Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
APOB 338 EPIGALOCATECHIN GALLATE CHEMBL297453 NCI 11936850
APOB 338 TRIFLUOPERAZINE CHEMBL422 NCI 7595077
APOB 338 HEPARIN CHEMBL1909300 NCI 2457642, 9521691
APOB 338 MIPOMERSEN CHEMBL2219536 TdgClinicalTrial
APOB 338 HYDROCORTISONE CHEMBL389621 NCI 1597147
APOB 338 IRBESARTAN CHEMBL1513 PharmGKB
APOB 338 VITAMIN E CHEMBL47 NCI 7649489
APOB 338 ALCOHOL CHEMBL545 NCI 8576634
APOB 338 LOVASTATIN CHEMBL503 NCI 1588827, 2351867, 7662319
APOB 338 ATORVASTATIN CHEMBL1487 NCI 10357840, 10537160, 11882317, 12119202, 12145148, 12562847, 15353498, 15864114, 9598838
APOB 338 CHOLESTYRAMINE CHEMBL1201625 NCI 3906004
APOB 338 PRAVASTATIN CHEMBL1144 NCI 8312689
APOB 338 QUERCETIN CHEMBL50 NCI 16149735
APOB 338 NEVIRAPINE CHEMBL57 NCI 12869587
APOB 338 DEXAMETHASONE CHEMBL384467 NCI 7670964
APOB 338 FENOFIBRATE CHEMBL672 NCI 12606523
APOB 338 CHONDROITIN SULFATE CHEMBL2303614 NCI 9409221

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
APOB rs1367117 GG irbesartan efficacy yes reduction in systolic blood pressure. Treatment was with 150 mg/day for 12 weeks. The dose was doubled after six weeks if the diastolic blood pressure was >= 90 mmHg. Avg reduction in G carriers was 14 mm Hg. Genotype GG is associated with response to irbesartan in people with Hypertension. 15453913 655387074
APOB rs676210 AA fenofibrate efficacy yes AA genotype participants had greater lowering of triglycerides than did AG or GG individuals. Genotype AA is associated with increased response to fenofibrate in people with Hypertriglyceridemia as compared to genotypes AG + GG. 20724655 981500768
APOB rs1801701 CC irbesartan efficacy yes Patients with the CC genotype had a greater change in left ventricular mass between baseline and after 12 weeks of treatment, compared to other genotypes. Please note alleles have been complemented to the plus chromosomal strand. Genotype CC is associated with increased response to irbesartan in people with Hypertrophy, Left Ventricular as compared to genotypes CT + TT. 15614026 982036630
APOB rs1367117 AG irbesartan "efficacy","metabolism/PK" yes reduction in systolic blood pressure. Treatment was with 150 mg/day for 12 weeks. The dose was doubled after six weeks if the diastolic blood pressure was >= 90 mm Hg. Avg reduction in G carriers was 14 mm Hg. Genotype AG is associated with response to irbesartan in people with Hypertension. 15453913 655387073