Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
IRS1	3667	INOSITOL	CHEMBL1222251		NCI	9693122
IRS1	3667	ALCOHOL	CHEMBL545		NCI	7526037
IRS1	3667	GLIMEPIRIDE	CHEMBL1481		NCI	15710354
IRS1	3667	PRASTERONE	CHEMBL90593		NCI	15501480

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
IRS1	rs7578326	G	Drugs Used In Diabetes	efficacy	no	Cases were patients requiring insulin therapy added either on or instead of maximal or near-maximal doses of oral antidiabetes drugs (OADs). Controls were patients who were in acceptable glycemic control (HbA1c<=8%) in the absence of insulin therapy. OADs were mostly sulfonylureas and metformin; 2-4% of patients were also on thiazolidinediones and/or gliptins.	Allele G is not associated with response to Drugs Used In Diabetes in people with Diabetes Mellitus, Type 2 as compared to allele A.	28696414	1449164659
IRS1	rs2943641	T	Drugs Used In Diabetes	efficacy	no	Cases were patients requiring insulin therapy added either on or instead of maximal or near-maximal doses of oral antidiabetes drugs (OADs). Controls were patients who were in acceptable glycemic control (HbA1c<=8%) in the absence of insulin therapy. OADs were mostly sulfonylureas and metformin; 2-4% of patients were also on thiazolidinediones and/or gliptins.	Allele T is not associated with response to Drugs Used In Diabetes in people with Diabetes Mellitus, Type 2 as compared to allele C.	28696414	1449164647
IRS1	rs1801278	CT + TT	Drugs Used In Diabetes	efficacy	yes	Cases were patients requiring insulin therapy added either on or instead of maximal or near-maximal doses of oral antidiabetes drugs (OADs). Controls were patients who were in acceptable glycemic control (HbA1c<=8%) in the absence of insulin therapy. OADs were mostly sulfonylureas and metformin; 2-4% of patients were also on thiazolidinediones and/or gliptins. Individuals carrying the minor T allele tended to be more frequent among cases as compared to controls. When this data was meta-analyzed with a previous independent study (Sesti et al. (2004) PMID: 15161794), significant results were also obtained. Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes CT + TT is associated with decreased response to Drugs Used In Diabetes in people with Diabetes Mellitus, Type 2 as compared to genotype CC.	28696414	1449164633