PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM2	3	IL2RB	1	affinity chromatography technology	Drissi R (2015)	1
STAT3	0	LCK	0	two hybrid	Grossmann A (2015)	1
RACK1	2	STAT1	1	affinity chromatography technology, pull down, affinity chromatography technology	Usacheva A (2003), Usacheva A (2001), Usacheva A (2001)	3
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
MCM2	3	RACK1	2	affinity chromatography technology	Drissi R (2015)	1
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
IL2RB	1	STAT1	1	pull down	Delespine-Carmagnat M (2000)	1
STAT5A	4	JAK2	1	affinity chromatography technology, two hybrid, pull down, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Fujitani Y (1997), Gouilleux F (1994)	4
RACK1	2	IL2RB	1	pull down	Usacheva A (2003)	1
JAK1	6	STAT3	0	pull down, affinity chromatography technology, affinity chromatography technology	Ueda T (2002), Spiekermann K (2001), Andl CD (2004)	3
IL2RB	1	STAT3	0	pull down	Delespine-Carmagnat M (2000)	1
RACK1	2	JAK1	6	affinity chromatography technology, pull down, affinity chromatography technology	Usacheva A (2003), Usacheva A (2003), Renga B (2012)	3
IL2RB	1	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Yamashita Y (2008), Yamashita Y (2008), Amano Y (2011), Amano Y (2011)	4
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
CISH	1	RACK1	2	affinity chromatography technology	Zhang W (2008)	1
IL2RB	1	SHC1	0	pull down, affinity chromatography technology	Delespine-Carmagnat M (2000), Ravichandran KS (1994)	2
STAT5B	3	JAK2	1	affinity chromatography technology, two hybrid, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Varghese LN (2014)	3
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
SHC1	0	STAT5B	3	affinity chromatography technology	Dinerstein-Cali H (2000)	1
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
LCK	0	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Venkitachalam S (2011), Venkitachalam S (2011)	2
STAT5B	3	STAT3	0	imaging technique	Chen TC (2014)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
IL2RB	1	ECM1	1	affinity chromatography technology	Li Z (2011)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
SHC1	0	JAK2	1	pull down, pull down	VanderKuur J (1995), Giordano V (1997)	2
SHB	4	JAK1	6	pull down	Lindholm CK (2002)	1
STAT5A	4	STAT5B	3	affinity chromatography technology	Huttlin EL (2017)	1
STAT1	1	STAT5A	4	imaging technique	Chen TC (2014)	1
JAK1	6	SOCS1	1	affinity chromatography technology	Park ES (2000)	1
JAK2	1	STAT3	0	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ram PA (1997), Manea A (2010), Andl CD (2004), Kamakura S (2004), He K (2013), Kucia-Tran JA (2016), M L (2016)	7
SHC1	0	STAT5A	4	affinity chromatography technology	Dinerstein-Cali H (2000)	1
NEDD4	2	IL2RB	1	affinity chromatography technology	Malarde V (2009)	1
IL2RB	1	STAT5B	3	pull down	Delespine-Carmagnat M (2000)	1
STAT3	0	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology	Gunaje JJ (2001), Spiekermann K (2001), Xia L (2002), Chen TC (2014), Li X (2015), Ghosh MK (2005), Huttlin EL (2017)	7
JAK1	6	IL2RB	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miyazaki T (1994), Russell SM (1994), Usacheva A (2002), Zhu MH (1998), Migone TS (1998), Tanaka N (1994)	6
JAK2	1	SOCS1	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yasukawa H (1999), Dif F (2001), Endo TA (1997), Endo TA (1997), Endo TA (1997), Yasukawa H (1999), Yasukawa H (1999), Pezet A (1999), Ungureanu D (2002), Masuhara M (1997), Ali S (2003), Monni R (2001), Monni R (2001), Piessevaux J (2008), Yu L (2009), Maruoka M (2017)	16
IL2RB	1	STAT5A	4	pull down	Delespine-Carmagnat M (2000)	1
SHB	4	IL2RB	1	pull down	Lindholm CK (2002)	1
JAK1	6	STAT5B	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	3
LCK	0	SOCS3	0	affinity chromatography technology	Venkitachalam S (2011)	1
JAK2	1	STAT1	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Cheng MB (2010), Cheng MB (2010), Manea A (2010), Andl CD (2004), Chang YJ (2004)	5
SHB	4	GRB2	2	affinity chromatography technology	Welsh M (1998)	1
IL2RB	1	JAK2	1	affinity chromatography technology	Zhu MH (1998)	1
IL2RB	1	GRB2	2	pull down	Delespine-Carmagnat M (2000)	1
IL2RB	1	SOCS1	1	affinity chromatography technology	Sporri B (2001)	1
JAK1	6	STAT5A	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	4
MCM2	3	GRB2	2	affinity chromatography technology	Drissi R (2015)	1
JAK1	6	STAT1	1	affinity chromatography technology, affinity chromatography technology	Andl CD (2004), Chang YJ (2004)	2
IL2RB	1	CISH	1	affinity chromatography technology, affinity chromatography technology	Aman MJ (1999), Aman MJ (1999)	2
GRB2	2	HGS	5	affinity chromatography technology	Bisson N (2011)	1
LCK	0	IL2RB	1	affinity chromatography technology	Reneer MC (2011)	1
LCK	0	CISH	1	affinity chromatography technology	Venkitachalam S (2011)	1
SOCS3	0	IL2RB	1	pull down	Cohney SJ (1999)	1