Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HTR3A 3359 PALONOSETRON CHEMBL1189679 antagonist TdgClinicalTrial, TEND, DrugBank, TTD 14640928, 11752352, 15102873, 15378559, 15232725, 17026451, 14760130, 15139789, 14635083, 19852528, 16163194, 17106506, 14504060
HTR3A 3359 CISAPRIDE CHEMBL1729 agonist TdgClinicalTrial, DrugBank 8093733, 9697104, 10328995, 1600046
HTR3A 3359 TROPISETRON CHEMBL56564 antagonist DrugBank, TTD
HTR3A 3359 PRUCALOPRIDE CHEMBL117287 TdgClinicalTrial
HTR3A 3359 CHEMBL1188853 CHEMBL1188853 antagonist TdgClinicalTrial, TTD
HTR3A 3359 ALOSETRON HYDROCHLORIDE CHEMBL1200885 antagonist ChemblInteractions
HTR3A 3359 TUBOCURARINE CHEMBL339427 antagonist DrugBank 16723497, 12243766, 10066903, 1691468, 7684066
HTR3A 3359 TAPENTADOL CHEMBL1201776 DrugBank 10592235
HTR3A 3359 GRANISETRON CHEMBL289469 antagonist TdgClinicalTrial, ChemblInteractions, TEND, TTD
HTR3A 3359 GRANISETRON HYDROCHLORIDE CHEMBL1237080 antagonist ChemblInteractions
HTR3A 3359 PALONOSETRON HYDROCHLORIDE CHEMBL1720 antagonist ChemblInteractions
HTR3A 3359 METHADONE CHEMBL651 antagonist DrugBank 19131665
HTR3A 3359 OLANZAPINE CHEMBL715 antagonist TdgClinicalTrial, DrugBank 17848919
HTR3A 3359 CLOZAPINE CHEMBL42 antagonist PharmGKB, DrugBank 17848919
HTR3A 3359 MIRTAZAPINE CHEMBL654 antagonist TdgClinicalTrial, TEND, DrugBank 11752352, 8930006, 10446735, 10446734, 17587360, 11607047
HTR3A 3359 LOXAPINE CHEMBL831 binder DrugBank
HTR3A 3359 PROCAINE CHEMBL569 antagonist DrugBank, TTD 7539114, 11752352
HTR3A 3359 PUMOSETRAG CHEMBL1643880 TdgClinicalTrial, DrugBank
HTR3A 3359 VORTIOXETINE CHEMBL2104993 antagonist TdgClinicalTrial, DrugBank 21486038
HTR3A 3359 ROCURONIUM CHEMBL1201244 TdgClinicalTrial
HTR3A 3359 ONDANSETRON CHEMBL46 agonist, antagonist TdgClinicalTrial, ChemblInteractions, TEND, TTD
HTR3A 3359 TEDATIOXETINE CHEMBL2104986 antagonist TdgClinicalTrial, ChemblInteractions
HTR3A 3359 TEGASEROD CHEMBL76370 TdgClinicalTrial
HTR3A 3359 VELUSETRAG CHEMBL2087337 TdgClinicalTrial
HTR3A 3359 NARONAPRIDE CHEMBL2103858 TdgClinicalTrial
HTR3A 3359 LERISETRON CHEMBL56900 antagonist TTD
HTR3A 3359 VORTIOXETINE HYDROBROMIDE CHEMBL2107387 antagonist ChemblInteractions
HTR3A 3359 RG3487 CHEMBL3544952 antagonist ChemblInteractions
HTR3A 3359 Dolasetron Mesylate CHEMBL2368924 antagonist ChemblInteractions
HTR3A 3359 METOCLOPRAMIDE HYDROCHLORIDE HYDRATE CHEMBL1200940 antagonist ChemblInteractions
HTR3A 3359 ONDANSETRON HYDROCHLORIDE CHEMBL1201111 antagonist ChemblInteractions
HTR3A 3359 DOLASETRON CHEMBL2368925 antagonist TdgClinicalTrial, TEND, DrugBank, TTD 9257083, 9341357, 14586600, 15740177, 11752352, 9506240, 1397053, 14635083, 7493546, 8141114
HTR3A 3359 ARIPIPRAZOLE CHEMBL1112 antagonist DrugBank 17848919
HTR3A 3359 RENZAPRIDE CHEMBL159825 antagonist TdgClinicalTrial, DrugBank, TTD 16696817
HTR3A 3359 J-113,397 CHEMBL357076 antagonist TTD
HTR3A 3359 ALOSETRON CHEMBL1110 TdgClinicalTrial, TEND
HTR3A 3359 ESMIRTAZAPINE CHEMBL1366933 TdgClinicalTrial
HTR3A 3359 LEVETIRACETAM CHEMBL1286 antagonist TTD
HTR3A 3359 MOSAPRIDE CHEMBL60889 TdgClinicalTrial
HTR3A 3359 AMOXAPINE CHEMBL1113 antagonist DrugBank 1666997
HTR3A 3359 CILANSETRON CHEMBL2103778 antagonist TdgClinicalTrial, ChemblInteractions, DrugBank 16898618, 15757394

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HTR3A rs1062613 CC granisetron efficacy no Genotype CC is not associated with response to granisetron in healthy individuals as compared to genotypes CT + TT. 28002447 1448995554
HTR3A rs2276302 G clozapine efficacy yes Response was defined as a Brief Psychiatric Rating Scale (BPRS) total score of less than or equal to 35. Patients with the G allele had an increased likelihood of response to clozapine. Allele G is associated with increased response to clozapine in people with Schizophrenia as compared to allele A. 22700043 981954198
HTR3A rs1062613 T clozapine efficacy yes Response was defined as a Brief Psychiatric Rating Scale (BPRS) total score of less than or equal to 35. Patients with the T allele had an increased likelihood of response to clozapine. Allele T is associated with increased response to clozapine in people with Schizophrenia as compared to allele C. 22700043 981953971
HTR3A rs1150226 G clozapine efficacy yes As part of a haplotype: The A-C-C haplotype composed by rs2276302-rs1062613-rs1150226 was associated with better response (responder frequency 71.3%; non-responder frequency 57.9%, [chi]2=5.48; P=0.01; permutated P=0.04) whereas the G-T-T haplotype was nominally associated with worse response (responder frequency 5.9%; non-responder frequency 12.9%, [chi]2=3.98; P=0.04; permutated P=0.07). Allele G is associated with increased response to clozapine in people with Schizophrenia as compared to allele A. 20168265 827808147
HTR3A rs1062613 C clozapine efficacy yes As part of a haplotype: The A-C-C haplotype composed by rs2276302-rs1062613-rs1150226 was associated with better response (responder frequency 71.3%; non-responder frequency 57.9%, [chi]2=5.48; P=0.01; permutated P=0.04) whereas the G-T-T haplotype was nominally associated with worse response (responder frequency 5.9%; non-responder frequency 12.9%, [chi]2=3.98; P=0.04; permutated P=0.07) Allele C is associated with increased response to clozapine in people with Schizophrenia as compared to allele T. 20168265 827808121
HTR3A rs2276302 A clozapine efficacy yes As part of a haplotype: The A-C-C haplotype composed by rs2276302-rs1062613-rs1150226 was associated with better response (responder frequency 71.3%; non-responder frequency 57.9%, [chi]2=5.48; P=0.01; permutated P=0.04) whereas the G-T-T haplotype was nominally associated with worse response (responder frequency 5.9%; non-responder frequency 12.9%, [chi]2=3.98; P=0.04; permutated P=0.07). Allele A is associated with increased response to clozapine in people with Schizophrenia as compared to allele G. 20168265 827808138
HTR3A rs1176713 G risperidone efficacy no Please note that alleles have been complemented to the positive strand. Allele G is not associated with response to risperidone in people with Schizophrenia as compared to allele A. 28696411 1450928170
HTR3A rs1176713 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Please note that alleles have been complemented to the positive strand. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714932
HTR3A rs1062613 C opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele C is not associated with dose of opioids in people with Pain as compared to allele T. 21398039 1449714911
HTR3A rs2276302 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714918
HTR3A rs1176719 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714925