Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
GATA4	rs4841588	TT	warfarin	dosage	yes	in Korean patients with prosthetic cardiac valves carrying CYP2C9*1/*1 (p=0.036), but not in the CYP2C9 variant group (p=0.114).	Genotype TT is associated with increased dose of warfarin as compared to genotypes GG + GT.	25026456	1184511628
GATA4	rs3735814	AG + GG	phenprocoumon	dosage	no		Genotypes AG + GG are not associated with decreased dose of phenprocoumon as compared to genotype AA.	23215884	1444706524
GATA4	rs2645400	TT	warfarin	dosage	yes	in Korean patients with prosthetic cardiac valves carrying CYP2C9*1/*1 (p=0.026), but not in the CYP2C9 variant group (p=0.122).	Genotype TT is associated with increased dose of warfarin as compared to genotypes GG + GT.	25026456	1184511624
GATA4	rs2645400	G	warfarin	dosage	no	Warfarin dose requirement was defined as the reported daily dose at 3 months following treatment initiation.	Allele G is not associated with dose of warfarin as compared to allele T.	29298995	1449164090
GATA4	rs3735814	AG + GG	acenocoumarol	dosage	yes	in the CYP2C9*1/*1 group, but not in the CYP2C9 variant allele group. The mean dosages decreased from 2.92 mg/day for the patients with the GATA-4 common alleles to 2.65 mg/day for the patients with one GATA-4 variant allele and to 2.37 mg/day for patients carrying two GATA-4 variant alleles. However, the authors could not replicate these findings in the Rotterdam Study and they did not see any association in the phenprocoumon users, suggesting the clinical implications of GATA4 SNPs are of minor relevance to acenocoumarol dose.	Genotypes AG + GG are associated with decreased dose of acenocoumarol as compared to genotype AA.	23215884	1444706513
GATA4	rs10090884	AA	warfarin	dosage	no	Average mean stable warfarin dose was 5.48+/-1.90 mg/day. Current age, age at operation, atrial fibrillation were all significantly associated with warfarin dose. Please note, alleles have been complimented to the + strand.	Genotype AA is not associated with dose of warfarin as compared to genotypes AC + CC.	26257249	1446765966
GATA4	rs4841588	G	warfarin	dosage	no	Warfarin dose requirement was defined as the reported daily dose at 3 months following treatment initiation.	Allele G is not associated with dose of warfarin as compared to allele T.	29298995	1449164097