PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHEK2	2	KPNA2	0	two hybrid, pull down, affinity chromatography technology	Zannini L (2003), Zannini L (2003), Zannini L (2003)	3
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
PLK1	0	TP53BP1	3	enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	van Vugt MA (2010), van Vugt MA (2010), van Vugt MA (2010), Benada J (2015), Benada J (2015)	5
MUS81	1	WEE1	2	affinity chromatography technology	Dominguez-Kelly R (2011)	1
BRD4	8	ATAD5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rahman S (2011), Rahman S (2011), Rahman S (2011), Rahman S (2011)	4
ENO1	3	TP53BP1	3	affinity chromatography technology	Castello A (2012)	1
PPP2R1A	8	CCAR2	9	affinity chromatography technology	Yadav L (2017)	1
PLK1	0	BRCA2	6	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Lee M (2004), Lin HR (2003), Lin HR (2003), Park I (2017)	4
MSH2	4	ATM	9	biochemical	Wang Y (2000)	1
CHEK2	2	LYPD3	0	two hybrid	Arroyo R (2015)	1
FZR1	1	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDC1	8	RAD50	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Xu X (2003), Goldberg M (2003), Goldberg M (2003), Stewart GS (2003), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008)	7
RB1	2	KAT2B	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nguyen DX (2004), Nguyen DX (2004), Nguyen DX (2004), Ianari A (2009)	4
ATM	9	NR4A1	4	two hybrid	Arroyo R (2015)	1
BRCA1	7	RB1	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, pull down, affinity chromatography technology, genetic interference	Aprelikova ON (1999), Fan S (2001), Fan S (2001), Fan S (2001), Yarden RI (1999), Aprelikova ON (1999), Aprelikova ON (1999), Shen JP (2017)	8
SIRT1	3	WRN	6	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Law IK (2009), Law IK (2009), Li K (2008), Li K (2008), Li K (2008), Li K (2008)	6
PRKDC	12	CHEK2	2	enzymatic study	Chan DW (2000)	1
CHEK2	2	APP	1	pull down	Olah J (2011)	1
CHEK2	2	KLK7	0	two hybrid	Arroyo R (2015)	1
WRN	6	PML	7	affinity chromatography technology	Liu J (2011)	1
PRKDC	12	ATM	9	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Suzuki K (1999), Suzuki K (1999)	3
CHEK2	2	FOXM1	3	enzymatic study	Tan Y (2007)	1
CDC14A	4	CDC6	0	enzymatic study	Bremmer SC (2012)	1
CDK4	2	RFC1	1	affinity chromatography technology	van der Kuip H (1999)	1
SRPK1	2	ERBB2	6	enzymatic study	Varjosalo M (2013)	1
MDM2	2	DAPK3	5	unspecified method, enzymatic study, imaging technique	Burch LR (2004), Burch LR (2004), Felten A (2012)	3
BRCA1	7	RAD50	3	biochemical, biochemical, two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Zhong Q (1999), Zhong Q (1999), Zhong Q (1999), Zhong Q (1999), Greenberg RA (2006), Chen L (2008), Hill SJ (2014), Acharya S (2014)	10
MDM2	2	KAT2B	2	pull down, affinity chromatography technology, genetic interference, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Jin Y (2002), Jin Y (2002), Jin Y (2002), Jin Y (2004), Jin Y (2004), Jung CR (2010), Morgan JE (2017)	7
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
MSH2	4	CHEK2	2	affinity chromatography technology, pull down, affinity chromatography technology	Adamson AW (2005), Brown KD (2003), Brown KD (2003)	3
CUL4A	2	MDM2	2	affinity chromatography technology, affinity chromatography technology	Banks D (2006), Latini P (2011)	2
CHEK2	2	BEX1	0	two hybrid	Arroyo R (2015)	1
ATR	6	WRN	6	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Otterlei M (2006), Patro BS (2011), Patro BS (2011)	4
CHEK2	2	CUL1	7	affinity chromatography technology	Huh J (2013)	1
TUBA1A	13	ATAD5	5	genetic interference	Srivas R (2016)	1
VCP	6	CHEK1	2	affinity chromatography technology	Yu CC (2013)	1
BRCA1	7	BLM	2	biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Acharya S (2014), Ertych N (2016)	3
CHEK2	2	RPS10	0	genetic interference	Srivas R (2016)	1
PML	7	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Alcalay M (1998), Alcalay M (1998), Alcalay M (1998)	3
KAT2B	2	VHL	0	affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Ji W (2014)	2
CDK4	2	CHEK2	2	genetic interference	Shen JP (2017)	1
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
MDM2	2	SIRT1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nihira NT (2017), Nihira NT (2017), Nihira NT (2017)	3
PLK1	0	CDC25C	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Roshak AK (2000), Izumi H (2009), Izumi H (2009), Yun SM (2009)	4
FOXK1	5	TP53BP1	3	affinity chromatography technology	Li X (2015)	1
CUL1	7	RPS10	0	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	CDC14A	4	two hybrid, affinity chromatography technology, pull down	Li L (2000), Li L (2000), Li L (2000)	3
UBR5	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ling S (2011), Ling S (2011), Ling S (2011), Fogeron ML (2013), Flack JE (2017)	5
FZR1	1	CDC25A	2	affinity chromatography technology, pull down, enzymatic study	Gao D (2009), Donzelli M (2002), Donzelli M (2002)	3
VHL	0	CHEK2	2	affinity chromatography technology, enzymatic study	Roe JS (2011), Roe JS (2011)	2
PRKDC	12	WRN	6	unspecified method, affinity chromatography technology, enzymatic study	Kim ST (1999), Karmakar P (2002), Karmakar P (2002)	3
BLM	2	WRN	6	affinity chromatography technology, pull down	von Kobbe C (2002), von Kobbe C (2002)	2
DIRAS3	0	MDM2	2	affinity chromatography technology	Huttlin EL (2015)	1
CHEK2	2	PML	7	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang S (2002), Yang S (2002), Yang S (2002)	3
RAD50	3	RNF8	2	affinity chromatography technology	Lu CS (2012)	1
CDC25C	0	MAPK1	1	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
FOXK1	5	TP53	0	affinity chromatography technology	Li X (2015)	1
TP53	0	RNF20	9	pull down, affinity chromatography technology	Kim J (2005), Kim J (2005)	2
ILKAP	2	CHEK1	2	enzymatic study	Zhang X (2017)	1
CHEK2	2	TP53	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Louria-Hayon I (2003), Shieh SY (2000), Bjorling-Poulsen M (2005), Hirao A (2000), Adams CJ (2008)	5
AATF	0	RB1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Bruno T (2002), Bruno T (2002), Bruno T (2002), Fanciulli M (2000), Fanciulli M (2000), Fanciulli M (2000), Fanciulli M (2000)	7
CDC73	1	PRKDC	12	affinity chromatography technology	Herr P (2015)	1
ELAVL1	0	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Abdelmohsen K (2009), Datta K (2005), Datta K (2005), Yuen JS (2007)	4
CHEK2	2	ERBB2	6	genetic interference	Shen JP (2017)	1
SIRT1	3	PSME3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Liu J (2013), Liu J (2013), Liu J (2013)	3
BRCA1	7	BRD4	8	genetic interference	Shen JP (2017)	1
CHEK2	2	CCL5	1	two hybrid	Arroyo R (2015)	1
ERBB2	6	ILKAP	2	two hybrid	Yao Z (2017)	1
PLK1	0	TP53	0	enzymatic study	Dias SS (2009)	1
CHEK2	2	STMN1	0	two hybrid	Arroyo R (2015)	1
ERBB2	6	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCAR2	9	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hiraike H (2010), Hiraike H (2010), Ertych N (2016)	3
TUBA1A	13	BLM	2	genetic interference	Srivas R (2016)	1
PML	7	FOS	0	pull down	Vallian S (1998)	1
RCHY1	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Corcoran CA (2009), Wang L (2011), Wang L (2011), Corcoran CA (2009)	4
ATM	9	CHEK1	2	unspecified method, enzymatic study, genetic interference	Kim ST (1999), Sorensen CS (2003), Shen JP (2017)	3
VHL	0	APP	1	pull down	Olah J (2011)	1
RNF8	2	MDC1	8	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Huen MS (2007), Mailand N (2007), Mailand N (2007), Kolas NK (2007), Kolas NK (2007), Watanabe S (2013), Henriksson S (2014), Henriksson S (2014), Rassoolzadeh H (2015)	9
BRD4	8	NSD3	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Rahman S (2011), Rahman S (2011), Rahman S (2011), Rahman S (2011), French CA (2014), French CA (2014), Shen C (2015), Shen C (2015), Shen C (2015), Shen C (2015)	10
CDC73	1	CUL1	7	affinity chromatography technology	Herr P (2015)	1
ATM	9	BRCA2	6	pull down	Wang X (2004)	1
CHEK2	2	GNAS	9	two hybrid	Arroyo R (2015)	1
ATM	9	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Bhatia N (2013), Li X (2017), Li X (2017), Li X (2017)	4
KLK9	1	APP	1	pull down	Olah J (2011)	1
PPP2CA	7	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017)	8
PPP2R5C	3	APP	1	pull down	Olah J (2011)	1
PPM1D	11	DIRAS3	0	two hybrid	Arroyo R (2015)	1
VHL	0	SIRT1	3	affinity chromatography technology	Ji W (2014)	1
VHL	0	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Guo J (2016), Guo J (2016)	2
UBR5	13	MAPK3	4	affinity chromatography technology	Eblen ST (2003)	1
FZR1	1	CYP17A1	5	two hybrid	Arroyo R (2015)	1
TUBA1A	13	CHEK2	2	genetic interference	Srivas R (2016)	1
MDC1	8	MDM2	2	unspecified method, affinity chromatography technology	Rodriguez M (2003), Inoue K (2008)	2
CHEK1	2	FZR1	1	genetic interference	Srivas R (2016)	1
CHEK2	2	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
CCAR2	9	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	MDC1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA2	6	KAT2B	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lin HR (2003), Fuks F (1998), Fuks F (1998), Park I (2017)	4
CHEK2	2	WEE1	2	genetic interference	Srivas R (2016)	1
FZR1	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	BLM	2	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sengupta S (2004), Sengupta S (2004), Sengupta S (2004), Wang XW (2001), Wang XW (2001), Wang XW (2001), Wang XW (2001), Garkavtsev IV (2001), Garkavtsev IV (2001), Yang Q (2002), Yang Q (2002), Wang J (2013)	12
CHEK2	2	KAT2B	2	affinity chromatography technology, affinity chromatography technology	Kass EM (2009), Kass EM (2009)	2
FOXM1	3	RNF8	2	affinity chromatography technology, affinity chromatography technology	Kongsema M (2016), Kongsema M (2016)	2
WEE1	2	BLM	2	genetic interference	Srivas R (2016)	1
GINS2	1	CHEK2	2	affinity chromatography technology, affinity chromatography technology	Matsuoka S (2007), Matsuoka S (2007)	2
TP63	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Jung YS (2012), Jung YS (2012), Jung YS (2012)	3
MDM4	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
MAPK1	1	ILKAP	2	biochemical	Wan C (2015)	1
CHEK1	2	ATAD5	5	genetic interference	Srivas R (2016)	1
TP63	0	FOXK2	9	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	RFC1	1	biochemical, affinity chromatography technology	Wang Y (2000), Hill SJ (2014)	2
MDC1	8	PRKDC	12	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Lou Z (2004), Lou Z (2004), Lou Z (2004), Lou Z (2004)	4
TUBA1A	13	WRN	6	genetic interference	Srivas R (2016)	1
CHEK1	2	LATS2	1	enzymatic study, enzymatic study	Okada N (2011), Suzuki H (2013)	2
ELAVL1	0	PRKDC	12	affinity chromatography technology	Abdelmohsen K (2009)	1
PLK3	0	CDC25C	0	enzymatic study, affinity chromatography technology, pull down	Ouyang B (1999), Ouyang B (1999), Ouyang B (1999)	3
WEE1	2	ATAD5	5	genetic interference	Srivas R (2016)	1
CHEK2	2	LATS2	1	enzymatic study	Okada N (2011)	1
CHEK1	2	CDC14A	4	genetic interference	Srivas R (2016)	1
CHEK2	2	DIRAS3	0	two hybrid	Arroyo R (2015)	1
WEE1	2	RB1	2	genetic interference	Srivas R (2016)	1
CDK4	2	CDC6	0	enzymatic study	Anders L (2011)	1
SIRT1	3	RB1	2	affinity chromatography technology	Wang C (2006)	1
CHEK2	2	PRDM14	1	two hybrid	Arroyo R (2015)	1
CHEK2	2	BRCA2	6	affinity chromatography technology, unspecified method	Matsuoka S (2007), Qin D (2003)	2
FOS	0	CHEK2	2	affinity chromatography technology	Li X (2015)	1
PSME3	0	TP53	0	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Zhang Z (2008), Zhang Z (2008), Zhang Z (2008), Liu J (2010), Liu J (2010)	5
SIRT1	3	KPNA2	0	affinity chromatography technology	Law IK (2009)	1
PLK1	0	TUBA1A	13	affinity chromatography technology	Feng Y (1999)	1
BRCA2	6	PPP2CA	7	affinity chromatography technology	Park I (2017)	1
CHEK1	2	TP53	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study	Tian H (2002), Sengupta S (2004), Tian H (2002), Goudelock DM (2003), Shieh SY (2000)	5
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
MDM4	0	MDM2	2	pull down, two hybrid, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Kadakia M (2002), Tanimura S (1999), Badciong JC (2002), Tanimura S (1999), Tanimura S (1999), Linke K (2008), Okamoto K (2005), Pan Y (2003), Kashuba E (2011), Kashuba E (2011), Ohtsubo C (2009), Singh RK (2007), Zhu Y (2009), Zhu Y (2009), Allende-Vega N (2010), Okamoto K (2009), Okamoto K (2009), Li X (2011), Nie J (2010), Nie J (2010), Li M (2011), Li M (2011), Singh RK (2007), de Graaf P (2003), Wade M (2012), Uldrijan S (2007), Wade M (2012), Stad R (2000), Dolezelova P (2012), Kulikov R (2005), Kawai H (2007), Kawai H (2007), Miller KR (2010), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Li C (2002), Wu S (2012), Ranaweera RS (2013), Woodsmith J (2012), Wang J (2011), Egorova O (2014), Chang YS (2013), Malbert-Colas L (2014), Yasuhara T (2014), Yasuhara T (2014), Iyappan S (2010), Stad R (2001), Marcar L (2015), Ling X (2014), Leslie PL (2015), Jacob AG (2014), Jacob AG (2014), Tournillon AS (2015), Tournillon AS (2015), Tournillon AS (2015), Zhang H (2015), Chen L (2015), Pellegrino M (2015), Pellegrino M (2015), Pellegrino M (2015), Medina-Medina I (2016), Medina-Medina I (2016), Moscetti I (2016), Liu T (2017), Liu T (2017), Liu T (2017), Huttlin EL (2017), Wu W (2015), Ivanov AA (2017), Mancini F (2016), Mancini F (2016)	74
CDK4	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PRKDC	12	VHL	0	genetic interference	Shen JP (2017)	1
TP53	0	RPS10	0	two hybrid, affinity chromatography technology	Moon KD (2005), Fogeron ML (2013)	2
CHEK1	2	RAD17	2	genetic interference	Srivas R (2016)	1
BRD4	8	RB1	2	genetic interference	Shen JP (2017)	1
TP63	0	VCP	6	affinity chromatography technology	Amoresano A (2010)	1
CHEK2	2	SLC25A6	3	two hybrid	Arroyo R (2015)	1
FOS	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
PML	7	CUL1	7	affinity chromatography technology	Shima Y (2008)	1
BRCA1	7	ITIH5	1	two hybrid	Woods NT (2012)	1
PML	7	TP63	0	affinity chromatography technology, pull down	Bernassola F (2005), Bernassola F (2005)	2
BRCA1	7	TTN	102	affinity chromatography technology	Ertych N (2016)	1
WEE1	2	CDC73	1	genetic interference	Srivas R (2016)	1
MDM4	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDC25C	0	MAPK3	4	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
CHEK2	2	ST14	2	two hybrid	Arroyo R (2015)	1
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
CHEK2	2	RNF20	9	two hybrid, affinity chromatography technology, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015), Arroyo R (2015)	3
PSME3	0	MDM2	2	affinity chromatography technology, pull down, pull down, pull down	Zhang Z (2008), Zhang Z (2008), Zhang Z (2008), Liu J (2010)	4
CUL1	7	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
CHEK1	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Yarden RI (2002), Yarden RI (2002), Inoue Y (2007), Shen JP (2017)	4
CHEK2	2	RHOBTB2	6	two hybrid	Arroyo R (2015)	1
STMN1	0	TRIM28	1	biochemical	Wan C (2015)	1
CHEK1	2	RFC1	1	genetic interference	Srivas R (2016)	1
VCP	6	PLK1	0	affinity chromatography technology	Yu CC (2013)	1
MDC1	8	ATM	9	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Xu X (2003), Kolas NK (2007), Stewart GS (2003), Stewart GS (2003), Rassoolzadeh H (2015)	5
CHEK1	2	RB1	2	enzymatic study, pull down	Inoue Y (2007), Inoue Y (2007)	2
CHEK2	2	PRMT2	3	two hybrid	Arroyo R (2015)	1
WRN	6	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Partridge JJ (2003), Partridge JJ (2003), Indig FE (2004)	3
BRD4	8	SIRT1	3	affinity chromatography technology	Rahman S (2011)	1
MUS81	1	WRN	6	genetic interference	Vizeacoumar FJ (2013)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
PPM1D	11	RHOBTB2	6	two hybrid	Arroyo R (2015)	1
MSH2	4	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Wang Y (2003), Wang Y (2003), Wang Y (2003), Wang Y (2003), Pabla N (2011), Pabla N (2011), Pabla N (2011)	7
CDC6	0	FZR1	1	pull down, enzymatic study, enzymatic study	Ke PY (2004), Petersen BO (2000), Cotto-Rios XM (2011)	3
ERBB2	6	CYP17A1	5	two hybrid	Arroyo R (2015)	1
PML	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Warren DT (2010), Lim JH (2011), Lim JH (2011)	3
RNF8	2	BLM	2	enzymatic study, pull down	Tikoo S (2013), Tikoo S (2013)	2
CHEK2	2	KLK9	1	two hybrid	Arroyo R (2015)	1
ARHGAP1	0	CHEK2	2	two hybrid	Wang J (2011)	1
TEX264	0	CHEK2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FZR1	1	PLK1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Sedgwick GG (2012), Lee SB (2015), Williamson A (2011)	5
TP53	0	PPP2R5C	3	imaging technique, affinity chromatography technology	Chen TC (2014), Shouse GP (2011)	2
TP53BP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Matsuoka S (2007), Wang B (2002), Bohgaki T (2011), Ertych N (2016)	4
ATM	9	IL24	0	two hybrid, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015)	2
BRCA2	6	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Marmorstein LY (1998)	4
PRKDC	12	BRCA1	7	unspecified method	Kim ST (1999)	1
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
ELAVL1	0	SRPK1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
RB1	2	RFC1	1	affinity chromatography technology	van der Kuip H (1999)	1
ERBB2	6	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
FOS	0	MAPK1	1	affinity chromatography technology	Kumar NV (2001)	1
CHEK2	2	ITIH5	1	two hybrid	Arroyo R (2015)	1
RB1	2	FZR1	1	affinity chromatography technology, biochemical	Binne UK (2007), Binne UK (2007)	2
CHEK2	2	WRN	6	genetic interference	Srivas R (2016)	1
FOXK1	5	FOXK2	9	affinity chromatography technology	Li X (2015)	1
BRCA1	7	KPNA2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Chen CF (1996), Hill SJ (2014), Ertych N (2016)	3
ATR	6	TP53	0	pull down, unspecified method, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, genetic interference	Fabbro M (2004), Kim ST (1999), Lin WC (2001), Wang X (2011), Lakin ND (1999), Rocha S (2005), Dodson GE (2006), Kim ST (1999), Xie L (2013)	9
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
TUBA1A	13	CDC14A	4	genetic interference	Srivas R (2016)	1
PPP2R5A	2	PPP2R5C	3	affinity chromatography technology	Strack S (2002)	1
RPS10	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MDM4	0	APP	1	pull down	Olah J (2011)	1
RNF20	9	CDC73	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Hahn MA (2012), Hahn MA (2012), Herr P (2015)	3
PPP2CA	7	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), McCright B (1996), McCright B (1996), Widau RC (2010), Wan C (2015), Hein MY (2015), Craney A (2016), St-Denis N (2016), Yadav L (2017)	10
BLM	2	VCP	6	genetic interference	Vizeacoumar FJ (2013)	1
PLK1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Zou J (2013), Zou J (2014)	2
WEE1	2	CDC6	0	genetic interference	Srivas R (2016)	1
PPP2CA	7	TP53	0	affinity chromatography technology	Shouse GP (2011)	1
BRCA1	7	MSH2	4	two hybrid, pull down, biochemical, affinity chromatography technology, genetic interference	Wang Q (2001), Wang Q (2001), Wang Y (2000), Wada-Hiraike O (2005), Peng M (2014)	5
SRPK1	2	TP53	0	two hybrid, pull down, affinity chromatography technology	Peidis P (2011), Peidis P (2011), Peidis P (2011)	3
CHEK2	2	ATAD5	5	genetic interference	Srivas R (2016)	1
SRPK2	1	CHEK2	2	enzymatic study	Lipp JJ (2015)	1
CHEK1	2	BLM	2	affinity chromatography technology, imaging technique, genetic interference	Sengupta S (2004), Sengupta S (2004), Srivas R (2016)	3
WEE1	2	BRD4	8	genetic interference	Srivas R (2016)	1
CUL1	7	KPNA2	0	affinity chromatography technology	Bennett EJ (2010)	1
CHEK2	2	MDM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Pereg Y (2006), Kass EM (2009), Kass EM (2009), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005)	7
TP63	0	CHEK2	2	affinity chromatography technology	Huttlin EL (2017)	1
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
SRPK2	1	MDC1	8	enzymatic study	Lipp JJ (2015)	1
MAPK3	4	CHEK2	2	biochemical	Wan C (2015)	1
PPM1D	11	NSD3	6	two hybrid	Arroyo R (2015)	1
CHEK2	2	FZR1	1	genetic interference	Srivas R (2016)	1
PRKDC	12	TP53	0	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Kim ST (1999), Goudelock DM (2003), Yavuzer U (1998), Maiti AK (2010), Shieh SY (1997), Chan DW (2000), Kim ST (1999), Sakaguchi K (1998), Borcherds W (2014)	9
CHEK1	2	CDC6	0	genetic interference	Srivas R (2016)	1
MAPK3	4	ILKAP	2	biochemical	Wan C (2015)	1
MAPK1	1	CHEK1	2	biochemical	Wan C (2015)	1
TP63	0	FOXK1	5	affinity chromatography technology	Huttlin EL (2017)	1
TUBA1A	13	CDC73	1	genetic interference	Srivas R (2016)	1
PML	7	SIAH2	0	affinity chromatography technology, affinity chromatography technology, pull down	Fanelli M (2004), Fanelli M (2004), Fanelli M (2004)	3
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
FZR1	1	VHL	0	affinity chromatography technology, affinity chromatography technology	Liu W (2011), Liu W (2011)	2
VCP	6	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology	Ohama T (2010), Yakovlev VA (2013)	2
CHEK2	2	PPP2R5E	4	two hybrid, pull down	Dozier C (2004), Dozier C (2004)	2
MDM2	2	HMGN1	0	enzymatic study	Guo Z (2013)	1
CUL1	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inuzuka H (2010), Inuzuka H (2010), He Y (2014)	3
CDC73	1	ENO1	3	affinity chromatography technology	Herr P (2015)	1
MUS81	1	PLK1	0	affinity chromatography technology	Matos J (2011)	1
RNF8	2	CHEK2	2	affinity chromatography technology, enzymatic study	Feng L (2012), Feng L (2012)	2
PPM1D	11	KPNA2	0	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Yadav L (2017)	2
ATR	6	BRCA2	6	unspecified method	Kim ST (1999)	1
VHL	0	UBR5	13	affinity chromatography technology	Lai Y (2011)	1
PRKDC	12	RAD17	2	unspecified method	Kim ST (1999)	1
KAT2B	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Jin Y (2002), Wang H (2008), Zhao Y (2006), Roe JS (2006), Perez RE (2010), Tang Y (2006), Zhao LY (2003), Liu L (1999), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Harrod R (2003), MacPartlin M (2005), Chen H (1999), Kang H (2009)	15
MDC1	8	TP53BP1	3	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, imaging technique, affinity chromatography technology	Eliezer Y (2009), Eliezer Y (2009), Eliezer Y (2009), Wood JL (2007), Stewart GS (2003), Stewart GS (2003)	6
VCP	6	CDK4	2	affinity chromatography technology	Yu CC (2013)	1
PPP2R5E	4	APP	1	pull down	Olah J (2011)	1
CHEK2	2	RAD17	2	genetic interference	Srivas R (2016)	1
TEX264	0	FOXK1	5	affinity chromatography technology	Huttlin EL (2015)	1
CHEK2	2	CDC6	0	genetic interference	Srivas R (2016)	1
ATM	9	BRCA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gatei M (2000), Gatei M (2000), Kim ST (1999), Cortez D (1999), Cortez D (1999), Tibbetts RS (2000), Wang Y (2000), Mu JJ (2007), Tsai WB (2008), Gatei M (2000), Gatei M (2000), Gatei M (2000)	12
TP53BP1	3	BLM	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Sengupta S (2004), Sengupta S (2004), Sengupta S (2004)	3
RFC1	1	RAD17	2	biochemical, affinity chromatography technology	Tomida J (2008), Dahm K (2002)	2
TP53	0	PPP2R1A	8	imaging technique, affinity chromatography technology	Chen TC (2014), Kikuchi J (2003)	2
MDC1	8	PPP2CA	7	affinity chromatography technology	Woods NT (2012)	1
MAPK3	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Persons DL (2000), How PC (2011), Lin C (2011), Lin C (2011)	4
CHEK2	2	HOXC6	0	two hybrid	Arroyo R (2015)	1
CHEK2	2	CYP17A1	5	two hybrid	Arroyo R (2015)	1
KPNA2	0	APP	1	pull down	Olah J (2011)	1
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
CDK4	2	PRKDC	12	genetic interference	Shen JP (2017)	1
CHEK2	2	RAD50	3	affinity chromatography technology	Matsuoka S (2007)	1
PPP2CA	7	TRIM28	1	enzymatic study	Mita P (2016)	1
PPP2R2B	1	PPP2CA	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Glatter T (2009), Oberg EA (2012), Oberg EA (2012), Yadav L (2017), Yadav L (2017)	5
MDM2	2	CCAR2	9	affinity chromatography technology	Okoro DR (2013)	1
MDM2	2	RNF8	2	two hybrid	Woodsmith J (2012)	1
BRCA2	6	BRCA1	7	affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sarkisian CJ (2001), Reuter TY (2003), Dong Y (2003), Chen J (1998), Chen J (1998), Villarroel MC (2011), Kumaraswamy E (2007), Sy SM (2009), Sy SM (2009), Sy SM (2009), Johnson N (2013), Hill SJ (2014), Loke J (2015)	13
VHL	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2006), Roe JS (2006), Lai Y (2011), Lai Y (2011)	5
PRKDC	12	CHEK1	2	unspecified method, pull down, genetic interference	Kim ST (1999), Goudelock DM (2003), Shen JP (2017)	3
CHEK2	2	FAM84B	0	two hybrid, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015)	2
CDK4	2	FOXM1	3	enzymatic study	Anders L (2011)	1
CHEK1	2	DAAM1	3	genetic interference	Srivas R (2016)	1
PER3	0	CHEK2	2	affinity chromatography technology	Im JS (2010)	1
CHEK2	2	CHEK2	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study	Ahn JY (2002), Ahn JY (2002), Ahn JY (2002), Xu X (2002), Xu X (2002), Xu X (2002), Zannini L (2003), Sorensen CS (2003), Buscemi G (2001), Oliver AW (2006), Oliver AW (2006), Magni M (2014)	12
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	LATS2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Aylon Y (2006), Aylon Y (2006), Aylon Y (2006)	3
ATM	9	PPP2R5C	3	enzymatic study	Shouse GP (2011)	1
TP53	0	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TUBA1A	13	RB1	2	genetic interference	Srivas R (2016)	1
PRKDC	12	FZR1	1	affinity chromatography technology, affinity chromatography technology	Shang ZF (2015), Shang ZF (2015)	2
VCP	6	STMN1	0	affinity chromatography technology	Yu CC (2013)	1
ELAVL1	0	PPP2R5E	4	affinity chromatography technology	Abdelmohsen K (2009)	1
MSH2	4	CHEK1	2	affinity chromatography technology	Adamson AW (2005)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
ERBB2	6	PRDM14	1	two hybrid	Arroyo R (2015)	1
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
SRPK1	2	CHEK2	2	enzymatic study	Varjosalo M (2013)	1
ELAVL1	0	ATM	9	affinity chromatography technology	Abdelmohsen K (2009)	1
SIRT1	3	FOS	0	pull down, enzymatic study	Zhang R (2010), Zhang R (2010)	2
CDK4	2	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nair JS (2009), Takaki T (2004), Deep G (2006), Kehn K (2004), Scholz A (2003), Gladden AB (2003), Mori S (1999), Higashi H (1996), Musgrove EA (1996), Sarmento LM (2005), Kim KS (2002), Li J (2002), Garcia-Morales P (2006), Tsai CH (2009), Miralem T (2003), Toji S (2004), Halder SK (2005), Dynlacht BD (1997), Mandal M (1998), Voit R (1999), Annicotte JS (2006), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Kitagawa M (1996), Anders L (2011), Gaiddon C (2003), Seo DW (2006), Kabuta T (2013), Lee B (2006), Kossatz U (2006), Zarkowska T (1997), Nakanishi M (1999), Iyer NG (2007), Guidoboni M (2005), Barbash O (2009), Wang C (2001), Denicourt C (2008), Pan W (2001)	39
BRCA1	7	RCHY1	0	affinity chromatography technology	Ertych N (2016)	1
BLM	2	RFC1	1	biochemical	Wang Y (2000)	1
MSH2	4	BLM	2	biochemical, affinity chromatography technology	Wang Y (2000), Yang Q (2004)	2
CUL1	7	FZR1	1	affinity chromatography technology, affinity chromatography technology	Fukushima H (2013), Fukushima H (2013)	2
CUL4A	2	PPP2R1A	8	affinity chromatography technology	Bennett EJ (2010)	1
TP53BP1	3	RNF8	2	imaging technique	Galanty Y (2009)	1
SIRT1	3	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lin Z (2012), Lin YH (2015), Lin YH (2015), Lin YH (2015)	4
BRCA1	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
CHEK1	2	CDC25A	2	pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Goloudina A (2003), Sanchez Y (1997), Sanchez Y (1997), Zhao H (2002), Jin J (2008), Hassepass I (2003), Sorensen CS (2003), Li X (2016)	8
ATM	9	WRN	6	unspecified method	Kim ST (1999)	1
TP63	0	MDM2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zdzalik M (2010), Zdzalik M (2010), Galli F (2010), Calabro V (2002), Calabro V (2002), Stindt MH (2015)	6
FZR1	1	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
CCAR2	9	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Magni M (2014), Magni M (2014), Menssen A (2012), Zannini L (2012), Zannini L (2012)	5
CHEK2	2	PPP2R1A	8	affinity chromatography technology	Dozier C (2004)	1
ATM	9	RNF20	9	biochemical, affinity chromatography technology, enzymatic study	Moyal L (2011), Moyal L (2011), Moyal L (2011)	3
TP53BP1	3	MAPK1	1	affinity chromatography technology	Woods NT (2012)	1
ELAVL1	0	BRD4	8	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
SIAH2	0	CHEK2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study	Garcia-Limones C (2016), Garcia-Limones C (2016), Garcia-Limones C (2016), Garcia-Limones C (2016), Garcia-Limones C (2016), Garcia-Limones C (2016)	6
CHEK2	2	BRD4	8	genetic interference	Srivas R (2016)	1
PRMT2	3	RB1	2	pull down, affinity chromatography technology	Yoshimoto T (2006), Yoshimoto T (2006)	2
CHEK2	2	PPP2R5B	1	pull down	Dozier C (2004)	1
MDC1	8	WRN	6	unspecified method	Rodriguez M (2003)	1
MUS81	1	RFC1	1	genetic interference	Vizeacoumar FJ (2013)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
BRD4	8	CUL1	7	affinity chromatography technology	Dai X (2017)	1
PSME3	0	CCAR2	9	affinity chromatography technology, affinity chromatography technology	Magni M (2014), Magni M (2014)	2
BRCA1	7	CDK4	2	pull down, enzymatic study, enzymatic study	Wang H (1997), Kehn K (2007), Miralem T (2003)	3
ELAVL1	0	LLGL1	9	affinity chromatography technology	Abdelmohsen K (2009)	1
CHEK2	2	CDH13	5	two hybrid	Arroyo R (2015)	1
TUBA1A	13	WEE1	2	genetic interference	Srivas R (2016)	1
TUBA1A	13	LLGL1	9	genetic interference	Srivas R (2016)	1
CHEK2	2	PPM1D	11	pull down, pull down, enzymatic study, affinity chromatography technology	Fujimoto H (2006), Fujimoto H (2006), Fujimoto H (2006), Fujimoto H (2006)	4
TP53BP1	3	CHEK1	2	imaging technique	Sengupta S (2004)	1
PER3	0	ATM	9	affinity chromatography technology	Im JS (2010)	1
NR4A1	4	TP53	0	affinity chromatography technology, pull down, pull down	Zhao BX (2006), Zhao BX (2006), Zhao BX (2006)	3
BRCA1	7	STRAP	2	affinity chromatography technology	Ertych N (2016)	1
VCP	6	UBR5	13	affinity chromatography technology	Yu CC (2013)	1
ATM	9	VHL	0	affinity chromatography technology, genetic interference	Roe JS (2006), Shen JP (2017)	2
CUL1	7	CHEK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu S (2009), Huh J (2013), Zhang YW (2005)	3
PPP2R2B	1	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, bioid	Glatter T (2009), Oberg EA (2012), Wan C (2015), Hein MY (2015), Yadav L (2017), Yadav L (2017)	6
CHEK1	2	TTN	102	genetic interference	Srivas R (2016)	1
CHEK2	2	PPP2R5D	29	two hybrid, pull down	Dozier C (2004), Dozier C (2004)	2
AATF	0	DAPK3	5	imaging technique	Felten A (2012)	1
PLK1	0	CHEK2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Tsvetkov L (2003), Tsvetkov L (2003), Tsvetkov L (2003), van Vugt MA (2010)	4
ATM	9	TP53BP1	3	pull down, enzymatic study, enzymatic study	Fernandez-Capetillo O (2002), Ward IM (2003), Lee H (2009)	3
MDM4	0	TP53	0	enzymatic study, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, protein complementation assay, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, fluorescent resonance energy transfe, pull down	Badciong JC (2002), Shvarts A (1997), Shvarts A (1997), Tang Y (2008), Okamoto K (2005), Chen L (2005), Wang X (2001), Ohtsubo C (2009), Zdzalik M (2010), Singh RK (2007), Kim S (2010), Li M (2011), Li M (2011), David Y (2011), de Graaf P (2003), Wade M (2012), Wade M (2012), Wade M (2012), Stad R (2000), Stad R (2000), Bernal F (2010), Bernal F (2010), Bernal F (2010), Bernal F (2010), Miller KR (2010), Zuckerman V (2009), Kallen J (2009), Czarna A (2009), Czarna A (2009), Popowicz GM (2008), Hu B (2007), Sharp DA (1999), Li C (2002), Di Conza G (2012), Mancini F (2009), Mancini F (2009), Wu S (2012), Shan B (2012), Wu S (2012), Wu S (2012), Ranaweera RS (2013), Bista M (2013), Bista M (2013), Wang CL (2014), Wang CL (2014), Rallapalli R (1999), Chang YS (2013), Chang YS (2013), Tan BX (2014), Huttlin EL (2015), Sanchez MC (2010), Sanchez MC (2010), Li YC (2014), Li X (2015), Chen X (2015), Chen L (2015), Chen L (2015), Chen L (2015), Wei X (2016), Wei X (2016), Xie X (2016), Huttlin EL (2017), Borcherds W (2017), Shangary S (2008), Ivanov AA (2017), Mancini F (2016)	66
PPP2R1A	8	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Dozier C (2004), Fogeron ML (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Shouse GP (2011), Yadav L (2017), Yadav L (2017)	10
CUL1	7	PPP2CA	7	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	TP53BP1	3	x-ray crystallography, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method	Derbyshire DJ (2002), Sengupta S (2004), Sengupta S (2004), Ekblad CM (2004), Lo KW (2005), Joo WS (2002), Derbyshire DJ (2002), Iwabuchi K (1994), Iwabuchi K (1994), Iwabuchi K (1994), Roy S (2010), Dai C (2011), Tembe V (2015), Cuella-Martin R (2016), Cuella-Martin R (2016), Tong Q (2015), Tong Q (2015)	17
BRCA1	7	PSME3	0	affinity chromatography technology	Ertych N (2016)	1
CHEK2	2	PPP2R5C	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Dozier C (2004), Dozier C (2004), Dozier C (2004), Dozier C (2004), Dozier C (2004), Dozier C (2004)	6
PPP2CA	7	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito A (2000), Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Dozier C (2004), Letourneux C (2006), Wan C (2015), St-Denis N (2016), Shouse GP (2011), Shouse GP (2011), Yadav L (2017)	12
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
CHEK2	2	ENO1	3	two hybrid	Arroyo R (2015)	1
PPP2R2B	1	TRIM28	1	affinity chromatography technology	Glatter T (2009)	1
CHEK2	2	POLR2L	1	two hybrid	Wang J (2011)	1
MDC1	8	TP53	0	affinity chromatography technology	Xu X (2003)	1
ATR	6	RAD17	2	unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kim ST (1999), Bao S (2001), Bao S (2001), Bomgarden RD (2004), Zhang L (2010)	5
VCP	6	MAPK1	1	affinity chromatography technology	Yu CC (2013)	1
AATF	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Nicola F (2007), De Nicola F (2007), De Nicola F (2014)	3
FZR1	1	FOXM1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park HJ (2008), Myatt SS (2013), Laoukili J (2008), Laoukili J (2008)	4
BRCA1	7	CDC25C	0	enzymatic study	Shabbeer S (2013)	1
PML	7	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bernardi R (2004), Bernardi R (2004), Zhu H (2003), Zhu H (2003), Kurki S (2003), Kurki S (2003), Wei X (2003), Wei X (2003), Wu Q (2009), Chu Y (2011), Yang Q (2013), Yang Q (2013), Bursac S (2012)	13
FZR1	1	CCL5	1	two hybrid	Arroyo R (2015)	1
CHEK2	2	CDC25C	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Eymin B (2006), Xu X (2002), Yang S (2002), Zannini L (2003), Buscemi G (2001), Zhou BB (2000), Magni M (2014), Wu X (2001), Fujimoto H (2006)	9
CDC73	1	RPS10	0	affinity chromatography technology	Herr P (2015)	1
MDM4	0	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Uchida C (2006), Uchida C (2006), Zhang H (2015), Zhang H (2015)	4
VCP	6	TP53BP1	3	affinity chromatography technology	Yu CC (2013)	1
NR4A1	4	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down	Kim BY (2008), Kim BY (2008), Kim BY (2008)	3
PRKDC	12	PPP2CA	7	affinity chromatography technology	Douglas P (2010)	1
CHEK2	2	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Lee JS (2000), Lee JS (2000), Chabalier-Taste C (2008), Chabalier-Taste C (2008), Liu Y (2002), Inoue Y (2007), Dutta D (2015), Dutta D (2015)	8
MDM2	2	RAD50	3	affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005)	2
CDC25A	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2003), Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016)	6
CHEK1	2	WRN	6	genetic interference	Srivas R (2016)	1
RB1	2	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Hsieh JK (1999), Nguyen DX (2004), Zheng Z (2012), Sdek P (2005), Delston RB (2011), Delston RB (2011), Sdek P (2004), Sdek P (2004), Xiao ZX (1995), Xiao ZX (1995), Xiao ZX (1995), Uchida C (2006), Markham D (2006), Chan HM (2001), Chan HM (2001), Zhang H (2015), Zhang H (2015), Jaenicke RU (1996)	18
TUBA1A	13	CHEK1	2	genetic interference	Srivas R (2016)	1
CUL1	7	SLC25A6	3	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	CHEK2	2	affinity chromatography technology	Matsuoka S (2007)	1
VHL	0	TRIM28	1	pull down	Li Z (2003)	1
FOXK2	9	RB1	2	affinity chromatography technology	Li X (2015)	1
CHEK2	2	BAALC	0	two hybrid	Arroyo R (2015)	1
RB1	2	FOXM1	3	affinity chromatography technology	Major ML (2004)	1
PPM1D	11	MDM2	2	affinity chromatography technology, affinity chromatography technology	Lu X (2007), Lu X (2007)	2
MDC1	8	FZR1	1	affinity chromatography technology	Woods NT (2012)	1
RFC1	1	TP53	0	affinity chromatography technology	Anderson LA (2003)	1
WEE1	2	TTN	102	genetic interference	Srivas R (2016)	1
CDC73	1	VCP	6	affinity chromatography technology	Herr P (2015)	1
FOXK2	9	SRPK2	1	affinity chromatography technology	Li X (2015)	1
MDC1	8	CHEK2	2	affinity chromatography technology, pull down	Lou Z (2003), Lou Z (2003)	2
HOXC6	0	APP	1	pull down	Olah J (2011)	1
CHEK2	2	TP53BP1	3	affinity chromatography technology	Matsuoka S (2007)	1
CDK4	2	APP	1	pull down	Olah J (2011)	1
MAPK1	1	UBR5	13	enzymatic study, affinity chromatography technology	Eblen ST (2003), Eblen ST (2003)	2
MSH2	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zink D (2002), Zink D (2002), Yang Q (2004)	3
FOXK1	5	CHEK2	2	affinity chromatography technology	Li X (2015)	1
CHEK2	2	REV3L	8	enzymatic study	Brondello JM (2008)	1
VCP	6	MAPK3	4	affinity chromatography technology	Yu CC (2013)	1
CHEK2	2	PSME3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zannini L (2009), Zannini L (2009), Magni M (2014)	3
CDK4	2	ERBB2	6	genetic interference, fluorescent resonance energy transfe	Shen JP (2017), Ivanov AA (2017)	2
SIAH2	0	LATS2	1	affinity chromatography technology, affinity chromatography technology	Ma B (2016), Ma B (2016)	2
ERBB2	6	RHOBTB2	6	two hybrid	Arroyo R (2015)	1
PPM1D	11	ITIH5	1	two hybrid	Arroyo R (2015)	1
ATM	9	NSD3	6	two hybrid, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015)	2
PML	7	MAPK3	4	affinity chromatography technology	Warren DT (2010)	1
CHEK1	2	VHL	0	genetic interference	Shen JP (2017)	1
CDC6	0	ATM	9	pull down	Yoshida K (2010)	1
MUS81	1	VCP	6	genetic interference	Vizeacoumar FJ (2013)	1
CHEK2	2	KMT2D	30	genetic interference	Shen JP (2017)	1
PPP2R5A	2	PPP2R5D	29	biochemical	Wan C (2015)	1
SRPK2	1	APP	1	pull down	Olah J (2011)	1
KLK7	0	APP	1	pull down	Olah J (2011)	1
CHEK2	2	LLGL1	9	genetic interference	Srivas R (2016)	1
CHEK2	2	PPP2R2B	1	two hybrid	Dozier C (2004)	1
CHEK1	2	WEE1	2	genetic interference, genetic interference	Srivas R (2016), Srivas R (2016)	2
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
CHEK1	2	CDC73	1	genetic interference	Srivas R (2016)	1
DAPK3	5	TP53	0	enzymatic study	Burch LR (2004)	1
MDC1	8	ENO1	3	affinity chromatography technology	Woods NT (2012)	1
PLK1	0	MDM2	2	enzymatic study, affinity chromatography technology, pull down	Dias SS (2009), Dias SS (2009), Dias SS (2009)	3
PML	7	PSME3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zannini L (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TP63	0	MDM4	0	pull down, pull down	Zdzalik M (2010), Zdzalik M (2010)	2
MAPK1	1	CHEK2	2	biochemical	Wan C (2015)	1
FZR1	1	TP53	0	enzymatic study	Gmachl M (2000)	1
ELAVL1	0	SIRT1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
DAPK3	5	CHEK2	2	enzymatic study	Burch LR (2004)	1
TRIM28	1	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Gilmore-Hebert M (2010), Okamoto K (2006)	3
CHEK2	2	STRAP	2	enzymatic study	Adams CJ (2008)	1
PML	7	SIRT1	3	affinity chromatography technology, pull down	Langley E (2002), Langley E (2002)	2
CHEK2	2	DAAM1	3	genetic interference	Srivas R (2016)	1
BRCA1	7	MAPK3	4	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
WEE1	2	FZR1	1	genetic interference	Srivas R (2016)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
MAPK1	1	PPP2R5B	1	enzymatic study	Letourneux C (2006)	1
BRCA1	7	ENO1	3	two hybrid, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
PRMT2	3	UBR5	13	affinity chromatography technology	Huttlin EL (2017)	1
LYPD3	0	ATR	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53BP1	3	MAPK3	4	affinity chromatography technology	Woods NT (2012)	1
CUL1	7	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
VHL	0	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Lai Y (2011), Hergovich A (2003)	2
MDM4	0	RAD50	3	affinity chromatography technology	Carrillo AM (2015)	1
CHEK2	2	CDC14A	4	genetic interference	Srivas R (2016)	1
ATM	9	MDM2	2	enzymatic study, enzymatic study	Wang Z (2012), Luo H (2016)	2
CHEK2	2	CUL4A	2	affinity chromatography technology	Huh J (2013)	1
CUL4A	2	SLC25A6	3	affinity chromatography technology	Bennett EJ (2010)	1
FOXK2	9	KMT2D	30	affinity chromatography technology	Li X (2015)	1
CHEK1	2	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leung-Pineda V (2009), Liu S (2009), Huh J (2013), Zhang YW (2005)	4
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
TP53	0	TUBA1A	13	affinity chromatography technology	Fogeron ML (2013)	1
CHEK2	2	UBR5	13	affinity chromatography technology, affinity chromatography technology	Henderson MJ (2006), Henderson MJ (2006)	2
SRPK1	2	APP	1	pull down	Olah J (2011)	1
PML	7	NR4A1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wu WS (2002), Wu WS (2002), Wu WS (2002), Wu WS (2002)	4
SRPK2	1	TTN	102	enzymatic study	Varjosalo M (2013)	1
SIRT1	3	KAT2B	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Pediconi N (2009), Pediconi N (2009), Pediconi N (2009)	3
RAD50	3	BLM	2	biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Acharya S (2014), Acharya S (2014)	3
WEE1	2	WRN	6	genetic interference	Srivas R (2016)	1
FOXK2	9	TP53BP1	3	affinity chromatography technology	Li X (2015)	1
CHEK2	2	IL24	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015), Arroyo R (2015)	3
BRD4	8	RFC1	1	affinity chromatography technology, affinity chromatography technology, pull down	Maruyama T (2002), Maruyama T (2002), Maruyama T (2002)	3
CHEK2	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Magni M (2014), Magni M (2014)	2
CHEK2	2	CDC25A	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Jin J (2008), Hassepass I (2003), Sorensen CS (2003), Falck J (2001), Falck J (2001)	5
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
ATR	6	CHEK1	2	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, genetic interference	Kim ST (1999), Sun TP (2009), Zhao H (2001), Rocha S (2005), Choi JH (2007), Ha K (2011), Srivas R (2016)	7
PPP2R1A	8	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	9
MAPK1	1	TTN	102	enzymatic study, genetic interference	Raskin A (2012), Srivas R (2016)	2
TP53	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PLK1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CHEK1	2	LLGL1	9	genetic interference	Srivas R (2016)	1
ATM	9	RFC1	1	biochemical	Wang Y (2000)	1
SIAH2	0	KAT2B	2	affinity chromatography technology	Grishina I (2012)	1
PLK1	0	WEE1	2	enzymatic study	Watanabe N (2004)	1
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
CHEK1	2	BRD4	8	genetic interference	Srivas R (2016)	1
PPP2R1A	8	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Havugimana PC (2012), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	11
CDC14A	4	FZR1	1	enzymatic study	Bembenek J (2001)	1
CHEK2	2	MDM4	0	enzymatic study	Chen L (2005)	1
CHEK2	2	CCAR2	9	affinity chromatography technology, affinity chromatography technology	Magni M (2014), Magni M (2014)	2
LATS2	1	PPP2R1A	8	affinity chromatography technology	Couzens AL (2013)	1
TP53BP1	3	STRAP	2	affinity chromatography technology	Woods NT (2012)	1
PLK3	0	TP53	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xie S (2001), Xie S (2001), Bahassi el M (2002), Bahassi el M (2002)	4
ATM	9	TP53	0	pull down, pull down, pull down, genetic interference, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Kang J (2005), Fabbro M (2004), Khanna KK (1998), Westphal CH (1997), Kim ST (1999), Khanna KK (1998), Lee JH (2004), Lee JH (2004), Hunt CR (2007), Lin WC (2001), Ling S (2011), Taira N (2010), Lee JH (2005), Zhou BB (2000), Chan DW (2000), Yoshiyama KO (2013), Kim ST (1999), Zhang P (2014), Wang L (2014), Golding SE (2004), Ochodnicka-Mackovicova K (2016)	21
CHEK2	2	BLM	2	genetic interference	Srivas R (2016)	1
CHEK2	2	RFC1	1	genetic interference	Srivas R (2016)	1
NR4A1	4	KAT2B	2	pull down	Wansa KD (2002)	1
WRN	6	TP53	0	affinity chromatography technology, pull down, pull down	Yang Q (2002), Yang Q (2002), Brosh RM (2001)	3
MAPK3	4	PPP2CA	7	affinity chromatography technology	Quevedo C (2003)	1
CHEK1	2	CDC25C	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sanchez Y (1997), Sanchez Y (1997), Olson E (2006), Eymin B (2006), Maude SL (2005), Yarden RI (2002), Chen J (2000), Sun TP (2009), Zhao H (2001), Groth A (2003), Graves PR (2000), Arlander SJ (2006)	12
AATF	0	CHEK2	2	pull down, affinity chromatography technology	Bruno T (2006), Bruno T (2006)	2
CHEK2	2	RCHY1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bohgaki M (2013), Bohgaki M (2013), Bohgaki M (2013)	3
PPP2R5C	3	MDM2	2	affinity chromatography technology	Shouse GP (2011)	1
CHEK1	2	MDM4	0	enzymatic study, enzymatic study	Jin Y (2006), Chen L (2005)	2
PPP2CA	7	PPP2R5B	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), McCright B (1996), McCright B (1996), Shamay M (2012), Letourneux C (2006), Letourneux C (2006), St-Denis N (2016), Yadav L (2017)	8
CHEK2	2	CDC73	1	genetic interference	Srivas R (2016)	1
CHEK2	2	RB1	2	enzymatic study, pull down, affinity chromatography technology	Inoue Y (2007), Inoue Y (2007), Inoue Y (2007)	3
MDM2	2	GNAS	9	affinity chromatography technology	Tang T (2008)	1
TP53	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CUL4A	2	ENO1	3	affinity chromatography technology	Bennett EJ (2010)	1
MUS81	1	POLR2L	1	genetic interference	Vizeacoumar FJ (2013)	1
RAD50	3	ATM	9	biochemical	Wang Y (2000)	1
PPP2CA	7	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	10
MAPK1	1	PPP2R5C	3	enzymatic study	Letourneux C (2006)	1
RCHY1	0	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Leng RP (2003), Leng RP (2003), Sheng Y (2008), Sheng Y (2008), Corcoran CA (2009), Duan S (2007), Duan S (2007), Duan S (2007), Duan S (2007), Shloush J (2011), Jung YS (2011), Wu G (2010), Wu G (2010), Wang J (2011), Abou Zeinab R (2013), Corcoran CA (2009), Corcoran CA (2009), Yan W (2014), Yan W (2014), Yan W (2014)	20
VCP	6	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Ohama T (2010), Yakovlev VA (2013)	2
FOXK2	9	TP53	0	affinity chromatography technology	Li X (2015)	1
TP53BP1	3	TRIM28	1	affinity chromatography technology	Lin YH (2015)	1
BRCA1	7	PPP2R5C	3	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
CDC14A	4	PLK1	0	affinity chromatography technology, enzymatic study	van Leuken R (2009), van Leuken R (2009)	2
CHEK2	2	PPP2R5A	2	two hybrid, pull down	Dozier C (2004), Dozier C (2004)	2
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
ERBB2	6	LYPD3	0	two hybrid	Arroyo R (2015)	1
CDC6	0	ATR	6	pull down, affinity chromatography technology	Yoshida K (2010), Yoshida K (2010)	2
BRCA1	7	WEE1	2	genetic interference	Shen JP (2017)	1
CHEK2	2	TTN	102	genetic interference	Srivas R (2016)	1
ELAVL1	0	CHEK2	2	affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Abdelmohsen K (2009), Abdelmohsen K (2007), Abdelmohsen K (2007), Abdelmohsen K (2007)	4
RAD50	3	MSH2	4	biochemical	Wang Y (2000)	1
VCP	6	MDM2	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Okoro DR (2013)	2
ELAVL1	0	PPP2R1A	8	affinity chromatography technology	Abdelmohsen K (2009)	1
MUS81	1	CHEK2	2	affinity chromatography technology, pull down	Chen XB (2001), Chen XB (2001)	2
CDK4	2	VHL	0	genetic interference	Shen JP (2017)	1
VCP	6	RNF8	2	two hybrid	Rolland T (2014)	1
FZR1	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPP2R1A	8	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Widau RC (2010), Wan C (2015), Hein MY (2015), Yadav L (2017), Yadav L (2017)	9
BRCA1	7	PPP2CA	7	affinity chromatography technology	Woods NT (2012)	1
ATM	9	CHEK2	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Lee JH (2004), Lee JH (2004), Matsuoka S (2000), Lee JH (2005), Zhou BB (2000), Chan DW (2000)	6
CDC14A	4	DAPK3	5	bioid	St-Denis N (2016)	1
CUL1	7	ENO1	3	affinity chromatography technology	Bennett EJ (2010)	1
MSH2	4	RFC1	1	biochemical	Wang Y (2000)	1
CHEK2	2	TRIM28	1	affinity chromatography technology	Hu C (2012)	1
NR4A1	4	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down	Rambaud J (2009), Rambaud J (2009), Rambaud J (2009)	3
CHEK2	2	TLR3	2	two hybrid	Arroyo R (2015)	1
CHEK2	2	PPP2CA	7	affinity chromatography technology, enzymatic study	Dozier C (2004), Liang X (2006)	2
ELAVL1	0	FAM84B	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PPP2R1A	8	CDK4	2	affinity chromatography technology	Sablina AA (2007)	1
ATM	9	RAD17	2	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Bao S (2001), Tsai WB (2008)	3
CHEK2	2	NR4A1	4	two hybrid	Wang J (2011)	1
ATR	6	CHEK2	2	enzymatic study, enzymatic study, genetic interference	Olson E (2006), Matsuoka S (2000), Srivas R (2016)	3
CDC25A	2	APP	1	pull down	Olah J (2011)	1
CHEK1	2	APP	1	pull down	Olah J (2011)	1
PPP2R5E	4	PPP2R5C	3	biochemical	Wan C (2015)	1
TUBA1A	13	TTN	102	genetic interference	Srivas R (2016)	1
ATM	9	BLM	2	biochemical, pull down, affinity chromatography technology	Wang Y (2000), Beamish H (2002), Beamish H (2002)	3
PPM1D	11	LYPD3	0	two hybrid	Arroyo R (2015)	1
PPP2CA	7	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Kong M (2009), Kong M (2009), Shamay M (2012), Havugimana PC (2012), Junttila MR (2007), Junttila MR (2007), Nazarenko I (2007), Kristensen AR (2012), Fogeron ML (2013), Sablina AA (2010), Lee CW (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Cianfanelli V (2015), St-Denis N (2016), Bryant JC (1999), Shouse GP (2011), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	30
CHEK2	2	NSD3	6	two hybrid	Arroyo R (2015)	1
SRPK1	2	KPNA2	0	enzymatic study	Varjosalo M (2013)	1
ATR	6	BRCA1	7	pull down, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Tibbetts RS (2000), Kim ST (1999), Mu JJ (2007), Chen J (2000), Chen J (2000), Tibbetts RS (2000), Gatei M (2001), Gatei M (2001), Gatei M (2001), Tian F (2013)	10
PLK3	0	CHEK2	2	enzymatic study, affinity chromatography technology	Bahassi el M (2002), Bahassi el M (2002)	2
FOXK1	5	RB1	2	affinity chromatography technology	Li X (2015)	1
CDC25A	2	VCP	6	affinity chromatography technology	Riemer A (2014)	1
FZR1	1	BEX1	0	two hybrid	Arroyo R (2015)	1
ILKAP	2	CHEK2	2	biochemical	Wan C (2015)	1
MDC1	8	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Matsuoka S (2007), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Lou Z (2003), Mok MT (2010), Au WW (2005)	7
ELAVL1	0	LATS2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
FOXK2	9	CHEK2	2	affinity chromatography technology	Li X (2015)	1
KAT2B	2	TP63	0	enzymatic study, enzymatic study	MacPartlin M (2005), Chae YS (2012)	2
BLM	2	ATR	6	affinity chromatography technology, affinity chromatography technology, enzymatic study	Davies SL (2004), Davies SL (2004), Davies SL (2004)	3
FOS	0	RB1	2	pull down	Nead MA (1998)	1
BRCA1	7	TP63	0	affinity chromatography technology, imaging technique	Buckley NE (2011), Buckley NE (2014)	2
CHEK2	2	HMGN1	0	two hybrid	Arroyo R (2015)	1
CHEK1	2	RPS10	0	genetic interference	Srivas R (2016)	1
RAD50	3	RFC1	1	biochemical	Wang Y (2000)	1