PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CTTN	1	DNM2	2	affinity chromatography technology	Hashimoto S (2006)	1
FER	1	DNM2	2	biochemical	Kim L (1998)	1
ARC	1	FER	1	affinity chromatography technology	Huttlin EL (2017)	1
ERBB3	3	CDC37	0	affinity chromatography technology	Li J (2013)	1
ERBB2	6	CRK	0	unspecified method	Jones RB (2006)	1
CDH1	4	ERBB3	3	bioid	Guo Z (2014)	1
CDH1	4	CRK	0	bioid	Guo Z (2014)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
FER	1	CTTN	1	affinity chromatography technology, biochemical, enzymatic study	Kim L (1998), Kim L (1998), Kim L (1998)	3
NXF1	0	CTNNB1	30	affinity chromatography technology	Castello A (2012)	1
HSP90AA1	7	FER	1	affinity chromatography technology	Taipale M (2012)	1
FER	1	PIK3R3	0	two hybrid	Grossmann A (2015)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
DNM2	2	DNM1	21	two hybrid	Vinayagam A (2011)	1
CDH1	4	LIMA1	4	bioid	Guo Z (2014)	1
FER	1	PPP1R7	4	two hybrid	Grossmann A (2015)	1
ERBB2	6	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, far western blotting	Schroeder JA (2002), Bonvini P (2001), Schroeder JA (2002), Schroeder JA (2002), Kanai Y (1995), Kanai Y (1995)	6
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
NXF1	0	FER	1	affinity chromatography technology	Castello A (2012)	1
ERBB3	3	CRK	0	unspecified method	Jones RB (2006)	1
NXF1	0	ERBB2	6	affinity chromatography technology	Castello A (2012)	1
FER	1	PIK3R1	6	two hybrid	Grossmann A (2015)	1
FER	1	KCTD4	0	two hybrid	Grossmann A (2015)	1
CRK	0	PIK3R3	0	affinity chromatography technology, two hybrid	Brehme M (2009), Grossmann A (2015)	2
EGFR	5	DNM2	2	affinity chromatography technology	Tong J (2014)	1
FER	1	CRK	0	two hybrid	Grossmann A (2015)	1
FER	1	DNM3	3	biochemical	Kim L (1998)	1
LIMA1	4	FER	1	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
CDH1	4	CTTN	1	bioid	Guo Z (2014)	1
FER	1	TMF1	2	two hybrid, enzymatic study	Schwartz Y (1998), Schwartz Y (1998)	2
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
CDC37	0	CTTN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Li J (2013)	3
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
FER	1	ERBB3	3	unspecified method	Jones RB (2006)	1
PIK3R3	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
DNM3	3	DNM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NXF1	0	LIMA1	4	affinity chromatography technology	Castello A (2012)	1
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
FER	1	DNM1	21	biochemical	Kim L (1998)	1
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
ERBB2	6	PIK3R3	0	unspecified method	Jones RB (2006)	1
NXF1	0	CDC37	0	affinity chromatography technology	Castello A (2012)	1
EGFR	5	CTTN	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
DNM3	3	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDH1	4	FER	1	pull down	Piedra J (2003)	1
ERBB3	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hellyer NJ (2001), Lin J (1999), Crovello CS (1998), Graus-Porta D (1997), Jones RB (2006), Li J (2013), Servidei T (2008), Servidei T (2008), Ritch PS (2005), Tang X (2002)	10
CDH1	4	ERBB2	6	bioid	Guo Z (2014)	1
HSP90AA1	7	ERBB3	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Li J (2013)	2
ERBB2	6	FER	1	unspecified method	Jones RB (2006)	1
DNM2	2	PIK3R1	6	affinity chromatography technology	Feng H (2012)	1
CDC37	0	FER	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDH1	4	HSP90AA1	7	affinity chromatography technology	Catimel B (2005)	1
ERBB3	3	PIK3R3	0	unspecified method, affinity chromatography technology	Jones RB (2006), Li J (2013)	2
CDC37	0	ERBB2	6	affinity chromatography technology	Li J (2013)	1
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
EGFR	5	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Schroeder JA (2002), Takahashi K (1997), Li J (2013)	4
FER	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Kim L (1995), Tong J (2008)	2
CTNNB1	30	PIK3R1	6	pull down, imaging technique	Espada J (1999), Chen TC (2014)	2
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
FER	1	CTNNB1	30	enzymatic study	Piedra J (2003)	1
ERBB2	6	PIK3R1	6	affinity chromatography technology, unspecified method	Crovello CS (1998), Jones RB (2006)	2
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
NXF1	0	HSP90AA1	7	affinity chromatography technology	Castello A (2012)	1
FER	1	FER	1	enzymatic study, pull down	Kim L (1998), McDonald NA (2015)	2
EGFR	5	LIMA1	4	affinity chromatography technology	Tong J (2014)	1