PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GABPB1	0	TDRD7	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
PIMREG	0	TDRD7	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TDRD7	2	TDRD7	2	two hybrid	Rolland T (2014)	1
TDRD7	2	CDK17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Conte N (2003), Huttlin EL (2015), Huttlin EL (2017)	3
FRAT1	0	TDRD7	2	two hybrid	Wang J (2011)	1
ATXN2	3	TDRD7	2	two hybrid	Lim J (2006)	1
TDRD7	2	MAGEA8	1	two hybrid	Yu H (2011)	1
TACC1	2	TDRD7	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Conte N (2003), Conte N (2003), Conte N (2003), Conte N (2003)	4
CDKN2A	1	TDRD7	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2