1	6	affinity chromatography technology	Lin Z (2012)	1
EGLN3	0	YWHAE	0	affinity chromatography technology	Rodriguez J (2016)	1
CUL7	4	UBTF	8	affinity chromatography technology	Hanson D (2014)	1
SH2B1	7	GRB2	2	affinity chromatography technology, pull down	Qian X (1998), Kotani K (1998)	2
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
CHUK	5	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
NISCH	11	IRS2	6	affinity chromatography technology	Sano H (2002)	1
JAK3	3	SOCS3	0	affinity chromatography technology	Cho-Vega JH (2004)	1
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
PIK3R1	6	GRB10	4	affinity chromatography technology	Deng Y (2003)	1
INSR	9	JAK2	1	affinity chromatography technology, affinity chromatography technology	Maegawa H (1996), Le MN (2002)	2
EGLN3	0	PIK3R2	3	affinity chromatography technology	Rodriguez J (2016)	1
CUL7	4	APP	1	affinity chromatography technology	Hanson D (2014)	1
YWHAE	0	IRS2	6	affinity chromatography technology	Gloeckner CJ (2007)	1
IRS1	7	PELI1	1	two hybrid	Grossmann A (2015)	1
MAPK8	3	RPTOR	4	affinity chromatography technology, affinity chromatography technology	Kwak D (2012), Kwak D (2012)	2
NCK2	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buvall L (2013), Buvall L (2013), Huttlin EL (2015), Huttlin EL (2017)	4
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
PTPN11	20	IRS1	7	pull down, affinity chromatography technology, unspecified method, pull down, enzymatic study	Kuhne MR (1993), Myers MG (1998), Liu BA (2012), Strack V (2002), Strack V (2002)	5
IGF1R	5	PTPN1	2	affinity chromatography technology	Bandyopadhyay D (1997)	1
NISCH	11	PIK3R1	6	affinity chromatography technology	Boldt K (2016)	1
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
YWHAB	1	PIK3R2	3	affinity chromatography technology	Jin J (2004)	1
PRKCD	2	MTOR	14	affinity chromatography technology, affinity chromatography technology	Kumar V (2000), Kumar V (2000)	2
IRS1	7	PIK3CB	2	affinity chromatography technology	Kuchay S (2013)	1
FBXO25	1	IRS1	7	enzymatic study	Teixeira FR (2013)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
IRS2	6	SIRT1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang J (2007), Zhang J (2007), Froejdoe S (2011)	3
RPS6KB1	1	APP	1	pull down	Olah J (2011)	1
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
SIRT1	3	DVL2	5	affinity chromatography technology, affinity chromatography technology	Holloway KR (2010), Holloway KR (2010)	2
NISCH	11	IRS1	7	affinity chromatography technology	Sano H (2002)	1
AKT1	1	PIK3CB	2	biochemical	Wan C (2015)	1
SOCS1	1	ERBB2	6	unspecified method	Jones RB (2006)	1
ESR1	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Castoria G (2001), Simoncini T (2000), Simoncini T (2000)	3
SH2B1	7	IGF1R	5	two hybrid	Nishi M (2005)	1
PIK3R3	0	NISCH	11	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	NISCH	11	affinity chromatography technology	Bisson N (2011)	1
CHUK	5	ESR1	0	imaging technique	Park KJ (2005)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
YWHAB	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
SOCS1	1	IRS2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rui L (2002), Rui L (2002), McCormick SM (2016), McCormick SM (2016)	4
IRS2	6	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Argetsinger LS (1996), Verdier F (1997), Kim B (1998), Hamer I (2002), Calegari VC (2005), Tzatsos A (2009), Ren W (2013), Hein MY (2015)	8
GRB2	2	YWHAB	1	affinity chromatography technology	Bisson N (2011)	1
ESR1	0	IRS1	7	affinity chromatography technology, affinity chromatography technology	Morelli C (2003), Morelli C (2003)	2
GRB10	4	NEDD4	2	affinity chromatography technology	Murdaca J (2004)	1
IRS2	6	PTPN11	20	affinity chromatography technology	Argetsinger LS (1996)	1
NEDD4	2	IRS2	6	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down	Fukushima T (2015), Fukushima T (2015), Fukushima T (2015), Fukushima T (2015), Fukushima T (2015)	5
RPTOR	4	ESR1	0	affinity chromatography technology, affinity chromatography technology	Alayev A (2016), Alayev A (2016)	2
PTPN1	2	JAK2	1	affinity chromatography technology, enzymatic study	Myers MP (2001), Lund IK (2005)	2
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
SOCS1	1	PIK3R1	6	two hybrid	Grossmann A (2015)	1
IGF1R	5	APP	1	pull down	Olah J (2011)	1
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
PTPN1	2	IRS1	7	pull down, affinity chromatography technology	Goldstein BJ (2000), Ravichandran LV (2001)	2
SIRT1	3	RPTOR	4	affinity chromatography technology, affinity chromatography technology	Back JH (2011), Back JH (2011)	2
IGF1R	5	PIK3R1	6	imaging technique	Chen TC (2014)	1
INSR	9	GRB2	2	affinity chromatography technology	Ishihara H (1997)	1
BCL2	0	IRS2	6	affinity chromatography technology	Ueno H (2000)	1
PTK2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Manes S (1999), Takahashi A (2011)	2
NEDD4	2	CBLB	3	pull down, affinity chromatography technology, affinity chromatography technology	Magnifico A (2003), Magnifico A (2003), Magnifico A (2003)	3
CBL	7	IRS1	7	affinity chromatography technology	Ahmed Z (2000)	1
IRS1	7	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Skolnik EY (1993), Skolnik EY (1993), Skolnik EY (1993), Morrison KB (2002), Giorgetti-Peraldi S (1995), Liu BA (2012), Bisson N (2011)	7
EGLN3	0	IRS2	6	affinity chromatography technology	Rodriguez J (2016)	1
PTPRU	7	IRS1	7	enzymatic study	Strack V (2002)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
PIK3R2	3	PIK3CB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
IRS1	7	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Sung CK (1994)	2
CUL7	4	KHDRBS1	1	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	UBC	7	affinity chromatography technology	Hanson D (2014)	1
IGF1R	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Manes S (1999), Seely BL (1995), Seely BL (1995), Yao Z (2017)	4
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
YWHAB	1	IGF1R	5	pull down	Furlanetto RW (1997)	1
YWHAH	0	IRS1	7	affinity chromatography technology	Ichimura T (2002)	1
MAPK8	3	AKT1	1	enzymatic study	Xiao L (2010)	1
PIK3R2	3	APP	1	pull down	Olah J (2011)	1
SMAD3	1	APP	1	pull down	Olah J (2011)	1
BCL2L1	0	MTOR	14	affinity chromatography technology, enzymatic study	Ramanathan A (2009), Ramanathan A (2009)	2
IGF1R	5	MTOR	14	genetic interference	Shen JP (2017)	1
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
IRS1	7	ALK	8	affinity chromatography technology	Crockett DK (2004)	1
CBL	7	ERBB2	6	pull down, affinity chromatography technology	Zhou P (2003), Bisaro B (2016)	2
MAPK8	3	IRS1	7	two hybrid, affinity chromatography technology, pull down	Aguirre V (2002), Aguirre V (2000), Aguirre V (2000)	3
EGFR	5	SOCS3	0	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Xia L (2002), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
YWHAB	1	IRS2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004), Couzens AL (2013)	3
IRS2	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
PTK2	2	ERBB2	6	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Ritch PA (2003), Ritch PA (2003)	3
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
EGFR	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology, enzymatic study	Schulze WX (2006), Tomic S (1995), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Kapoor GS (2010), Vogel W (1996)	7
BCL2	0	CHUK	5	affinity chromatography technology	Bodur C (2012)	1
PIK3R3	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
IGF1R	5	NEDD4	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Vecchione A (2003), Sehat B (2008), Broussas M (2009)	3
CBLB	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Ettenberg SA (1999), Lavagna-Sevenier C (1998), Lavagna-Sevenier C (1998), Elly C (1999), Bandyopadhyay S (2010), Vinayagam A (2011), Bisson N (2011), Blagoev B (2003), Rolland T (2014), Huttlin EL (2017)	10
JAK1	6	SOCS1	1	affinity chromatography technology	Park ES (2000)	1
PIK3R1	6	ALK	8	pull down	Ren SY (2005)	1
MAPK3	4	UBTF	8	enzymatic study	Stefanovsky VY (2001)	1
PTK2	2	SOCS3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Le Y (2007), Le Y (2007), Niwa Y (2005), Rolland T (2014)	4
GRB10	4	IGF1R	5	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Vecchione A (2003), Vecchione A (2003), Dey BR (1996), He W (1998), Morrione A (1996), Morrione A (1996), Broussas M (2009)	7
CBLB	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavagna-Sevenier C (1998), Elly C (1999), Elly C (1999), Alcazar I (2009), Fang D (2001)	5
RPS6KB1	1	AKT1	1	biochemical, imaging technique	Berven LA (2004), Chen TC (2014)	2
YWHAE	0	IRS1	7	pull down, two hybrid	Craparo A (1997), Craparo A (1997)	2
INSR	9	IRS1	7	two hybrid, two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Aguirre V (2002), Sawka-Verhelle D (1996), Strack V (2002), Wolf G (1995), Kwon H (2015), Kwon H (2015)	6
SMAD3	1	CHUK	5	affinity chromatography technology	Descargues P (2008)	1
ALK	8	PIK3CB	2	affinity chromatography technology	Crockett DK (2004)	1
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
AKT1	1	RPTOR	4	affinity chromatography technology	Kim EK (2011)	1
JAK1	6	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Johnston JA (1995)	2
CBLB	3	PIK3R2	3	affinity chromatography technology	Alcazar I (2009)	1
IGF1R	5	PTK2	2	affinity chromatography technology	Manes S (1999)	1
PTPRU	7	EGFR	5	enzymatic study	Crossland S (1996)	1
GRB10	4	AKT1	1	pull down, enzymatic study	Urschel S (2005), Urschel S (2005)	2
GRB2	2	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid	Sieg DJ (2000), Angers-Loustau A (1999), Hildebrand JD (1996), Messina S (2003), Arold ST (2002), Vinayagam A (2011)	6
ERBB2	6	PTPRU	7	two hybrid	Yao Z (2017)	1
CHUK	5	PRKCD	2	pull down, affinity chromatography technology, affinity chromatography technology	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	3
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
ERBB2	6	PIK3R3	0	unspecified method	Jones RB (2006)	1
PTK2	2	EGFR	5	affinity chromatography technology, two hybrid, protein complementation assay	Sieg DJ (2000), Kotlyar M (2015), Petschnigg J (2014)	3
EGFR	5	PLCG2	11	unspecified method, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Petschnigg J (2014)	5
RPS6KB1	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chiang GG (2005), Holz MK (2005), Holz MK (2005), Hara K (2002), Isotani S (1999), Long X (2005), Toral-Barza L (2005), Ali SM (2005), Saitoh M (2002), Kim DH (2002), Edinger AL (2003), Leone M (2006), Takahashi T (2000), Burnett PE (1998), Sarbassov DD (2005), Agrawal P (2012), Sancak Y (2007), Oshiro N (2004), Sarbassov DD (2005), Kim DH (2003), Kim DH (2003), Nojima H (2003), Martin J (2008), Wing LY (2005), Ren HY (2015)	25
SFN	1	IRS1	7	affinity chromatography technology	Benzinger A (2005)	1
PIK3R2	3	PIK3R3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
IRS1	7	IRS2	6	biochemical	Sun H (2003)	1
GRB2	2	YWHAE	0	affinity chromatography technology	Bisson N (2011)	1
INSR	9	IRS2	6	two hybrid	Sawka-Verhelle D (1996)	1
RPS6KB1	1	IRS1	7	enzymatic study, pull down, enzymatic study	Xu X (2012), Xu X (2012), Xu X (2008)	3
ALK	8	SOCS1	1	affinity chromatography technology	Crockett DK (2004)	1
PRKCD	2	APP	1	pull down	Olah J (2011)	1
ALK	8	JAK2	1	affinity chromatography technology	Crockett DK (2004)	1
PIK3CB	2	PRKCD	2	affinity chromatography technology	Stetak A (2001)	1
PIK3R3	0	PIK3CA	8	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Mothe I (1997), Grossmann A (2015), Hein MY (2015), Huttlin EL (2017)	4
PTK2	2	APP	1	pull down	Olah J (2011)	1
IRS1	7	DVL2	5	affinity chromatography technology, affinity chromatography technology	Geng Y (2014), Geng Y (2014)	2
JAK3	3	JAK1	6	affinity chromatography technology	Doucet C (2002)	1
CBL	7	IGF1R	5	enzymatic study, affinity chromatography technology	Sehat B (2008), Sehat B (2008)	2
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
JAK2	1	SOCS1	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yasukawa H (1999), Dif F (2001), Endo TA (1997), Endo TA (1997), Endo TA (1997), Yasukawa H (1999), Yasukawa H (1999), Pezet A (1999), Ungureanu D (2002), Masuhara M (1997), Ali S (2003), Monni R (2001), Monni R (2001), Piessevaux J (2008), Yu L (2009), Maruoka M (2017)	16
AKT1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Vandermoere F (2005), Vandermoere F (2005), Chen TC (2014), Busch F (2012)	4
IRS2	6	RPTOR	4	pull down	Tzatsos A (2009)	1
YWHAB	1	APP	1	pull down	Olah J (2011)	1
RPTOR	4	CHUK	5	affinity chromatography technology	Dan HC (2008)	1
INSR	9	SOCS1	1	affinity chromatography technology	Mooney RA (2001)	1
AP3S1	0	IRS1	7	pull down	VanRenterghem B (1998)	1
PIK3CA	8	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sattler M (1997), Sattler M (1997), Chernock RD (2001), Chernock RD (2001), Brehme M (2009)	5
MAPK8	3	RPS6KB1	1	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Zhang J (2013), Zhang J (2013), Zhang J (2013)	4
MTOR	14	ESR1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Alayev A (2016), Alayev A (2016), Alayev A (2016)	3
JAK3	3	JAK2	1	affinity chromatography technology	Doucet C (2002)	1
ESR1	0	UBTF	8	affinity chromatography technology	Tarallo R (2011)	1
IRS1	7	MTOR	14	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ozes ON (2001), Tzatsos A (2006), Tzatsos A (2006)	3
PLCG2	11	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Boudot C (2002), Boudot C (2002)	2
CBL	7	PTK2	2	imaging technique, affinity chromatography technology, affinity chromatography technology	Rafiq K (2011), Schmidt MH (2003), Sekine Y (2007)	3
EGFR	5	AP3S1	0	affinity chromatography technology	Tong J (2014)	1
IGF1R	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Santen RJ (2005), Song RX (2004), Yoshimaru T (2013)	3
IRS1	7	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tzatsos A (2006), Bazuine M (2003), Whiteman EL (2003), Kuchay S (2013)	4
UBC	7	KHDRBS1	1	pull down	Zhang X (2017)	1
PTK2	2	PIK3R1	6	affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guinebault C (1995), Guinebault C (1995), Lee DY (2010), Reddy MA (2000), Reiske HR (2000)	5
BCL2	0	IKBKB	1	affinity chromatography technology	Bodur C (2012)	1
EGFR	5	PIK3CB	2	affinity chromatography technology	Foerster S (2013)	1
AKT1	1	CHUK	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ozes ON (1999), Ozes ON (1999), Romashkova JA (1999), Lu Y (2005), Chen TC (2014), Takada Y (2005), Koul D (2001)	7
IRS2	6	RPS6KB1	1	affinity chromatography technology	Warren KJ (2016)	1
BCL2	0	IRS1	7	affinity chromatography technology, affinity chromatography technology	Ueno H (2000), Ueno H (2000)	2
AKT1	1	APP	1	pull down	Olah J (2011)	1
IRS1	7	JAK3	3	affinity chromatography technology	Johnston JA (1995)	1
IKBKB	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
IRS1	7	BCL2L1	0	affinity chromatography technology	Ueno H (2000)	1
PIK3CB	2	PIK3R1	6	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique	Hu P (1994), Havugimana PC (2012), Sun M (2010), Wan C (2015), Hein MY (2015), Chen TC (2014)	6
SOCS3	0	IGF1R	5	pull down, two hybrid, affinity chromatography technology	Dey BR (2000), Dey BR (2000), Dey BR (2000)	3
AKT1	1	BCL2L1	0	enzymatic study	Qi XJ (2006)	1
NEDD4	2	RPS6KB1	1	enzymatic study	Persaud A (2009)	1
GRB10	4	INSR	9	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Langlais P (2000), Hansen H (1996), Hansen H (1996), Hansen H (1996), Liu F (1995), Liu F (1995), Liu F (1995), He W (1998), He W (1998), Frantz JD (1997), Mori K (2005)	11
YWHAH	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian RR (2001), Taipale M (2014), Taipale M (2014)	3
RPTOR	4	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Dan HC (2008), Xu Y (2013)	2
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
AKT1	1	YWHAE	0	affinity chromatography technology	Klein JB (2005)	1
CUL7	4	HDAC2	1	affinity chromatography technology	Hanson D (2014)	1
IGF1R	5	PIK3R3	0	pull down, affinity chromatography technology, imaging technique	Mothe I (1997), Mothe I (1997), Chen TC (2014)	3
CBL	7	YWHAB	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Robertson H (1997), Robertson H (1997), Robertson H (1997), Subramanian RR (2001), Chernock RD (2001), Brehme M (2009), Couzens AL (2013)	7
ESR1	0	ERBB2	6	affinity chromatography technology	Yang Z (2004)	1
PIK3R1	6	KHDRBS1	1	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Shen Z (1999), Shen Z (1999), Asbach B (2012), Asbach B (2012), Asbach B (2012), Sung CK (1994), Sung CK (1994)	8
ERBB2	6	PLCG2	11	unspecified method, imaging technique	Jones RB (2006), Chen TC (2014)	2
IRS1	7	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Rui L (2002), Li JY (2007)	2
IRS2	6	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Whiteman EL (2003), Fukushima T (2015)	2
IGF1R	5	ERBB2	6	affinity chromatography technology	Riedemann J (2007)	1
INSR	9	SOCS3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Senn JJ (2003), Calegari VC (2005), Calegari VC (2005)	3
EGFR	5	CBLB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Schulze WX (2006), Ettenberg SA (1999), Davies GC (2006), Davies GC (2006), Tong J (2009), Ettenberg SA (2001), Tong J (2008), Levkowitz G (1999), Tong J (2014)	9
EGFR	5	SFN	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Li J (2013)	5
EGLN3	0	PTPN1	2	affinity chromatography technology	Rodriguez J (2016)	1
PTPN1	2	EGFR	5	x-ray crystallography, enzymatic study, two hybrid, protein complementation assay, affinity chromatography technology, pull down, pull down	Sarmiento M (2000), Zhang ZY (1996), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Milarski KL (1993), Milarski KL (1993)	7
ERBB2	6	IRS1	7	unspecified method	Jones RB (2006)	1
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
SFN	1	IRS2	6	affinity chromatography technology	Benzinger A (2005)	1
CUL7	4	YWHAE	0	affinity chromatography technology	Hanson D (2014)	1
PIK3R1	6	PLCG2	11	imaging technique	Chen TC (2014)	1
EGLN3	0	SIRT1	3	affinity chromatography technology	Rodriguez J (2016)	1
SIRT1	3	ESR1	0	affinity chromatography technology	Elangovan S (2011)	1
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
PRKCD	2	IRS1	7	affinity chromatography technology, enzymatic study	Rosenzweig T (2002), del Rincon SV (2004)	2
CBL	7	MAPK8	3	affinity chromatography technology, enzymatic study	Miao H (2002), Miao H (2002)	2
AKT1	1	MTOR	14	pull down, unspecified method, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, imaging technique	Sekulic A (2000), Cheng SW (2004), Oh WJ (2010), Sarbassov DD (2005), Ikenoue T (2008), Murata H (2011), Martin J (2008), Facchinetti V (2008), Facchinetti V (2008), Chen CH (2011), Xu Y (2013), Glidden EJ (2012), Chen TC (2014), Pitre A (2012), Moon HE (2015)	15
IRS2	6	MTOR	14	affinity chromatography technology	Warren KJ (2016)	1
CBL	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Kang JM (2012), Kang JM (2012)	2
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
IKBKB	1	EGLN3	0	affinity chromatography technology, pull down, affinity chromatography technology	Xue J (2010), Xue J (2010), Fu J (2013)	3
EGLN3	0	IRS1	7	affinity chromatography technology	Rodriguez J (2016)	1
ESR1	0	IRS2	6	affinity chromatography technology, affinity chromatography technology	Morelli C (2003), Morelli C (2003)	2
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
IRS1	7	PIK3R2	3	affinity chromatography technology	Kuchay S (2013)	1
SIRT1	3	HDAC2	1	affinity chromatography technology	Law IK (2009)	1
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
IRS2	6	PIK3R3	0	affinity chromatography technology, affinity chromatography technology	Xia X (1999), Huttlin EL (2017)	2
EGLN3	0	NUMB	1	affinity chromatography technology	Rodriguez J (2016)	1
IRS1	7	BCAR3	5	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
CBLB	3	NCK2	2	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
EGLN3	0	DVL2	5	affinity chromatography technology	Rodriguez J (2016)	1
CUL7	4	YWHAB	1	affinity chromatography technology	Hanson D (2014)	1
ERBB2	6	PIK3R2	3	pull down, unspecified method	Gout I (1992), Jones RB (2006)	2
SOCS3	0	APP	1	pull down	Olah J (2011)	1
ERBB2	6	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SFN	1	CBL	7	affinity chromatography technology	Subramanian RR (2001)	1
GRB10	4	IRS1	7	pull down, affinity chromatography technology	Hansen H (1996), Deng Y (2003)	2
SIRT1	3	PIK3R1	6	affinity chromatography technology	Froejdoe S (2011)	1
IRS1	7	AKT1	1	affinity chromatography technology, enzymatic study	Paz K (1999), Luo M (2007)	2
IRS1	7	NUMB	1	two hybrid	Grossmann A (2015)	1
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
JAK2	1	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Kawazoe Y (2001)	2
IRS1	7	UBC	7	pull down	Xu X (2012)	1
ESR1	0	PIK3CA	8	affinity chromatography technology, affinity chromatography technology	Simoncini T (2000), Yoshimaru T (2013)	2
SIRT1	3	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sundaresan NR (2011), Sundaresan NR (2011), Sundaresan NR (2011)	3
PTPN1	2	INSR	9	affinity chromatography technology	Bereziat V (2002)	1
ERBB2	6	JAK1	6	unspecified method	Jones RB (2006)	1
JAK1	6	IGF1R	5	pull down	Gual P (1998)	1
PIK3CA	8	EGFR	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAB	1	IRS1	7	pull down	Kosaki A (1998)	1
MAPK8	3	MTOR	14	affinity chromatography technology	Kwak D (2012)	1
EGFR	5	IRS2	6	affinity chromatography technology	Tong J (2008)	1
EGFR	5	MAPK8	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
MAPK3	4	IRS1	7	enzymatic study	Luo M (2007)	1
GRB10	4	IRS2	6	affinity chromatography technology, affinity chromatography technology	Deng Y (2003), Warren KJ (2016)	2
PIK3CA	8	AKT1	1	affinity chromatography technology, protein complementation assay, affinity chromatography technology, enzymatic study	Mitra S (2011), Miao B (2010), Xiong Y (2009), Akil H (2015)	4
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
EGLN3	0	CBL	7	affinity chromatography technology	Rodriguez J (2016)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
ERBB2	6	BCAR3	5	unspecified method	Jones RB (2006)	1
UBC	7	CBLB	3	pull down, pull down, pull down, pull down, enzymatic study	De Schutter J (2009), Fenner BJ (2009), Zhou ZR (2008), Raasi S (2005), Kim M (2004)	5
UBTF	8	PIK3CA	8	affinity chromatography technology	Dalmizrak O (2007)	1
CUL7	4	IRS1	7	affinity chromatography technology	Xu X (2008)	1
NEDD4	2	IRS1	7	pull down	Persaud A (2009)	1
YWHAH	0	PIK3CA	8	affinity chromatography technology	Ichimura T (2002)	1
EGLN3	0	PIK3R3	0	affinity chromatography technology	Rodriguez J (2016)	1
PIK3R3	0	PIK3CB	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Huttlin EL (2017)	2
MAPK3	4	INSR	9	affinity chromatography technology	Lin YL (2000)	1
KHDRBS1	1	PIK3R3	0	two hybrid	Wang J (2011)	1
SFN	1	YWHAB	1	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	PIK3R3	0	affinity chromatography technology	Bisson N (2011)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
EGFR	5	SOCS1	1	affinity chromatography technology	Xia L (2002)	1
ERBB2	6	PIK3R1	6	affinity chromatography technology, unspecified method	Crovello CS (1998), Jones RB (2006)	2
GRB2	2	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	3
EGFR	5	MTOR	14	affinity chromatography technology	Foerster S (2013)	1
MAPK8	3	SMAD3	1	imaging technique	Chen TC (2014)	1
EGFR	5	NUMB	1	unspecified method	Jones RB (2006)	1
SOCS1	1	PTPN11	20	affinity chromatography technology	Ali S (2003)	1
JAK2	1	SH2B1	7	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rui L (1997), Rui L (1997), Rui L (1997), Xie S (2002), Li Z (2007), Nishi M (2005), Nishi M (2005)	7
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
EGFR	5	JAK1	6	affinity chromatography technology	Tong J (2008)	1
IGF1R	5	IRS1	7	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Tartare-Deckert S (1995), Dey BR (1996), Dey BR (1996), Manes S (1999)	4
GRB2	2	YWHAH	0	affinity chromatography technology	Bisson N (2011)	1
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
CBL	7	PIK3R3	0	two hybrid, two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015), Grossmann A (2015)	3
SOCS1	1	IGF1R	5	two hybrid	Dey BR (1998)	1
CHUK	5	IRS1	7	affinity chromatography technology	Gao Z (2002)	1
SMAD3	1	NEDD4	2	affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011)	6