PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CTBP1	2	IKZF2	3	two hybrid	Corominas R (2014)	1
IKZF1	2	HDAC5	4	affinity chromatography technology, affinity chromatography technology	Koipally J (2002), Koipally J (2002)	2
SIN3B	5	SIN3A	13	affinity chromatography technology	Hein MY (2015)	1
HDAC5	4	CTBP1	2	pull down	Zhang CL (2001)	1
NFATC1	12	IKZF1	2	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
HDAC1	4	SIN3B	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1999), Koipally J (1999), Romm E (2005), Humphrey GW (2001), Terhune SS (2010), Joshi P (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
IKZF2	3	IKZF2	3	affinity chromatography technology	Kelley CM (1998)	1
NFATC1	12	IKZF2	3	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
IKZF2	3	IKZF3	1	affinity chromatography technology	Kelley CM (1998)	1
NOTCH1	25	IKZF1	2	affinity chromatography technology	Yatim A (2012)	1
HDAC1	4	NFATC1	12	affinity chromatography technology	Nayak A (2009)	1
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
NOTCH1	25	IKZF2	3	affinity chromatography technology	Yatim A (2012)	1
IKZF3	1	CHD4	22	affinity chromatography technology	Koipally J (2002)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
CTBP1	2	CHD4	22	affinity chromatography technology	Huttlin EL (2017)	1
SIN3A	13	HDAC4	10	affinity chromatography technology, affinity chromatography technology	Farhana L (2007), Nakagawa Y (2006)	2
HDAC4	10	NFATC1	12	affinity chromatography technology	Nayak A (2009)	1
SIN3A	13	IKZF1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koipally J (2002), Koipally J (1999), Koipally J (2002), Koipally J (2002)	4
CTBP1	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Koipally J (2000), Glasspool RM (2005), Kuppuswamy M (2008), Kuppuswamy M (2008), Mendez LM (2008)	5
CTBP2	7	IKZF1	2	two hybrid, two hybrid, affinity chromatography technology	Rolland T (2014), Yu H (2011), Huttlin EL (2017)	3
CTBP2	7	IKZF2	3	two hybrid	Rolland T (2014)	1
IKZF1	2	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koipally J (2002), ONeill DW (2000), ONeill DW (2000), Huttlin EL (2017)	4
CHD4	22	SIN3A	13	affinity chromatography technology	Zhang Y (1998)	1
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
AQP1	1	IKZF2	3	two hybrid	Rolland T (2014)	1
NFATC1	12	NFATC2	1	affinity chromatography technology	Gabriel CH (2016)	1
IKZF2	3	LONRF1	4	two hybrid	Rolland T (2014)	1
IKZF1	2	HDAC4	10	affinity chromatography technology	Koipally J (2002)	1
IKZF2	3	HDAC4	10	pull down	Franco PJ (2003)	1
NOTCH1	25	CHD4	22	affinity chromatography technology	Yatim A (2012)	1
CTBP1	2	IKZF1	2	pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Koipally J (2000), Koipally J (2000), Vinayagam A (2011), Corominas R (2014), Rolland T (2014)	5
NFATC1	12	CHD4	22	affinity chromatography technology	Li X (2015)	1
NOTCH1	25	IKZF3	1	affinity chromatography technology	Yatim A (2012)	1
IKZF2	3	CHD4	22	affinity chromatography technology	Koipally J (2002)	1
IKZF1	2	IKZF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim J (1999), Hung KH (2016), Hung KH (2016), Huttlin EL (2017)	4
IKZF2	3	SIN3A	13	affinity chromatography technology	Koipally J (2002)	1
SIN3B	5	IKZF1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koipally J (1999), Koipally J (2002), Koipally J (2002)	3
IKZF5	0	IKZF2	3	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	IKZF2	3	affinity chromatography technology	Joshi P (2013)	1
IKZF3	1	SIN3B	5	affinity chromatography technology	Koipally J (2002)	1
IKZF3	1	HDAC2	1	affinity chromatography technology	Koipally J (2002)	1
IKZF2	3	SIN3B	5	affinity chromatography technology	Koipally J (2002)	1
HDAC5	4	NFATC1	12	enzymatic study, affinity chromatography technology	Kim JH (2011), Kim JH (2011)	2
NFATC2	1	CTBP1	2	affinity chromatography technology	Gabriel CH (2016)	1
IKZF1	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koipally J (2002), Kim J (1999), Kim J (1999)	3
HDAC4	10	CTBP1	2	pull down	Zhang CL (2001)	1
HDAC2	1	NFATC1	12	affinity chromatography technology, affinity chromatography technology	Nayak A (2009), Li X (2015)	2
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
NFATC1	12	CTBP1	2	affinity chromatography technology	Gabriel CH (2016)	1
NFATC2	1	HDAC1	4	affinity chromatography technology	Gabriel CH (2016)	1
IKZF3	1	IKZF5	0	pull down, two hybrid, affinity chromatography technology	Perdomo J (2000), Perdomo J (2000), Huttlin EL (2017)	3
HDAC1	4	CTBP1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang CL (2001), Melhuish TA (2000), Sundqvist A (1998), Jin W (2008), Joshi P (2013)	5
IKZF2	3	IKZF1	2	affinity chromatography technology, affinity chromatography technology	Kelley CM (1998), Huttlin EL (2017)	2
CTBP2	7	HDAC2	1	affinity chromatography technology	Zhao LJ (2009)	1
NFATC2	1	IKZF2	3	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
IKZF3	1	HDAC5	4	affinity chromatography technology	Koipally J (2002)	1
HDAC1	4	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), Grozinger CM (1999), Tong JK (1998), Tong JK (1998), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Terhune SS (2010), Polo SE (2010), Xue Y (1998), Xue Y (1998), Xue Y (1998), Kwintkiewicz J (2011), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Quan J (2014), Wan C (2015), Hein MY (2015), Weiss K (2016), Huttlin EL (2017)	28
IKZF3	1	HDAC4	10	affinity chromatography technology	Koipally J (2002)	1
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
HDAC5	4	SIN3A	13	affinity chromatography technology	Nakagawa Y (2006)	1
SIN3B	5	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Romm E (2005), Bantscheff M (2011)	2
AQP1	1	IKZF3	1	two hybrid	Rolland T (2014)	1
IKZF3	1	SIN3A	13	affinity chromatography technology	Koipally J (2002)	1
IKZF2	3	HDAC2	1	affinity chromatography technology	Koipally J (2002)	1
HDAC2	1	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hakimi MA (2003), Schmidt DR (1999), Schmidt DR (1999), Tong JK (1998), Tong JK (1998), Tong JK (1998), ONeill DW (2000), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Xue Y (1998), Xue Y (1998), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	17
IKZF2	3	HDAC5	4	affinity chromatography technology	Koipally J (2002)	1
HDAC1	4	IKZF1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koipally J (1999), Koipally J (2002), Kim J (1999), Kim J (1999), Joshi P (2013)	5
NOTCH1	25	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012)	2
NFATC2	1	CHD4	22	affinity chromatography technology	Gabriel CH (2016)	1
NFATC2	1	IKZF1	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016), Gabriel CH (2016)	3
IKZF1	2	IKZF5	0	pull down, two hybrid, affinity chromatography technology	Perdomo J (2000), Perdomo J (2000), Huttlin EL (2017)	3
HDAC2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Fleischer TC (2003), Fleischer TC (2003), Hakimi MA (2003), Yang L (2003), Laherty CD (1997), Zhang Y (2002), Tong JK (1998), Zhang Y (2005), Nakamura T (2002), Sekhavat A (2007), Zou J (2004), Sun JM (2007), Xue Y (1998), Tsai SC (2002), Brandl A (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hsu DS (2014)	20