PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VCP	6	HSP90B1	3	biochemical	Wan C (2015)	1
SELENOS	0	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ye Y (2004), Wang Q (2008), Ballar P (2007), Ballar P (2007), Schulze A (2005), Zhong Y (2011), Zhong Y (2011), Christianson JC (2012), Liu Y (2014), Noda C (2014), Lee JH (2014), Mountassif D (2015)	13
APOB	8	LRP6	3	pull down	Liu W (2008)	1
P2RY12	0	YIPF3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANLN	2	MYH9	19	affinity chromatography technology	Hein MY (2015)	1
TMEM41B	0	APOB	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Yao Z (2017)	4
EGFR	5	CRKL	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
AUP1	0	APOB	8	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Zhang J (2017), Zhang J (2017)	4
EGFR	5	AKT2	1	affinity chromatography technology	Tong J (2014)	1
ZFYVE27	7	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
YIPF3	2	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
YIPF3	2	SYVN1	2	affinity chromatography technology	Huttlin EL (2017)	1
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
HSP90B1	3	DERL1	2	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	HSP90B1	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Yao Z (2017)	3
APOB	8	PRDX4	0	two hybrid	Wang J (2011)	1
SMAD3	1	UCHL5	1	pull down, affinity chromatography technology	Wicks SJ (2005), Nan L (2016)	2
SYVN1	2	DERL1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schulze A (2005), Schulze A (2005), Ye Y (2005), Bernardi KM (2010), Huang CH (2013), van de Weijer ML (2014), Hosokawa N (2016)	7
UCHL5	1	APOA1	0	affinity chromatography technology	Fang Y (2011)	1
TMEM128	0	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
APOB	8	PDIA4	3	affinity chromatography technology, biochemical, affinity chromatography technology	Zhang J (2003), Zhang J (2003), Linnik KM (1998)	3
CRKL	1	APOB	8	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	FAF2	4	affinity chromatography technology	Tong J (2014)	1
DERL1	2	EGFR	5	affinity chromatography technology, affinity chromatography technology	Dong QZ (2013), Dong QZ (2013)	2
SLC22A9	5	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
APOB	8	HSPA5	0	affinity chromatography technology	Rutledge AC (2009)	1
PAX6	3	APOB	8	affinity chromatography technology	Hein MY (2015)	1
MLF1	2	APOB	8	affinity chromatography technology	Huttlin EL (2015)	1
SELENOS	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Schulze A (2005)	2
APOB	8	HSP90B1	3	affinity chromatography technology, biochemical, affinity chromatography technology	Zhang J (2003), Zhang J (2003), Linnik KM (1998)	3
SEC61B	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, biochemical	Liao HJ (2009), Wang YN (2010), Wang YN (2010)	3
MYH9	19	APOB	8	affinity chromatography technology	Hein MY (2015)	1
TMPO	0	CANX	4	affinity chromatography technology	Brady GF (2018)	1
APOB	8	CALCR	0	affinity chromatography technology, biochemical	Zhang J (2003), Zhang J (2003)	2
SLC2A2	2	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
TMPO	0	MYH9	19	affinity chromatography technology	Brady GF (2018)	1
CALR	1	HSP90B1	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MZT1	1	APOB	8	affinity chromatography technology	Hein MY (2015)	1
APOB	8	LIPC	2	pull down	Choi SY (1998)	1
AUP1	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
FAF2	4	HSP90B1	3	affinity chromatography technology	Christianson JC (2012)	1
MFSD4A	2	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
LITAF	0	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
B3GALT2	1	APOB	8	affinity chromatography technology	Huttlin EL (2015)	1
AUP1	0	RPN2	0	affinity chromatography technology	Klemm EJ (2011)	1
DERL1	2	CANX	4	affinity chromatography technology	You H (2017)	1
VCP	6	CALR	1	biochemical	Wan C (2015)	1
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
SEC61A1	1	APOB	8	affinity chromatography technology	Chen Y (1998)	1
APOB	8	SELENOS	0	affinity chromatography technology	Rutledge AC (2009)	1
CALR	1	APOB	8	affinity chromatography technology, affinity chromatography technology	Tatu U (1999), Linnik KM (1998)	2
EGFR	5	SEC61A1	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Wang YN (2010)	2
HSP90B1	3	HSPA5	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
UCHL5	1	APOB	8	affinity chromatography technology	Fang Y (2011)	1
RPN2	0	VCP	6	biochemical	Wan C (2015)	1
APOB	8	PPIB	1	affinity chromatography technology, biochemical	Zhang J (2003), Zhang J (2003)	2
ANLN	2	APOB	8	affinity chromatography technology	Hein MY (2015)	1
SLC10A7	0	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
APOB	8	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fisher EA (2008), Rutledge AC (2009), Zhang J (2017)	3
P2RY12	0	APOB	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKT2	1	APOA1	0	two hybrid	Wang J (2011)	1
SELENOS	0	FAF2	4	affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012)	2
SMPD3	5	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
HSPA5	0	PPIB	1	biochemical	Havugimana PC (2012)	1
SMAD3	1	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
P2RY14	4	APOB	8	affinity chromatography technology	Huttlin EL (2015)	1
SYVN1	2	HSPA5	0	affinity chromatography technology	Wu ZZ (2011)	1
APOB	8	FAF2	4	affinity chromatography technology, affinity chromatography technology	Suzuki M (2012), Huttlin EL (2015)	2
ZDHHC11	2	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	MYH9	19	affinity chromatography technology	Chiu HC (2012)	1
EGFR	5	CANX	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong J (2014), Li J (2013), Yao Z (2017)	3
UCHL5	1	HSPA5	0	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Fang Y (2011), Fang Y (2011), Fang Y (2011), Fang Y (2011), Fang Y (2011)	5
EGFR	5	APOB	8	affinity chromatography technology, affinity chromatography technology	Li J (2013), Yao Z (2017)	2
YIPF2	1	APOB	8	affinity chromatography technology	Huttlin EL (2015)	1
APOB	8	MTTP	3	two hybrid, affinity chromatography technology	Bradbury P (1999), Walsh MT (2015)	2
AUP1	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011), Christianson JC (2012), Christianson JC (2012)	4
SLC18A1	2	APOB	8	affinity chromatography technology	Huttlin EL (2015)	1
VCP	6	CANX	4	affinity chromatography technology, biochemical	Yu CC (2013), Wan C (2015)	2
TMPO	0	PPIB	1	affinity chromatography technology	Brady GF (2018)	1
APOB	8	APOB	8	affinity chromatography technology	Rutledge AC (2009)	1
ARX	2	APOB	8	affinity chromatography technology	Hein MY (2015)	1
TMPO	0	HSPA5	0	affinity chromatography technology	Brady GF (2018)	1
SLC38A6	2	APOB	8	affinity chromatography technology	Huttlin EL (2015)	1
AKT2	1	APOB	8	two hybrid	Wang J (2011)	1
APOA1	0	VCP	6	affinity chromatography technology	Rutledge AC (2009)	1
TMPO	0	APOB	8	affinity chromatography technology	Brady GF (2018)	1
RAD21	3	APOB	8	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Hein MY (2015)	2
CANX	4	RPN2	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SYVN1	2	FAF2	4	affinity chromatography technology	Zhang T (2015)	1
APOB	8	SMAD3	1	two hybrid	Wang J (2011)	1
APOB	8	BGN	0	pull down	Flood C (2002)	1
TMPO	0	MTTP	3	affinity chromatography technology	Brady GF (2018)	1
DERL1	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Suzuki M (2012), Suzuki M (2012), Xu Y (2013), Christianson JC (2012), Christianson JC (2012)	6
HSPA5	0	MYH9	19	biochemical	Havugimana PC (2012)	1
PLIN2	0	APOB	8	affinity chromatography technology	Suzuki M (2012)	1
CANX	4	HSP90B1	3	biochemical	Wan C (2015)	1
VCP	6	HSPA5	0	affinity chromatography technology	Yu CC (2013)	1
CALR	1	CANX	4	affinity chromatography technology	Oliver JD (1999)	1
YIPF3	2	CANX	4	biochemical	Tanimoto K (2011)	1
UCHL5	1	PSMD14	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Wang X (2007), Jacobson AD (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
EGFR	5	PPIB	1	affinity chromatography technology	Yao Z (2017)	1
RPN2	0	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
TMPO	0	VCP	6	affinity chromatography technology	Brady GF (2018)	1
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
CANX	4	APOB	8	affinity chromatography technology, affinity chromatography technology	Vilas GL (2004), Liao W (1998)	2
SYVN1	2	MYH9	19	affinity chromatography technology	Christianson JC (2012)	1
HSPA5	0	FAF2	4	affinity chromatography technology	Hein MY (2015)	1
SEC61A1	1	SEC61B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang B (2008), Kalies KU (1998), Schorr S (2015)	3
SEC61B	0	CANX	4	biochemical	Wan C (2015)	1
APOB	8	PSMD14	3	biochemical	Wan C (2015)	1
APOB	8	SYVN1	2	affinity chromatography technology	Rutledge AC (2009)	1
APOB	8	ARFGAP1	3	two hybrid	Wang J (2011)	1
AUP1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011), Raman M (2015)	3
EGFR	5	CALR	1	affinity chromatography technology	Tong J (2014)	1
SELENOS	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ballar P (2007), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Zhong Y (2011), Christianson JC (2012)	7
RPN2	0	HSP90B1	3	biochemical	Wan C (2015)	1
SEC61B	0	APOB	8	affinity chromatography technology	Chen Y (1998)	1
SLC37A3	1	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
RAD21	3	TMPO	0	affinity chromatography technology	Panigrahi AK (2011)	1
CKLF	0	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
HSPA5	0	SEC61A1	1	unspecified method, affinity chromatography technology	Schaeuble N (2012), Schorr S (2015)	2
APOA1	0	APOB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rutledge AC (2009), Rutledge AC (2009), Zhang J (2017), Zhang J (2017)	4
APOB	8	DERL1	2	affinity chromatography technology, affinity chromatography technology	Rutledge AC (2009), Suzuki M (2012)	2
TMPO	0	FAF2	4	affinity chromatography technology	Brady GF (2018)	1