PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ID3	0	IKBKG	0	two hybrid	Ravasi T (2010)	1
ZNF626	0	ID3	0	two hybrid	Gao J (2008)	1
IKBKG	0	CDK2	0	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010)	3
CNOT3	11	ID3	0	two hybrid	Gao J (2008)	1
ZNF3	0	FHL2	0	two hybrid	Gao J (2008)	1
MYOD1	0	ID3	0	affinity chromatography technology	Langlands K (1997)	1
FHL2	0	ZNF626	0	two hybrid	Gao J (2008)	1
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
FHL2	0	CSK	3	two hybrid	Gao J (2008)	1
ATF3	0	FHL2	0	two hybrid, two hybrid, affinity chromatography technology	Gao J (2008), Gao J (2008), Gao J (2008)	3
ZNF3	0	ID3	0	two hybrid	Gao J (2008)	1
MYOD1	0	TCF3	7	pull down, two hybrid, pull down, two hybrid	Maleki SJ (1997), Langlands K (1997), Dear TN (1997), Dear TN (1997)	4
ID3	0	TCF4	26	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Chen B (1997), Chen B (1997), Langlands K (1997), Rolland T (2014), Li X (2015), Huttlin EL (2017)	6
TCF4	26	CBFA2T2	3	affinity chromatography technology	Li X (2015)	1
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
UNK	3	ID3	0	affinity chromatography technology	Murn J (2015)	1
VHL	0	ELOC	0	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Tsuchiya H (1996), Min JH (2002), Li Z (2002), Hacker KE (2008), Kim BY (2008), Baek JH (2007), Baek JH (2007), Kuznetsova AV (2003), Cockman ME (2000), Lisztwan J (1999), Stickle NH (2004), Lai Y (2011), Liu YV (2007), Norman JA (2006), Kinoshita K (2007), Cai Q (2010), Lai Y (2012), Miller F (2005), Mahrour N (2008), Mahrour N (2008), Russell RC (2011), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Stebbins CE (1999), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	48
GNB2	3	ID3	0	two hybrid	Gao J (2008)	1
FHL2	0	PUF60	16	two hybrid	Gao J (2008)	1
E2F4	0	FHL2	0	two hybrid	Schlisio S (2002)	1
PUF60	16	ID3	0	two hybrid	Gao J (2008)	1
TCF3	7	ID3	0	two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Deed RW (1998), Deed RW (1998), Langlands K (1997), Teachenor R (2012), Rolland T (2014), Langlands K (1997)	6
ATF3	0	ID3	0	two hybrid	Gao J (2008)	1
TCF4	26	MYOD1	0	two hybrid	Goldfarb AN (1996)	1
GATA4	4	NKX2-5	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Garg V (2003), Durocher D (1997), Durocher D (1997), Zhu W (2000), Zhu W (2000), Kim TG (2004), Kim TG (2004)	7
ID3	0	FAM74A1	0	two hybrid	Rolland T (2014)	1
ZNF408	0	ID3	0	two hybrid	Gao J (2008)	1
SREBF1	5	ID3	0	pull down	Moldes M (1999)	1
TCF12	14	TCF3	7	affinity chromatography technology	Yoon SJ (2011)	1
MLX	0	ID3	0	two hybrid	Gao J (2008)	1
ID3	0	TCF12	14	two hybrid, two hybrid	Langlands K (1997), Rolland T (2014)	2
ID3	0	GATA4	4	affinity chromatography technology, pull down, pull down	Ding B (2006), Ding B (2006), Ding B (2006)	3
VHL	0	CDK2	0	affinity chromatography technology	Ewing RM (2007)	1
CSK	3	ID3	0	two hybrid	Gao J (2008)	1
CDK2	0	ID3	0	enzymatic study	Deed RW (1997)	1
ID3	0	VHL	0	affinity chromatography technology	Lee SB (2016)	1
ID3	0	NKX2-5	0	affinity chromatography technology	Ding B (2006)	1
CBFA2T2	3	PRDM14	1	two hybrid, two hybrid, affinity chromatography technology	Ravasi T (2010), Rolland T (2014), Huttlin EL (2017)	3
ID3	0	CBFA2T2	3	two hybrid	Ravasi T (2010)	1
ID3	0	SAP30	1	two hybrid	Ravasi T (2010)	1
ID3	0	PRDM14	1	two hybrid	Ravasi T (2010)	1
E2F4	0	ID3	0	two hybrid	Ravasi T (2010)	1
RND1	0	ID3	0	two hybrid	Gao J (2008)	1
ID3	0	ID3	0	two hybrid	Gao J (2008)	1
ID3	0	ELOC	0	affinity chromatography technology	Lee SB (2016)	1
FHL2	0	ID3	0	two hybrid	Gao J (2008)	1
CDK2	0	PUF60	16	affinity chromatography technology	Neganova I (2011)	1
SMURF2	3	ID3	0	enzymatic study, affinity chromatography technology	Kong Y (2011), Kong Y (2011)	2
ID3	0	PAX5	7	affinity chromatography technology	Klenova E (2002)	1
FHL2	0	ZNF408	0	two hybrid, two hybrid, affinity chromatography technology	Gao J (2008), Gao J (2008), Gao J (2008)	3
CDK2	0	E2F4	0	affinity chromatography technology	So J (2015)	1
CDK2	0	GNB2	3	affinity chromatography technology	Neganova I (2011)	1