PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HTT	14	IFT20	0	two hybrid	Suter B (2013)	1
ZDHHC17	1	GSK3A	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	GOLPH3L	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	PDPK1	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
SNW1	0	EEF1A1	0	affinity chromatography technology	Zhang C (2003)	1
ZDHHC17	1	WASF2	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	CAPN2	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	OPTN	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	TRIP10	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
GOLGA2	2	SNW1	0	two hybrid	Rolland T (2014)	1
ZDHHC17	1	FEZ2	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	IFT20	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	GPM6A	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Butland SL (2014), Butland SL (2014), Butland SL (2014)	3
ZDHHC17	1	DAXX	5	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	WAC	18	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	ARFGAP3	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
DAXX	5	GOLGA2	2	two hybrid	Rolland T (2014)	1
ZDHHC17	1	TAF8	2	two hybrid, affinity chromatography technology	Butland SL (2014), Huttlin EL (2015)	2
ZDHHC17	1	STX16	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	SETDB1	3	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
KLK8	2	RAB39B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HTT	14	EVL	4	two hybrid	Suter B (2013)	1
LASP1	1	SPRY2	4	two hybrid	Rolland T (2014)	1
SPRY2	4	ZDHHC17	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Butland SL (2014), Butland SL (2014), Huttlin EL (2015), Huttlin EL (2017)	5
ZDHHC17	1	FKBP6	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	SPRED2	12	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	PPP2R5E	4	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
LPAR1	1	ZDHHC17	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IFT57	1	IFT20	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
ZDHHC17	1	USP32	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	EVL	4	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	BAIAP2	6	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
BSCL2	2	ZDHHC17	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNW1	0	DAXX	5	affinity chromatography technology, affinity chromatography technology	Tang J (2005), Tang J (2005)	2
ZDHHC17	1	DNAH11	16	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
SNW1	0	APBB1IP	1	affinity chromatography technology	Lleres D (2010)	1
ZDHHC17	1	SNAP23	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	EEF1A1	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
GOLGA2	2	RAB39B	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZDHHC17	1	RAB39B	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
SPRY2	4	SPRY4	0	affinity chromatography technology	Mason JM (2004)	1
ZDHHC17	1	CNP	2	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
NRSN2	0	ZDHHC17	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GOLGA2	2	LASP1	1	two hybrid	Rolland T (2014)	1
HTT	14	ZDHHC17	1	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid	Faber PW (1998), Singaraja RR (2002), Singaraja RR (2002), Singaraja RR (2002), Suter B (2013), Butland SL (2014)	6
ZDHHC17	1	SPRY4	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	EIF3E	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	APBB1IP	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	LASP1	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
WASF2	0	BAIAP2	6	far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miki H (2000), Miki H (2000), Miki H (2000), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
ZDHHC17	1	ATF2	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
HTT	14	OPTN	1	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid	Faber PW (1998), Hattula K (2001), Hattula K (2001), Hattula K (2001), Suter B (2013)	5
EVL	4	WASF2	0	affinity chromatography technology	Huttlin EL (2017)	1
ZDHHC17	1	IFT57	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	PLEKHB1	2	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
HTT	14	PIK3R1	6	two hybrid	Suter B (2013)	1
PIK3R1	6	PDE4D	4	far western blotting	Beard MB (1999)	1
GOLGA2	2	IFT20	0	two hybrid	Rolland T (2014)	1
ZDHHC17	1	SNW1	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	SPRED1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Butland SL (2014), Butland SL (2014), Butland SL (2014)	3
ZDHHC17	1	FAM135B	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Butland SL (2014), Huttlin EL (2015), Huttlin EL (2017)	3
TRIP10	1	HTT	14	two hybrid, pull down	Holbert S (2003), Holbert S (2003)	2
ZDHHC17	1	CSNK1D	3	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	PDE4D	4	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	PIK3R1	6	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
PLSCR4	0	ZDHHC17	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NRG1	1	ZDHHC17	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZDHHC17	1	GOLGA2	2	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	SLC9A9	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	SLC25A31	0	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
ZDHHC17	1	KLK8	2	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
HTT	14	GOLPH3L	0	two hybrid	Suter B (2013)	1