PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BMPR1A	5	BMP2	2	x-ray crystallography, pull down, pull down, pull down	Nickel J (2001), Kirsch T (2000), Kirsch T (2000), Gilboa L (2000)	4
RGMB	1	BMP4	0	pull down	Samad TA (2005)	1
RGMB	1	BMP2	2	pull down	Samad TA (2005)	1
RGMB	1	ACVR2B	0	affinity chromatography technology	Samad TA (2005)	1
RGMB	1	ACVR2A	0	affinity chromatography technology	Samad TA (2005)	1
BMPR1A	5	BMPR1B	3	affinity chromatography technology, imaging technique	Gilboa L (2000), Gilboa L (2000)	2
ACVR1	4	BMPR1A	5	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Lavery K (2008), Lavery K (2008), Huttlin EL (2015), Huttlin EL (2017)	4
BMP4	0	BMPR1B	3	pull down	ten Dijke P (1994)	1
ACVR1	4	ACVR2A	0	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
RGMB	1	ACVR1	4	affinity chromatography technology	Samad TA (2005)	1
RGMB	1	BMPR1B	3	affinity chromatography technology	Samad TA (2005)	1
RGMB	1	BMPR1A	5	affinity chromatography technology	Samad TA (2005)	1
BMP4	0	BMPR1A	5	pull down	ten Dijke P (1994)	1
BMP2	2	BMPR1B	3	pull down	Gilboa L (2000)	1