PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANKMY2	3	GUCY1A3	0	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
LIN7A	1	GUCY1A2	2	affinity chromatography technology	Hauri S (2013)	1
NOS3	7	APP	1	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
GUCY1B3	0	NOS3	7	pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Venema RC (2003)	3
GUCY1B3	0	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
LIN7A	1	GUCY1B3	0	affinity chromatography technology	Hauri S (2013)	1
GUCY1B3	0	BBS2	1	affinity chromatography technology	Huttlin EL (2017)	1
STUB1	4	GUCY1A3	0	affinity chromatography technology	Meurer S (2009)	1
GUCY1A2	2	GUCY1B3	0	affinity chromatography technology, affinity chromatography technology	Russwurm M (2001), Huttlin EL (2017)	2
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
NOX5	2	HSP90AA1	7	affinity chromatography technology	Chen F (2012)	1
GUCY1A2	2	STUB1	4	affinity chromatography technology, enzymatic study	Xia T (2007), Xia T (2007)	2
GUCY1A2	2	HSP90AA1	7	affinity chromatography technology	Xia T (2007)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
LIN7A	1	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	NOS3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Harris MB (2000), Harris MB (2000), Stepp DW (2002), Fontana J (2002), Fontana J (2002), Brouet A (2001), Brouet A (2001)	9
GUCY1B3	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Venema RC (2003)	3
GUCY1B3	0	UACA	8	affinity chromatography technology	Huttlin EL (2017)	1
STUB1	4	GUCY1B3	0	affinity chromatography technology	Meurer S (2009)	1
GUCY1B3	0	MYCBP2	11	affinity chromatography technology	Huttlin EL (2017)	1
GUCY1B3	0	MXRA7	0	affinity chromatography technology	Huttlin EL (2017)	1
NOX5	2	STUB1	4	affinity chromatography technology	Chen F (2012)	1
GUCY1B3	0	APP	1	pull down	Olah J (2011)	1
GUCY1B3	0	GUCY1A3	0	affinity chromatography technology	Huttlin EL (2017)	1
ANKMY2	3	HSP90AA1	7	affinity chromatography technology	Huttlin EL (2017)	1
ANKMY2	3	GUCY1B3	0	affinity chromatography technology	Huttlin EL (2017)	1
GUCY1B3	0	MTFR2	2	affinity chromatography technology	Huttlin EL (2017)	1
NOX5	2	GUCY1B3	0	affinity chromatography technology	Huttlin EL (2017)	1