PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
FBXO4	0	AMD1	2	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	TERF1	1	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	AMD1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
NEDD8	0	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
MCL1	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Hollville E (2014), Hollville E (2014)	2
FXR1	0	FMR1	1	two hybrid, biochemical, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1995), Siomi MC (1996), Zhang Y (1995), Zhang Y (1995), Li S (2014), Li S (2014), Huttlin EL (2015)	7
HSP90AA1	7	MCL1	1	genetic interference	Srivas R (2016)	1
PRKN	1	CUL1	7	affinity chromatography technology, pull down, affinity chromatography technology	Staropoli JF (2003), Staropoli JF (2003), Gong Y (2014)	3
CCND1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006), Wei S (2008), Yu ZK (1998)	4
UBE2D2	0	FBXO4	0	enzymatic study	Cenciarelli C (1999)	1
FBXO4	0	FBXO4	0	x-ray crystallography, affinity chromatography technology	Li Y (2010), Barbash O (2011)	2
AP1B1	6	AP1M1	3	two hybrid, biochemical, biochemical	Page LJ (1995), Havugimana PC (2012), Wan C (2015)	3
FBXO4	0	DEFA1B	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	UBE2D2	0	x-ray crystallography	Sakata E (2007)	1
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
FBXW8	2	FBXO4	0	affinity chromatography technology	Ponyeam W (2012)	1
NEDD8	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
MCL1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Ye M (2017), Feng C (2017)	2
FXR1	0	CUL1	7	affinity chromatography technology	Qie S (2017)	1
TERF1	1	FBXO4	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, two hybrid, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee TH (2006), Lee TH (2006), Lee TH (2006), Lee TH (2006), Zeng Z (2010), Zeng Z (2010), Zeng Z (2010), Li Y (2010), Li Y (2010), Zhu Q (2009), Lee EK (2013), Kim J (2014), Tan R (2017), Tan R (2017)	14
TP53	0	CCND1	1	affinity chromatography technology	Yang P (2016)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
CCND1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006)	2
FBXW8	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Litterman N (2011), Busino L (2012), Watanabe N (2004), Ponyeam W (2012), Tian X (2015), Xu X (2008), Hauri S (2016)	9
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
CUL1	7	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC34	3	FBXO4	0	enzymatic study	Cenciarelli C (1999)	1
TP53	0	SKP1	0	affinity chromatography technology	Fogeron ML (2013)	1
PRKN	1	CDC34	3	pull down	Kazlauskaite A (2014)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
FBXO4	0	ESPL1	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
MCL1	1	TP53	0	unspecified method, affinity chromatography technology	Lee MS (2014), Zhang X (2016)	2
MCL1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Ye M (2017), Feng C (2017)	2
FBXO4	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Li Y (2010), Li Y (2010), Hagens O (2006), Lee EK (2013), Tian X (2015), Huttlin EL (2017), Qie S (2017), Hauri S (2016)	12
YWHAE	0	FBXO4	0	affinity chromatography technology, pull down, affinity chromatography technology	Barbash O (2011), Barbash O (2011), Barbash O (2011)	3
FBXW8	2	CCND1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Okabe H (2007), Wei S (2008)	3
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
TP53	0	FBXW8	2	affinity chromatography technology	Li X (2015)	1
FBXO4	0	FXR1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Qie S (2017), Qie S (2017), Qie S (2017)	3
PRKN	1	FBXO4	0	affinity chromatography technology	Gong Y (2014)	1
FBXO4	0	AP1B1	6	affinity chromatography technology	Huttlin EL (2017)	1
FBXO4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Cenciarelli C (1999), Hagens O (2006), Choo YY (2011), Liu B (2012), Jeong YT (2013), Huttlin EL (2017), Reitsma JM (2017)	8
ELAVL1	0	FBXO4	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXO4	0	FMR1	1	affinity chromatography technology	Qie S (2017)	1
ELAVL1	0	CCND1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	FBXO4	0	affinity chromatography technology	Jin X (2009)	1
PRKN	1	YWHAE	0	affinity chromatography technology	Zanon A (2013)	1
FBXW8	2	HSP90AA1	7	affinity chromatography technology	Ponyeam W (2012)	1
NEDD8	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Hauri S (2016)	3
ELAVL1	0	FXR1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AA1	7	FBXO4	0	affinity chromatography technology	Taipale M (2012)	1
MCL1	1	FBXO4	0	affinity chromatography technology	Feng C (2017)	1
TP53	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
FBXW8	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Bennett EJ (2010), Liu B (2012), Low TY (2014), Reitsma JM (2017)	7
PRKN	1	CCND1	1	affinity chromatography technology, enzymatic study	Gong Y (2014), Gong Y (2014)	2
FXR1	0	SKP1	0	affinity chromatography technology	Qie S (2017)	1
FBXO4	0	AP1M1	3	affinity chromatography technology	Huttlin EL (2017)	1
CCND1	1	FBXO4	0	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Lin DI (2006), Lin DI (2006), Barbash O (2011), Lin DI (2006), Lin DI (2006), Lee EK (2013), Barbash O (2009), Qie S (2017), Qie S (2017), Gong Y (2014)	10
TERF1	1	SKP1	0	pull down	Li Y (2010)	1
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
FBXO4	0	NEDD8	0	affinity chromatography technology	Ewing RM (2007)	1
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1