PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DDOST	0	RPN1	2	biochemical	Wan C (2015)	1
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
FBXO6	0	RPN1	2	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Liu B (2012)	2
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
ASGR2	1	JMJD8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CLN5	1	RPN1	2	affinity chromatography technology	Scifo E (2013)	1
CLN5	1	FBXO6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scifo E (2013), Huttlin EL (2015), Huttlin EL (2017)	3
RPN2	0	DDOST	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
FBXO6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017), Reitsma JM (2017)	10
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
FBXO6	0	AGA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	H6PD	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	NAGLU	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	TFRC	1	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Liu B (2012)	2
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
FBXO6	0	FAM168A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	FBXO6	0	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Liu B (2012)	2
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
RPN1	2	RPN2	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
FBXO6	0	JMJD8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	DDOST	0	biochemical	Wan C (2015)	1
FBXO6	0	COPS6	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
FBXO6	0	ERO1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	HSPA13	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	RPN1	2	affinity chromatography technology	Yu CC (2013)	1
COPS6	0	SMC3	16	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXO6	0	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Liu B (2012)	2
FBXO6	0	PTGFRN	10	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
FBXO6	0	DDOST	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Liu B (2012)	2
FBXO6	0	PPT2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
FBXO6	0	NUDT9	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO6	0	EMC7	1	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
FBXO6	0	MAN2B1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	POFUT1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	ERO1A	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Liu B (2012)	2
EGFR	5	TFRC	1	affinity chromatography technology	Tong J (2014)	1
RPN2	0	VCP	6	biochemical	Wan C (2015)	1
FBXO6	0	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO6	0	GRN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
FBXO6	0	TOR1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	MAN2B2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
CUL1	7	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Min KW (2005), Min KW (2005), Yang X (2002), Yang X (2002), Huang X (2005), Bennett EJ (2010), Scherer PC (2016), Scherer PC (2016), Reitsma JM (2017)	9
FBXO6	0	ENTPD5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO6	0	RPN2	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Liu B (2012)	2
ASGR2	1	FBXO6	0	affinity chromatography technology, imaging technique	Groisman B (2011), Groisman B (2011)	2
FBXO6	0	SGSH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	POGLUT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	SMC3	16	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Liu B (2012)	2
ERO1B	1	ERO1A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Taipale M (2012)	2
EGFR	5	RPN1	2	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
VCP	6	UBB	4	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
EGFR	5	GRN	2	affinity chromatography technology	Tong J (2014)	1
FBXO6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Tian X (2015), Hauri S (2016)	9
COPS6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
FBXO6	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
EGFR	5	SMC3	16	affinity chromatography technology	Tong J (2014)	1
FBXO6	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
FBXO6	0	PRCP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015), Huttlin EL (2017)	3
FBXO6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
FBXO6	0	KDELC2	2	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2