PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	MDC1	8	affinity chromatography technology	Jung SY (2005)	1
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
JARID2	7	NKX2-5	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kim TG (2004), Kim TG (2004), Kim TG (2004), Kim TG (2004)	4
GATA4	4	SUZ12	0	affinity chromatography technology	He A (2012)	1
GATA4	4	EZH2	4	affinity chromatography technology, affinity chromatography technology	He A (2012), He A (2012)	2
SP1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won J (2002), Zhang Y (2002), Sun JM (2002), Glasspool RM (2005), Duan H (2005), Sekhavat A (2007), Itoh Y (2007), Marshall GM (2010), Tsai PF (2011), Schnur N (2007)	10
GATA4	4	SRF	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Belaguli NS (2000), Belaguli NS (2000), Morin S (2001), Morin S (2001)	4
MAPK1	1	GATA4	4	enzymatic study	Liang Q (2001)	1
TBX5	1	GATA4	4	affinity chromatography technology, affinity chromatography technology	Garg V (2003), Garg V (2003)	2
JARID2	7	EZH1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Pasini D (2010), Hauri S (2016), Hauri S (2016)	4
MAPK1	1	ID2	0	two hybrid	Wang J (2008)	1
FOXE1	2	GATA4	4	affinity chromatography technology	Li X (2015)	1
ID1	0	GATA4	4	affinity chromatography technology, pull down	Ding B (2006), Ding B (2006)	2
FOXE1	2	ALX4	1	affinity chromatography technology	Li X (2015)	1
EP300	36	GATA4	4	affinity chromatography technology	Takaya T (2008)	1
ID2	0	NKX2-5	0	affinity chromatography technology	Ding B (2006)	1
NKX2-5	0	TBX5	1	affinity chromatography technology, affinity chromatography technology, pull down	Garg V (2003), Hiroi Y (2001), Hiroi Y (2001)	3
EZH2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	van der Vlag J (1999), van der Vlag J (1999), Tong ZT (2012), Tong ZT (2012), Wan C (2015)	5
ZFPM2	4	HDAC2	1	affinity chromatography technology	Roche AE (2008)	1
EZH2	4	JARID2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Li G (2010), Li G (2010), Li G (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	11
ID1	0	NKX2-5	0	affinity chromatography technology	Ding B (2006)	1
SP1	0	NR5A1	1	pull down, two hybrid	Sugawara T (2000), Sugawara T (2000)	2
SP1	0	SRF	1	pull down	Biesiada E (1999)	1
GATA4	4	ZBTB3	3	two hybrid	Ravasi T (2010)	1
MAPK1	1	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
MDC1	8	GATA4	4	unspecified method	Rodriguez M (2003)	1
JARID2	7	HDAC2	1	affinity chromatography technology	Pasini D (2010)	1
FOXE1	2	NKX2-5	0	affinity chromatography technology	Li X (2015)	1
GATA4	4	NKX2-5	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Garg V (2003), Durocher D (1997), Durocher D (1997), Zhu W (2000), Zhu W (2000), Kim TG (2004), Kim TG (2004)	7
HDAC2	1	SUZ12	0	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Pasini D (2010), Wan C (2015)	3
GATA4	4	ZFPM2	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Svensson EC (1999), Svensson EC (1999), Svensson EC (1999), Takaya T (2008), Svensson EC (2000)	5
GATA4	4	HDAC2	1	affinity chromatography technology	Trivedi CM (2010)	1
KDM6A	8	HDAC2	1	genetic interference	Wong AS (2016)	1
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
EZH1	1	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008)	3
ID3	0	GATA4	4	affinity chromatography technology, pull down, pull down	Ding B (2006), Ding B (2006), Ding B (2006)	3
GATA4	4	SP1	0	affinity chromatography technology, pull down, pull down	Flueck CE (2004), Flueck CE (2004), Ito H (2011)	3
KDM6A	8	GATA4	4	affinity chromatography technology, affinity chromatography technology	Lee S (2012), Lee S (2012)	2
ID2	0	GATA4	4	affinity chromatography technology, pull down, pull down	Ding B (2006), Ding B (2006), Ding B (2006)	3
NR5A1	1	GATA4	4	pull down	Tremblay JJ (1999)	1
JARID2	7	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
KDM6A	8	NKX2-5	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Lee S (2012), Lee S (2012), Lee S (2012)	3
SRF	1	KDM6A	8	affinity chromatography technology, two hybrid	Lee S (2012), Lee S (2012)	2
ID3	0	NKX2-5	0	affinity chromatography technology	Ding B (2006)	1
TBX5	1	KDM6A	8	affinity chromatography technology, two hybrid	Lee S (2012), Lee S (2012)	2
GATA4	4	HAND2	1	pull down, affinity chromatography technology	Dai YS (2002), Dai YS (2002)	2
GATA4	4	JARID2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	He A (2012), Kim TG (2004), Kim TG (2004), Kim TG (2004), Kim TG (2004)	5
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
GATA4	4	EZH1	1	affinity chromatography technology	He A (2012)	1
HAND2	1	EP300	36	pull down	Dai YS (2002)	1
GATA4	4	ALX4	1	two hybrid	Ravasi T (2010)	1
EZH1	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8